KEGG   PATHWAY: bmy03060
Entry
bmy03060                    Pathway                                
Name
Protein export - Brugia malayi (filaria)
Description
The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
bmy03060  Protein export
bmy03060

Other DBs
GO: 0043952 0043953
Organism
Brugia malayi (filaria) [GN:bmy]
Gene
BM_BM12987  Bm12987; 60Kd inner membrane protein [KO:K03217]
BM_BM1859  Bma-oxa-1; 60Kd inner membrane protein [KO:K03217]
BM_BM13763  Bm13763; signal recognition particle 54 kDa protein (SRP54), putative [KO:K03106] [EC:3.6.5.4]
BM_BM13841  Bm13841; Uncharacterized protein [KO:K10956]
BM_BM14070  Bm14070; Protein transport protein SEC61 beta subunit, putative [KO:K09481]
BM_BM14080  Bma-emo-1.1; Protein transport protein SEC61 gamma subunit, putative [KO:K07342]
BM_BM17215  Bma-emo-1.2; Uncharacterized protein [KO:K07342]
BM_BM2303  Bm2303; Uncharacterized protein [KO:K12275]
BM_BM6961  Bma-dnj-29; Uncharacterized protein [KO:K09540]
BM_BM13661  Bm13661; Heat shock 70 kDa protein C precursor, putative [KO:K09490] [EC:3.6.4.10]
BM_BM7482  Bm7482; signal recognition particle 9 kDa protein homolog, putative [KO:K03109]
BM_BM3580  Bm3580; Uncharacterized protein [KO:K03104]
BM_BM3196  Bma-srpa-72; TPR Domain containing protein [KO:K03108]
BM_BM4416  Bma-srpa-68; Uncharacterized protein [KO:K03107]
BM_BM3901  Bm3901; Signal recognition particle 19 kDa protein, putative [KO:K03105]
BM_BM3902  Bm3902; signal recognition particle receptor alpha subunit, putative [KO:K13431]
BM_BM13989  Bma-asna-1; Uncharacterized protein [KO:K01551] [EC:7.3.2.7 7.3.-.-]
BM_BM9910  Bma-cee-1; Uncharacterized protein [KO:K23387]
BM_BM5228  Bma-sgt-1; TPR Domain containing protein [KO:K16365]
BM_BM5222  Bm5222; HSPC171 protein, putative [KO:K27164]
BM_BM2553  Bm2553; microsomal signal peptidase 12 kDa subunit, putative [KO:K12946] [EC:3.4.-.-]
BM_BM6381  Bma-hpo-21; Conserved hypothetical protein, putative [KO:K12947] [EC:3.4.-.-]
BM_BM14054  Bm14054; Signal peptidase subunit family protein [KO:K12948] [EC:3.4.-.-]
BM_BM6804  Bm6804; Uncharacterized protein [KO:K13280] [EC:3.4.21.89]
BM_BM2349  Bma-immp-1; Peptidase S24-like domain containing protein [KO:K09647] [EC:3.4.21.-]
Reference
PMID:10087917
  Authors
Dalbey RE, Robinson C.
  Title
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
  Journal
Trends Biochem Sci 24:17-22 (1999)
DOI:10.1016/S0968-0004(98)01333-4
Reference
PMID:10652088
  Authors
Berks BC, Sargent F, Palmer T.
  Title
The Tat protein export pathway.
  Journal
Mol Microbiol 35:260-74 (2000)
DOI:10.1046/j.1365-2958.2000.01719.x
Reference
PMID:10747959
  Authors
Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
  Title
TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
  Journal
J Biol Chem 275:16717-22 (2000)
DOI:10.1074/jbc.M000800200
Reference
PMID:11007775
  Authors
Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
  Title
TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
  Journal
J Biol Chem 275:41350-7 (2000)
DOI:10.1074/jbc.M004887200
Reference
PMID:18046402
  Authors
Rapoport TA
  Title
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
  Journal
Nature 450:663-9 (2007)
DOI:10.1038/nature06384
Reference
PMID:17368028
  Authors
Flower AM
  Title
The SecY translocation complex: convergence of genetics and structure.
  Journal
Trends Microbiol 15:203-10 (2007)
DOI:10.1016/j.tim.2007.03.001
Reference
PMID:16212506
  Authors
Osborne AR, Rapoport TA, van den Berg B
  Title
Protein translocation by the Sec61/SecY channel.
  Journal
Annu Rev Cell Dev Biol 21:529-50 (2005)
DOI:10.1146/annurev.cellbio.21.012704.133214
Reference
PMID:12475201
  Authors
Paetzel M, Karla A, Strynadka NC, Dalbey RE
  Title
Signal peptidases.
  Journal
Chem Rev 102:4549-80 (2002)
DOI:10.1021/cr010166y
Reference
PMID:10924740
  Authors
Paetzel M, Dalbey RE, Strynadka NC
  Title
The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
  Journal
Pharmacol Ther 87:27-49 (2000)
DOI:10.1016/S0163-7258(00)00064-4
Reference
PMID:17259602
  Authors
Ng SY, Chaban B, VanDyke DJ, Jarrell KF
  Title
Archaeal signal peptidases.
  Journal
Microbiology 153:305-14 (2007)
DOI:10.1099/mic.0.2006/003087-0
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03060   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG GENES (25)   
All databases (26)   

Download RDF
DBGET integrated database retrieval system