KEGG   PATHWAY: zpr03440Help
Entry
zpr03440                    Pathway                                

Name
Homologous recombination - Zunongwangia profunda
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
zpr03440  Homologous recombination
zpr03440

Ortholog table
Module
zpr_M00260  DNA polymerase III complex, bacteria [PATH:zpr03440]
Other DBs
BSID: 148081
GO: 0000724
Organism
Zunongwangia profunda [GN:zpr]
Gene
ZPR_0236  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
ZPR_4015  single-stranded DNA-binding protein [KO:K03111]
ZPR_4580  single-stranded DNA-binding protein [KO:K03111]
ZPR_4269  single-strand binding protein [KO:K03111]
ZPR_4270  single-strand binding protein [KO:K03111]
ZPR_1454  DNA replication and repair protein RecF [KO:K03629]
ZPR_0161  DNA repair protein RecO [KO:K03584]
ZPR_1233  recombination protein RecR [KO:K06187]
ZPR_0086  RecA [KO:K03553]
ZPR_0517  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
ZPR_0589  Holliday junction ATP-dependent DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
ZPR_0585  Holliday junction DNA helicase B [KO:K03551] [EC:3.6.4.12]
ZPR_4298  Holliday junction resolvase [KO:K01159] [EC:3.1.22.4]
ZPR_1202  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
ZPR_4431  DNA polymerase III subunit alpha-1 [KO:K02337] [EC:2.7.7.7]
ZPR_0635  DNA polymerase III subunit alpha-2 [KO:K02337] [EC:2.7.7.7]
ZPR_1831  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
ZPR_1914  DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
ZPR_3066  DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
ZPR_0035  DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
ZPR_1839  exonuclease family protein [KO:K02342] [EC:2.7.7.7]
ZPR_1504  exonuclease domain-containing protein [KO:K02342] [EC:2.7.7.7]
ZPR_3579  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
ZPR_3233  exonuclease family protein [KO:K02342] [EC:2.7.7.7]
ZPR_1236  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
ZPR_2118  primosomal protein N' (replication factor Y) [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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