KEGG   PATHWAY: vbh02010Help
vbh02010                    Pathway                                

ABC transporters - Nibricoccus aquaticus HZ-65
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Environmental Information Processing; Membrane transport
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vbh02010  ABC transporters

Ortholog table
Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Nibricoccus aquaticus HZ-65 [GN:vbh]
CMV30_15170  hypothetical protein [KO:K02048]
CMV30_15160  sulfate transporter subunit [KO:K23163]
CMV30_15180  cysT; sulfate ABC transporter permease subunit CysT [KO:K02046]
CMV30_15185  cysW; sulfate ABC transporter permease subunit CysW [KO:K02047]
CMV30_15190  sulfate ABC transporter ATP-binding protein [KO:K02045] [EC:]
CMV30_00370  nitrate ABC transporter substrate-binding protein [KO:K15576]
CMV30_00380  nitrate ABC transporter substrate-binding protein [KO:K15576]
CMV30_00375  ntrB; nitrate ABC transporter, permease protein [KO:K15577]
CMV30_00385  nitrate ABC transporter ATP-binding protein [KO:K15578] [EC:3.6.3.-]
CMV30_14040  modA; molybdate ABC transporter substrate-binding protein [KO:K02020]
CMV30_14035  modB; molybdate ABC transporter permease subunit [KO:K02018]
CMV30_14030  molybdenum ABC transporter ATP-binding protein [KO:K02017] [EC:]
CMV30_01640  ABC transporter permease [KO:K02011]
CMV30_17165  hypothetical protein [KO:K10112]
CMV30_15505  sugar ABC transporter ATP-binding protein [KO:K10112]
CMV30_08525  ABC transporter permease [KO:K10202]
CMV30_03590  ABC transporter permease [KO:K17246]
CMV30_06550  hypothetical protein [KO:K02067]
CMV30_06540  hypothetical protein [KO:K02066]
CMV30_11655  hypothetical protein [KO:K02066]
CMV30_06545  ABC transporter ATP-binding protein [KO:K02065]
CMV30_11660  polyamine ABC transporter ATP-binding protein [KO:K02065]
CMV30_10925  sugar ABC transporter substrate-binding protein [KO:K10439]
CMV30_08380  rbsC; ribose ABC transporter permease [KO:K10440]
CMV30_10915  ABC transporter permease [KO:K10440]
CMV30_08385  D-xylose ABC transporter ATP-binding protein [KO:K10441] [EC:]
CMV30_10920  sugar ABC transporter [KO:K10441] [EC:]
CMV30_11070  transport protein RbsD/FucU [KO:K06726] [EC:]
CMV30_10665  sugar ABC transporter substrate-binding protein [KO:K10537]
CMV30_10650  araH; L-arabinose ABC transporter permease AraH [KO:K10538]
CMV30_10655  araG; L-arabinose ABC transporter ATP-binding protein AraG [KO:K10539] [EC:]
CMV30_02070  LacI family transcriptional regulator [KO:K23508]
CMV30_02060  sugar ABC transporter permease [KO:K23509]
CMV30_02055  sugar ABC transporter permease YjfF [KO:K23509]
CMV30_02065  sugar ABC transporter ATP-binding protein [KO:K10820] [EC:]
CMV30_07330  xylF; D-xylose transporter subunit XylF [KO:K10543]
CMV30_07320  ATPase [KO:K10544]
CMV30_04605  ABC transporter permease [KO:K10560]
CMV30_04600  D-xylose ABC transporter ATP-binding protein [KO:K10562] [EC:7.5.2.-]
CMV30_03210  hypothetical protein [KO:K02040]
CMV30_12130  phosphate-binding protein [KO:K02040]
CMV30_12135  pstC; phosphate ABC transporter permease subunit PstC [KO:K02037]
CMV30_12140  pstA; phosphate ABC transporter, permease protein PstA [KO:K02038]
CMV30_12145  phosphate ABC transporter ATP-binding protein [KO:K02036] [EC:]
CMV30_14565  urtA; urea ABC transporter substrate-binding protein [KO:K11959]
CMV30_14570  urtB; urea ABC transporter permease subunit UrtB [KO:K11960]
