KEGG   PATHWAY: ypy02060Help
ypy02060                    Pathway                                

Phosphotransferase system (PTS) - Yersinia pseudotuberculosis YPIII
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the phosphoryl group is transferred to histidine or cysteine residues of EIIB. The sugar is transported through the membrane-bound EIIC and is phosphorylated by the appropriate sugar-specific EIIB.
Environmental Information Processing; Membrane transport
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ypy02060  Phosphotransferase system (PTS)

Ortholog table
ypy_M00265  PTS system, glucose-specific II component [PATH:ypy02060]
ypy_M00267  PTS system, N-acetylglucosamine-specific II component [PATH:ypy02060]
ypy_M00270  PTS system, trehalose-specific II component [PATH:ypy02060]
ypy_M00273  PTS system, fructose-specific II component [PATH:ypy02060]
ypy_M00274  PTS system, mannitol-specific II component [PATH:ypy02060]
ypy_M00275  PTS system, cellobiose-specific II component [PATH:ypy02060]
ypy_M00276  PTS system, mannose-specific II component [PATH:ypy02060]
ypy_M00277  PTS system, N-acetylgalactosamine-specific II component [PATH:ypy02060]
ypy_M00283  PTS system, ascorbate-specific II component [PATH:ypy02060]
Other DBs
BSID: 65015
GO: 0009401
TC: 4.A
Yersinia pseudotuberculosis YPIII [GN:ypy]
YPK_3657  phosphoenolpyruvate-protein phosphotransferase [KO:K08483 K11189 K11201] [EC: 2.7.1.-]
YPK_1427  phosphoenolpyruvate-protein phosphotransferase [KO:K08483] [EC:]
YPK_1428  Phosphotransferase system, phosphocarrier protein HPr [KO:K02784]
YPK_1426  PTS system, glucose subfamily, IIA subunit [KO:K02777] [EC:2.7.1.-]
YPK_1694  PTS system, glucose-specific IIBC subunit [KO:K02778 K02779] [EC:]
YPK_0974  phosphotransferase system PTS EIIB protein [KO:K02778] [EC:]
YPK_2996  PTS system, N-acetylglucosamine-specific IIBC subunit [KO:K02802 K02803 K02804] [EC:]
YPK_0495  PTS system, trehalose-specific IIBC subunit [KO:K02818 K02819] [EC:]
YPK_0026  PTS system, mannitol-specific IIC subunit [KO:K02798 K02799 K02800] [EC:]
YPK_1146  phosphotransferase system PTS lactose/cellobiose-specific IIA subunit [KO:K02759] [EC:]
YPK_1144  phosphotransferase system lactose/cellobiose-specific IIB subunit [KO:K02760] [EC:]
YPK_1145  PTS system, lactose/cellobiose family IIC subunit [KO:K02761]
YPK_2464  PTS system, mannose/fructose/sorbose family, IIB subunit [KO:K02793 K02794] [EC:]
YPK_2465  PTS system, mannose/fructose/sorbose family, IIC subunit [KO:K02795]
YPK_2466  PTS system, mannose/fructose/sorbose family, IID subunit [KO:K02796]
YPK_0989  PTS system fructose subfamily IIA component [KO:K02744] [EC:2.7.1.-]
YPK_0992  PTS system, mannose/fructose/sorbose family, IIB subunit [KO:K02745] [EC:2.7.1.-]
YPK_0991  phosphotransferase system PTS sorbose-specific IIC subunit [KO:K02746]
YPK_0990  PTS system mannose/fructose/sorbose family IID component [KO:K02747]
YPK_1548  putative PTS IIA-like nitrogen-regulatory protein PtsN [KO:K02821] [EC:]
YPK_1547  phosphotransferase system lactose/cellobiose-specific IIB subunit [KO:K02822] [EC:]
YPK_1546  putative sugar-specific permease SgaT/UlaA [KO:K03475]
YPK_2764  phosphocarrier, HPr family [KO:K02768 K11183] [EC:]
YPK_2762  PTS system, fructose subfamily, IIC subunit [KO:K02769 K02770] [EC:]
