KEGG   PATHWAY: bbo03013
Entry
bbo03013                    Pathway                                
Name
Nucleocytoplasmic transport - Babesia bovis
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
bbo03013  Nucleocytoplasmic transport
bbo03013

Other DBs
GO: 0050658
Organism
Babesia bovis [GN:bbo]
Gene
BBOV_IV000400  DEAD/DEAH box helicase family protein [KO:K18655] [EC:5.6.2.7]
BBOV_IV001150  WD domain G-beta repeat family protein [KO:K14298]
BBOV_III008340  Nucleoporin autopeptidase family protein [KO:K14297]
BBOV_I005050  ubiquitin conjugating enzyme family protein [KO:K10577]
BBOV_I005060  ubiquitin conjugating enzyme family protein [KO:K10577]
BBOV_III003640  WD domain G-beta repeat family protein [KO:K14004]
BBOV_III003670  WD domain G-beta repeat family protein [KO:K14004]
BBOV_III006030  hypothetical protein [KO:K14306]
BBOV_I003210  uncharacterized protein [KO:K14314]
BBOV_II007610  hypothetical protein [KO:K20724]
BBOV_III009880  armadillo/beta-catenin-like repeat domain containing protein [KO:K15042]
BBOV_IV000520  putative importin beta subunit [KO:K14293]
BBOV_II003640  HEAT-like repeat family protein [KO:K18727]
BBOV_II006130  hypothetical protein [KO:K15436]
BBOV_IV004650  uncharacterized protein [KO:K20222]
BBOV_III003740  Importin-beta N-terminal domain family protein [KO:K20223]
BBOV_IV011640  snurportin-1 [KO:K13151]
BBOV_II007220  CRM1 exportin C terminal family protein [KO:K14290]
BBOV_II004290  CAS/CSE protein C-terminus family protein [KO:K18423]
BBOV_II002360  hypothetical protein [KO:K18460]
BBOV_IV010920  putative GTP-binding nuclear protein GSP1/CNR1 [KO:K07936]
BBOV_IV010620  putative translation elongation factor EF-1 subunit alpha [KO:K03231]
BBOV_IV010630  putative translation elongation factor EF-1 subunit alpha [KO:K03231]
BBOV_IV006210  uncharacterized protein [KO:K12882]
BBOV_IV008110  RNA recognition motif domain containing protein [KO:K12883]
BBOV_IV009430  NMD3 nonsense-mediated mRNA decay family protein [KO:K07562]
BBOV_III001870  RNA recognition motif domain containing protein [KO:K12876]
BBOV_II003590  Mago_nashi superfamily protein [KO:K12877]
BBOV_IV010990  DEAD/DEAH box helicase family protein [KO:K13025] [EC:5.6.2.7]
BBOV_IV002750  eIF-4A-like DEAD family RNA helicase family protein [KO:K12812] [EC:5.6.2.7]
BBOV_III006320  PWI domain family protein [KO:K13171]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
bbo03015  mRNA surveillance pathway
KO pathway
ko03013   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (31)   
   KEGG GENES (31)   
All databases (32)   

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