CMV30_14575  urtC; urea ABC transporter permease subunit UrtC [KO:K11961]
CMV30_14580  urtD; urea ABC transporter ATP-binding protein UrtD [KO:K11962]
CMV30_14585  ABC transporter ATP-binding protein [KO:K11963]
CMV30_00980  ABC transporter substrate-binding protein [KO:K15580]
CMV30_02300  peptide ABC transporter substrate-binding protein [KO:K15580]
CMV30_04420  ABC transporter substrate-binding protein [KO:K15580]
CMV30_13625  peptide ABC transporter substrate-binding protein [KO:K15580]
CMV30_02305  ABC transporter [KO:K15581]
CMV30_02310  peptide ABC transporter permease [KO:K15582]
CMV30_15770  dipeptide/oligopeptide/nickel ABC transporter ATP-binding protein [KO:K15583]
CMV30_15765  peptide ABC transporter substrate-binding protein [KO:K10823]
CMV30_02420  ABC transporter substrate-binding protein [KO:K11707]
CMV30_02405  ABC transporter [KO:K11708]
CMV30_02400  ABC transporter [KO:K11709]
CMV30_02410  manganese ABC transporter ATP-binding protein [KO:K11710] [EC:]
CMV30_14465  manganese ABC transporter ATP-binding protein [KO:K11710] [EC:]
CMV30_04530  ABC transporter permease [KO:K09690]
CMV30_12685  sugar ABC transporter permease [KO:K09690]
CMV30_18120  phosphate ABC transporter permease [KO:K09690]
CMV30_04535  ABC transporter ATP-binding protein [KO:K09691]
CMV30_12680  ABC transporter ATP-binding protein [KO:K09691]
CMV30_18115  ABC transporter ATP-binding protein [KO:K09691]
CMV30_05685  hypothetical protein [KO:K09696]
CMV30_05680  ABC transporter ATP-binding protein [KO:K09697] [EC:]
CMV30_02275  ABC transporter permease [KO:K09808]
CMV30_15355  ABC transporter permease [KO:K09808]
CMV30_02270  ABC transporter ATP-binding protein [KO:K09810] [EC:3.6.3.-]
CMV30_09470  ABC transporter [KO:K09810] [EC:3.6.3.-]
CMV30_00350  permease [KO:K07091]
CMV30_04105  permease [KO:K11720]
CMV30_01575  lptB; LPS export ABC transporter ATP-binding protein [KO:K06861] [EC:3.6.3.-]
CMV30_03790  hypothetical protein [KO:K19341]
CMV30_02315  ABC transporter [KO:K11085] [EC:3.6.3.-]
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00753  Tungsten
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  D-Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Tomii K, Kanehisa M.
A comparative analysis of ABC transporters in complete microbial genomes.
Genome Res 8:1048-59 (1998)
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
J Bacteriol 190:4460-9 (2008)
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Proc Natl Acad Sci U S A 105:5537-42 (2008)
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Proc Natl Acad Sci U S A 96:13571-6 (1999)
Quintero MJ, Montesinos ML, Herrero A, Flores E
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Genome Res 11:2034-40 (2001)
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Mol Microbiol 57:1582-92 (2005)
Valladares A, Montesinos ML, Herrero A, Flores E.
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Mol Microbiol 43:703-15 (2002)
Richard-Fogal CL, Frawley ER, Kranz RG
Topology and function of CcmD in cytochrome c maturation.
J Bacteriol 190:3489-93 (2008)
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
J Bacteriol 187:5861-7 (2005)
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
J Bacteriol 189:8361-5 (2007)
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Mol Microbiol 63:895-910 (2007)
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
J Bacteriol 190:7693-8 (2008)
KO pathway

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