KEGG   PATHWAY: bmy03420
Entry
bmy03420                    Pathway                                
Name
Nucleotide excision repair - Brugia malayi (filaria)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
bmy03420  Nucleotide excision repair
bmy03420

Other DBs
GO: 0006289
Organism
Brugia malayi (filaria) [GN:bmy]
Gene
BM_BM14000  Bma-rbx-1; hyperosmotic protein 21, putative [KO:K03868] [EC:2.3.2.32]
BM_BM4110  Bma-cul-4; Cullin family protein [KO:K10609]
BM_BM5114  Bma-ddb-1; Uncharacterized protein [KO:K10610]
BM_BM7416  Bma-rad-23; Uncharacterized protein [KO:K10839]
BM_BM8942  Bm8942; Uncharacterized protein [KO:K10570]
BM_BM12922  Bm12922; Uncharacterized protein [KO:K10841]
BM_BM7543  Bma-uvs-1; uncharacterized protein [KO:K23720]
BM_BM3864  Bma-ama-1; Uncharacterized protein [KO:K03006] [EC:2.7.7.6]
BM_BM12315  Bma-rpb-3; DNA-directed RNA polymerase II 33 kDa polypeptide, putative [KO:K03011]
BM_BM4057  Bma-rpb-4; DNA-directed RNA polymerase II 16 kDa polypeptide, putative [KO:K03012]
BM_BM14030  Bma-rpb-5; Uncharacterized protein [KO:K03013]
BM_BM14058  Bma-rpb-6; Uncharacterized protein [KO:K03014]
BM_BM6805  Bma-rpb-7; Uncharacterized protein [KO:K03015]
BM_BM14056  Bma-rpb-8; DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide, putative [KO:K03016]
BM_BM7209  Bma-rpb-9; Uncharacterized protein [KO:K03017]
BM_BM6394  Bma-rpb-10; DNA-directed RNA polymerase II 7.6 kDa polypeptide, putative [KO:K03007]
BM_BM3534  Bma-rpb-12; Uncharacterized protein [KO:K03009]
BM_BM13749  Bma-cdk-7.2; cyclin-dependent kinase 7 homolog, putative [KO:K02202] [EC:2.7.11.22 2.7.11.23]
BM_BM4320  Bma-mnat-1; Uncharacterized protein [KO:K10842]
BM_BM6697  Bma-cyh-1; Cyclin, N-terminal domain containing protein [KO:K06634]
BM_BM13812  Bma-xpb-1; helicase, putative [KO:K10843] [EC:5.6.2.4]
BM_BM6839  Bm6839; REX1 DNA Repair family protein [KO:K10845]
BM_BM5177  Bm5177; BSD domain containing protein [KO:K03141]
BM_BM7634  Bm7634; Uncharacterized protein [KO:K03143]
BM_BM7120  Bm7120; Uncharacterized protein [KO:K03144]
BM_BM4887  Bma-xpa-1; XPA protein N-terminal containing protein [KO:K10847]
BM_BM9861  Bm9861; replication factor A 73 kDa subunit, putative [KO:K07466]
BM_BM8916  Bm8916; uncharacterized protein [KO:K10739]
BM_BM2813  Bma-xpf-1; ERCC4 domain containing protein [KO:K10848] [EC:3.1.-.-]
BM_BM13796  Bm13796; DNA polymerase delta catalytic subunit, putative [KO:K02327] [EC:2.7.7.7]
BM_BM13974  Bm13974; pold2-prov protein, putative [KO:K02328]
BM_BM394  Bm394; Uncharacterized protein [KO:K03504]
BM_BM3809  Bma-pole-1; DNA polymerase family B, exonuclease domain containing protein [KO:K02324] [EC:2.7.7.7]
BM_BM3181  Bma-pole-2.2; DNA polymerase epsilon subunit B, putative [KO:K02325] [EC:2.7.7.7]
BM_BM14683  Bma-pole-2.1; pole2 protein, putative [KO:K02325] [EC:2.7.7.7]
BM_BM9269  Bm9269; DNA polymerase epsilon p17 subunit, putative [KO:K02326] [EC:2.7.7.7]
BM_BM9124  Bm9124; DNA polymerase epsilon p17 subunit, putative [KO:K02326] [EC:2.7.7.7]
BM_BM6156  Bma-pcn-1; proliferating cell nuclear antigen (PCNA), putative [KO:K04802]
BM_BM13798  Bma-rfc-4; replication factor C, 37kDa subunit, putative [KO:K10755]
BM_BM13799  Bma-rfc-2; Activator 1 40 kDa subunit, putative [KO:K10755]
BM_BM13932  Bma-rfc-3; Activator 1 38 kDa subunit (Replication factor C 38 kDa subunit), putative [KO:K10756]
BM_BM2459  Bma-lig-1; DNA ligase, putative [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
bmy03020  RNA polymerase
bmy04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (42)   
   KEGG GENES (42)   
All databases (43)   

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