KEGG   PATHWAY: ypk03440Help
ypk03440                    Pathway                                

Homologous recombination - Yersinia pestis KIM10+ (biovar Mediaevalis)
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Genetic Information Processing; Replication and repair
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Pathway map
ypk03440  Homologous recombination

Ortholog table
ypk_M00260  DNA polymerase III complex, bacteria [PATH:ypk03440]
Other DBs
BSID: 9237
GO: 0000724
Yersinia pestis KIM10+ (biovar Mediaevalis) [GN:ypk]
y3274  recJ; ssDNA exonuclease [KO:K07462] [EC:3.1.-.-]
y0582  ssb; ssDNA-binding protein [KO:K03111]
y4111  recF; ssDNA and dsDNA binding protein [KO:K03629]
y1299  recO; recO protein [KO:K03584]
y1062  recR; recombination and repair protein [KO:K06187]
y0881  recA; DNA-dependent ATPase, DNA- and ATP-dependent coprotease [KO:K03553]
y3811  polA; DNA polymerase I [KO:K02335] [EC:]
y2253  ruvA; Holliday junction helicase subunit B [KO:K03550] [EC:]
y2252  ruvB; Holliday junction helicase subunit A [KO:K03551] [EC:]
y2254  ruvC; Holliday junction nuclease [KO:K01159] [EC:]
y0105  recG; DNA helicase [KO:K03655] [EC:]
y3164  recB; DNA helicase, ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNA endonuclease [KO:K03582] [EC:]
y3166  recC; DNA helicase, ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNA endonuclease [KO:K03583] [EC:]
y3163  recD; DNA helicase, ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNA endonuclease [KO:K03581] [EC:]
y3120  dnaE; DNA polymerase III, alpha subunit [KO:K02337] [EC:]  putative DNA polymerase III, alpha subunit [KO:K02337] [EC:]
y4112  dnaN; DNA polymerase III, beta-subunit [KO:K02338] [EC:]
y1060  dnaX; DNA polymerase III, tau and gamma subunits [KO:K02343] [EC:]
y1182  holA; DNA polymerase III, delta subunit [KO:K02340] [EC:]
y1765  holB; DNA polymerase III, delta prime subunit [KO:K02341] [EC:]
y3094  dnaQ; DNA polymerase III, epsilon subunit [KO:K02342] [EC:]
y2525  holE; DNA polymerase III, theta subunit [KO:K02345] [EC:]
y0745  holC; DNA polymerase III, chi subunit [KO:K02339] [EC:]
y3752  holD; DNA polymerase III, psi subunit [KO:K02344] [EC:]
y0298  priA; primosomal protein N' [KO:K04066] [EC:3.6.4.-]
y1056  putative primosomal replication protein N [KO:K04067]
Maloisel L, Fabre F, Gangloff S.
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
Mol Cell Biol 28:1373-82 (2008)
Haruta-Takahashi N, Iwasaki H.
[Recombination mediators] Japanese
Seikagaku 79:449-53 (2007)
Ouyang KJ, Woo LL, Ellis NA.
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
Mech Ageing Dev 129:425-40 (2008)
Kawabata M, Kawabata T, Nishibori M.
Role of recA/RAD51 family proteins in mammals.
Acta Med Okayama 59:1-9 (2005)
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
Mitotic recombination in Saccharomyces cerevisiae.
Curr Genet 42:185-98 (2003)
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
Rad54: the Swiss Army knife of homologous recombination?
Nucleic Acids Res 34:4115-25 (2006)
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
Recombination proteins and rescue of arrested replication forks.
DNA Repair (Amst) 6:967-80 (2007)
KO pathway

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