KEGG   PATHWAY: xne02060Help
xne02060                    Pathway                                

Phosphotransferase system (PTS) - Xenorhabdus nematophila ATCC 19061
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the phosphoryl group is transferred to histidine or cysteine residues of EIIB. The sugar is transported through the membrane-bound EIIC and is phosphorylated by the appropriate sugar-specific EIIB.
Environmental Information Processing; Membrane transport
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Pathway map
xne02060  Phosphotransferase system (PTS)

Ortholog table
xne_M00267  PTS system, N-acetylglucosamine-specific II component [PATH:xne02060]
xne_M00270  PTS system, trehalose-specific II component [PATH:xne02060]
xne_M00276  PTS system, mannose-specific II component [PATH:xne02060]
xne_M00283  PTS system, ascorbate-specific II component [PATH:xne02060]
xne_M00303  PTS system, N-acetylmuramic acid-specific II component [PATH:xne02060]
Other DBs
BSID: 155312
GO: 0009401
TC: 4.A
Xenorhabdus nematophila ATCC 19061 [GN:xne]
XNC1_3215  ptsI; PTS family enzyme I and Hpr components, PEP-protein phosphotransferase [KO:K08483] [EC:]
XNC1_3213  ptsH; PTS family Hpr protein, phosphohistidinoprotein-hexose phosphotransferase [KO:K02784]
XNC1_3216  crr; PTS family enzyme IIA component [KO:K02777] [EC:2.7.1.-]
XNC1_1357  nagE; PTS family enzyme IIC (N-terminal); enzyme IIB (center); enzyme IIA (C-terminal), N-acetylglucosamine-specific [KO:K02802 K02803 K02804] [EC:]
XNC1_4589  treB; PTS family enzyme IIBC, trehalose(maltose)-specific [KO:K02818 K02819] [EC:]
XNC1_4343  yfeV; putative PTS family enzyme IIBC with sucrose/glucose-specific domain [KO:K11191 K11192] [EC:]
XNC1_1932  manX; PTS family enzyme IIA (N-terminal); enzyme IIB (C-terminal), mannose-specific [KO:K02793 K02794] [EC:]
XNC1_1933  manY; PTS family enzyme IIC, mannose-specific [KO:K02795]
XNC1_1934  manZ; PTS family enzyme IID, mannose-specific [KO:K02796]
XNC1_2826  putative phosphotransferase enzyme II, A component SgcA [KO:K02821] [EC:]
XNC1_2827  putative sugar phosphotransferase component II B [KO:K02822] [EC:]
XNC1_2828  ulaA; PTS family enzyme IIC, ascorbate-specific [KO:K03475]
XNC1_4051  ptsP; PTS family enzyme I, transcriptional regulator (with NPR and NTR proteins) [KO:K08484] [EC:]
XNC1_4201  npr; NPr, phosphocarrier protein (HPr-like), nitrogen-related [KO:K08485]
XNC1_4198  ptsN; PTS family enzyme IIA, sugar-specific, regulates N metabolism [KO:K02806] [EC:2.7.1.-]
C00022  Pyruvate
C00031  D-Glucose
C00072  Ascorbate
C00074  Phosphoenolpyruvate
C00089  Sucrose
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00124  D-Galactose
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00185  Cellobiose
C00208  Maltose
C00243  Lactose
C00275  D-Mannose 6-phosphate
C00329  D-Glucosamine
C00352  D-Glucosamine 6-phosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00392  Mannitol
C00644  D-Mannitol 1-phosphate
C00689  alpha,alpha'-Trehalose 6-phosphate
C00697  Nitrogen
C00794  D-Sorbitol
C01083  alpha,alpha-Trehalose
C01094  D-Fructose 1-phosphate
C01096  Sorbitol 6-phosphate
C01113  D-Galactose 6-phosphate
C01132  N-Acetyl-D-galactosamine
C01451  Salicin
C01452  Sorbose
C01674  Chitobiose
C01697  Galactitol
C01798  D-Glucoside
C02262  D-Galactosamine
C02713  N-Acetylmuramate
C02888  Sorbose 1-phosphate
C02995  Maltose 6'-phosphate
C03752  2-Amino-2-deoxy-D-gluconate
C04534  6-Phospho-beta-D-glucosyl-(1,4)-D-glucose
C05396  Lactose 6'-phosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C06311  Galactitol 1-phosphate
C06376  N-Acetyl-D-galactosamine 6-phosphate
C06377  D-Galactosamine 6-phosphate
C11544  2-O-(alpha-D-Mannosyl)-D-glycerate
C16186  L-Ascorbate 6-phosphate
C16488  Fructoselysine
C16489  Fructoselysine 6-phosphate
C16688  Sucrose 6-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C16699  2-O-(6-Phospho-alpha-mannosyl)-D-glycerate
C20589  D-Glucosaminate-6-phosphate
C20978  Glucoselysine
C20979  Glucoselysine-6-phosphate
C21152  N,N'-Diacetylchitobiose 6'-phosphate
Darbon E, Galinier A, Le Coq D, Deutscher J.
Phosphotransfer functions mutated Bacillus subtilis HPr-like protein Crh carrying a histidine in the active site.
J Mol Microbiol Biotechnol 3:439-44 (2001)
Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C.
Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.
J Bacteriol 186:2385-92 (2004)
Martin-Verstraete I, Debarbouille M, Klier A, Rapoport G
Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon.
J Mol Biol 214:657-71 (1990)
Kristich CJ, Glekas GD, Ordal GW.
The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis.
Mol Microbiol 47:1353-66 (2003)
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
J Biol Chem 279:5537-48 (2004)
Keseler IM, Collado-Vides J, Gama-Castro S, Ingraham J, Paley S, Paulsen IT, Peralta-Gil M, Karp PD.
EcoCyc: a comprehensive database resource for Escherichia coli.
Nucleic Acids Res 33:D334-7 (2005)
Mukherjee A, Mammel MK, LeClerc JE, Cebula TA.
Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.
J Bacteriol 190:1710-7 (2008)
Brinkkotter A, Kloss H, Alpert C, Lengeler JW.
Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.
Mol Microbiol 37:125-35 (2000)
Tchieu JH, Norris V, Edwards JS, Saier MH Jr.
The complete phosphotranferase system in Escherichia coli.
J Mol Microbiol Biotechnol 3:329-46 (2001)
Kotrba P, Inui M, Yukawa H.
Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism.
J Biosci Bioeng 92:502-17 (2001)
KO pathway

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