KEGG   PATHWAY: vcm03440Help
Entry
vcm03440                    Pathway                                

Name
Homologous recombination - Vibrio cholerae M66-2
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
vcm03440  Homologous recombination
vcm03440

Ortholog table
Module
vcm_M00260  DNA polymerase III complex, bacteria [PATH:vcm03440]
Other DBs
BSID: 96123
GO: 0000724
Organism
Vibrio cholerae M66-2 [GN:vcm]
Gene
VCM66_2340  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
VCM66_0382  ssb; single-strand binding protein [KO:K03111]
VCM66_0014  recF; recF protein [KO:K03629]
VCM66_2382  recO; DNA repair protein RecO [KO:K03584]
VCM66_1011  recR; recombination protein RecR [KO:K06187]
VCM66_0501  recA; recA protein [KO:K03553]
VCM66_0108  polI; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
VCM66_1769  ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
VCM66_1768  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
VCM66_1770  ruvC; crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
VCM66_2631  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
VCM66_2243  recB; exodeoxyribonuclease V, 135 kDa subunit [KO:K03582] [EC:3.1.11.5]
VCM66_2245  recC; exodeoxyribonuclease V, 125 kDa subunit [KO:K03583] [EC:3.1.11.5]
VCM66_2242  recD; exodeoxyribonuclease V, 67 kDa subunit [KO:K03581] [EC:3.1.11.5]
VCM66_2168  dnaE; DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
VCM66_0013  dnaN; DNA polymerase III, beta chain [KO:K02338] [EC:2.7.7.7]
VCM66_1009  dnaZX; DNA polymerase III, gamma/tau subunits [KO:K02343] [EC:2.7.7.7]
VCM66_0909  holA; DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
VCM66_1939  holB; DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
VCM66_0284  putative DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
VCM66_1245  putative DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
VCM66_2156  dnaQ; DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
VCM66_2424  holC; DNA polymerase III, chi subunit [KO:K02339] [EC:2.7.7.7]
VCM66_0614  holD; DNA polymerase III, psi subunit [KO:K02344] [EC:2.7.7.7]
VCM66_2598  priA; primosomal protein N' [KO:K04066] [EC:3.6.4.-]
VCM66_0351  priB; primosomal replication protein N [KO:K02686]
VCM66_1780  priC; primosomal replication protein N'' [KO:K04067]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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