KEGG   PATHWAY: xcc03440Help
Entry
xcc03440                    Pathway                                

Name
Homologous recombination - Xanthomonas campestris pv. campestris ATCC 33913
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
xcc03440  Homologous recombination
xcc03440

Ortholog table
Module
xcc_M00260  DNA polymerase III complex, bacteria [PATH:xcc03440]
Other DBs
BSID: 8338
GO: 0000724
Organism
Xanthomonas campestris pv. campestris ATCC 33913 [GN:xcc]
Gene
XCC1846  recJ; single stranded DNA exonuclease [KO:K07462] [EC:3.1.-.-]
XCC2735  ssb; single-stranded DNA-binding protein [KO:K03111]
XCC0003  recF; recombination protein F [KO:K03629]
XCC1275  recO; DNA repair protein RecO [KO:K03584]
XCC1003  recR; recombination protein RecR [KO:K06187]
XCC1722  recA; recombinase A [KO:K03553]
XCC4020  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
XCC3025  ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
XCC3023  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
XCC3026  ruvC; Holliday junction resolvase [KO:K01159] [EC:3.1.22.4]
XCC3238  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
XCC4199  recB; exodeoxyribonuclease V subunit beta [KO:K03582] [EC:3.1.11.5]
XCC4200  recC; exodeoxyribonuclease V subunit gamma [KO:K03583] [EC:3.1.11.5]
XCC4198  recD; exodeoxyribonuclease V subunit alpha [KO:K03581] [EC:3.1.11.5]
XCC1358  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
XCC0002  dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
XCC1001  dnaX; DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
XCC2617  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
XCC1023  holB; DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
XCC0988  dnaQ; DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
XCC0648  holC; DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
XCC3765  priA; primosome assembly protein PriA [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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