YPK_1034  PTSINtr with GAF domain, PtsP [KO:K08484] [EC:]
YPK_0501  Phosphotransferase system, phosphocarrier protein HPr [KO:K08485]
YPK_0503  PTS IIA-like nitrogen-regulatory protein PtsN [KO:K02806] [EC:2.7.1.-]
C00022  Pyruvate
C00031  D-Glucose
C00072  Ascorbate
C00074  Phosphoenolpyruvate
C00089  Sucrose
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00124  D-Galactose
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00185  Cellobiose
C00208  Maltose
C00243  Lactose
C00275  D-Mannose 6-phosphate
C00329  D-Glucosamine
C00352  D-Glucosamine 6-phosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00392  Mannitol
C00644  D-Mannitol 1-phosphate
C00689  alpha,alpha'-Trehalose 6-phosphate
C00697  Nitrogen
C00794  D-Sorbitol
C01083  alpha,alpha-Trehalose
C01094  D-Fructose 1-phosphate
C01096  Sorbitol 6-phosphate
C01113  D-Galactose 6-phosphate
C01132  N-Acetyl-D-galactosamine
C01451  Salicin
C01452  Sorbose
C01674  Chitobiose
C01697  Galactitol
C01798  D-Glucoside
C02262  D-Galactosamine
C02713  N-Acetylmuramate
C02888  Sorbose 1-phosphate
C02995  Maltose 6'-phosphate
C03752  2-Amino-2-deoxy-D-gluconate
C04534  6-Phospho-beta-D-glucosyl-(1,4)-D-glucose
C05396  Lactose 6'-phosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C06311  Galactitol 1-phosphate
C06376  N-Acetyl-D-galactosamine 6-phosphate
C06377  D-Galactosamine 6-phosphate
C11544  2-O-(alpha-D-Mannosyl)-D-glycerate
C16186  L-Ascorbate 6-phosphate
C16488  Fructoselysine
C16489  Fructoselysine 6-phosphate
C16688  Sucrose 6-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C16699  2-O-(6-Phospho-alpha-mannosyl)-D-glycerate
C20589  D-Glucosaminate-6-phosphate
C20978  Glucoselysine
C20979  Glucoselysine-6-phosphate
C21152  N,N'-Diacetylchitobiose 6'-phosphate
Darbon E, Galinier A, Le Coq D, Deutscher J.
Phosphotransfer functions mutated Bacillus subtilis HPr-like protein Crh carrying a histidine in the active site.
J Mol Microbiol Biotechnol 3:439-44 (2001)
Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C.
Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.
J Bacteriol 186:2385-92 (2004)
Martin-Verstraete I, Debarbouille M, Klier A, Rapoport G
Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon.
J Mol Biol 214:657-71 (1990)
Kristich CJ, Glekas GD, Ordal GW.
The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis.
Mol Microbiol 47:1353-66 (2003)
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
J Biol Chem 279:5537-48 (2004)
Keseler IM, Collado-Vides J, Gama-Castro S, Ingraham J, Paley S, Paulsen IT, Peralta-Gil M, Karp PD.
EcoCyc: a comprehensive database resource for Escherichia coli.
Nucleic Acids Res 33:D334-7 (2005)
Mukherjee A, Mammel MK, LeClerc JE, Cebula TA.
Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.
J Bacteriol 190:1710-7 (2008)
Brinkkotter A, Kloss H, Alpert C, Lengeler JW.
Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.
Mol Microbiol 37:125-35 (2000)
Tchieu JH, Norris V, Edwards JS, Saier MH Jr.
The complete phosphotranferase system in Escherichia coli.
J Mol Microbiol Biotechnol 3:329-46 (2001)
Kotrba P, Inui M, Yukawa H.
Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism.
J Biosci Bioeng 92:502-17 (2001)
KO pathway

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