KEGG   PATHWAY: ypu00270
Entry
ypu00270                    Pathway                                
Name
Cysteine and methionine metabolism - Yersinia pseudotuberculosis MD67
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
ypu00270  Cysteine and methionine metabolism
ypu00270

Module
ypu_M00017  Methionine biosynthesis, aspartate => homoserine => methionine [PATH:ypu00270]
ypu_M00021  Cysteine biosynthesis, serine => cysteine [PATH:ypu00270]
ypu_M00034  Methionine salvage pathway [PATH:ypu00270]
Other DBs
GO: 0006534 0006555
Organism
Yersinia pseudotuberculosis MD67 [GN:ypu]
Gene
BZ21_3408  cysE; serine O-acetyltransferase [KO:K00640] [EC:2.3.1.30]
BZ21_2019  cysK; cysteine synthase A [KO:K01738] [EC:2.5.1.47]
BZ21_213  pyridoxal-phosphate dependent enzyme family protein [KO:K01738] [EC:2.5.1.47]
BZ21_2665  metC; cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]
BZ21_3707  metC; cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]
BZ21_2031  C-S lyase family protein [KO:K14155] [EC:4.4.1.13]
BZ21_1481  C-S lyase family protein [KO:K14155] [EC:4.4.1.13]
BZ21_2975  metH; methionine synthase [KO:K00548] [EC:2.1.1.13]
BZ21_3605  metE; 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase [KO:K00549] [EC:2.1.1.14]
BZ21_2488  metK; methionine adenosyltransferase [KO:K00789] [EC:2.5.1.6]
BZ21_4103  speD; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
BZ21_4104  speE; spermidine synthase [KO:K00797] [EC:2.5.1.16]
BZ21_1795  esaI; acyl-homoserine-lactone synthase [KO:K22956] [EC:2.3.1.184]
BZ21_2539  esaI; acyl-homoserine-lactone synthase [KO:K22956] [EC:2.3.1.184]
BZ21_4131  mtnN; MTA/SAH nucleosidase [KO:K01243] [EC:3.2.2.9]
BZ21_123  mtnK; S-methyl-5-thioribose kinase [KO:K00899] [EC:2.7.1.100]
BZ21_88  multi-copper polyphenol oxidoreductase laccase family protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
BZ21_122  mtnA; S-methyl-5-thioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
BZ21_119  mtnB; methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
BZ21_120  mtnC; 2,3-diketo-5-methylthio-1-phosphopentane phosphatase [KO:K09880] [EC:3.1.3.77]
BZ21_121  mtnD; acireductone dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]
BZ21_3747  tyrB; aromatic-amino-acid aminotransferase [KO:K00832] [EC:2.6.1.57]
BZ21_1665  yebR; protein yebR [KO:K08968] [EC:1.8.4.14]
BZ21_758  C-5 cytosine-specific DNA methylase family protein [KO:K00558] [EC:2.1.1.37]
BZ21_37  luxS; S-ribosylhomocysteine lyase [KO:K07173] [EC:4.4.1.21]
BZ21_2972  aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]
BZ21_3984  aspartate kinase domain protein [KO:K12524] [EC:2.7.2.4 1.1.1.3]
BZ21_3448  aspartate kinase domain protein [KO:K12525] [EC:2.7.2.4 1.1.1.3]
BZ21_3127  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BZ21_2980  metA; homoserine O-succinyltransferase [KO:K00651] [EC:2.3.1.46 2.3.1.31]
BZ21_3447  metB; O-succinylhomoserine (thiol)-lyase [KO:K01739] [EC:2.5.1.48]
BZ21_3485  ilvE; branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
BZ21_36  gshA; glutamate--cysteine ligase [KO:K01919] [EC:6.3.2.2]
BZ21_2492  gshB; glutathione synthase [KO:K01920] [EC:6.3.2.3]
BZ21_712  aspC; aspartate aminotransferase [KO:K00813] [EC:2.6.1.1]
BZ21_504  rhodanese-like domain protein [KO:K01011] [EC:2.8.1.1 2.8.1.2]
BZ21_1921  aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]
BZ21_1681  alr; alanine racemase [KO:K25317] [EC:5.1.1.10]
BZ21_1070  dcyD; D-cysteine desulfhydrase [KO:K05396] [EC:4.4.1.15]
BZ21_3834  mdh; malate dehydrogenase, NAD-dependent [KO:K00024] [EC:1.1.1.37]
BZ21_997  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BZ21_2036  cysM; cysteine synthase B [KO:K12339] [EC:2.5.1.144]
BZ21_594  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BZ21_2474  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BZ21_691  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
ypu00010  Glycolysis / Gluconeogenesis
ypu00250  Alanine, aspartate and glutamate metabolism
ypu00260  Glycine, serine and threonine metabolism
ypu00290  Valine, leucine and isoleucine biosynthesis
ypu00430  Taurine and hypotaurine metabolism
ypu00480  Glutathione metabolism
ypu00620  Pyruvate metabolism
ypu00640  Propanoate metabolism
ypu00770  Pantothenate and CoA biosynthesis
ypu00900  Terpenoid backbone biosynthesis
ypu00920  Sulfur metabolism
KO pathway
ko00270   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (45)   
   KEGG GENES (45)   
All databases (46)   

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