KEGG   PATHWAY: bmy04150
Entry
bmy04150                    Pathway                                
Name
mTOR signaling pathway - Brugia malayi (filaria)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
bmy04150  mTOR signaling pathway
bmy04150

Organism
Brugia malayi (filaria) [GN:bmy]
Gene
BM_BM13836  Bm13836; vacuolar ATP synthase subunit B, putative [KO:K02147]
BM_BM8670  Bm8670; Uncharacterized protein [KO:K02148]
BM_BM13998  Bma-vha-11; Uncharacterized protein [KO:K02148]
BM_BM13883  Bma-vha-14; vacuolar ATP synthase subunit D, putative [KO:K02149]
BM_BM13886  Bma-vha-8; Uncharacterized protein [KO:K02150]
BM_BM14064  Bma-vha-9; Vacuolar ATP synthase subunit F, putative [KO:K02151]
BM_BM13908  Bma-vha-10; vacuolar ATP synthase subunit G, putative [KO:K02152]
BM_BM5791  Bma-vha-15; Uncharacterized protein [KO:K02144]
BM_BM8791  Bm8791; Josephin family protein [KO:K20397]
BM_BM7211  Bm7211; Uncharacterized protein [KO:K20398]
BM_BM10547  Bma-lmtr-3; uncharacterized protein [KO:K04370]
BM_BM10217  Bm10217; Uncharacterized protein [KO:K20399]
BM_BM10044  Bm10044; Uncharacterized protein [KO:K16344]
BM_BM3513  Bma-flcn-1; uncharacterized protein [KO:K09594]
BM_BM5538  Bm5538; Uncharacterized protein [KO:K20401]
BM_BM5988  Bma-raga-1; GTP-binding protein GTR1, putative [KO:K16185]
BM_BM6343  Bma-ragc-1; Gtr1/RagA G protein conserved region containing protein [KO:K16186]
BM_BM10934  Bm10934; Uncharacterized protein [KO:K20407]
BM_BM6538  Bma-npp-18; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I family protein [KO:K14299]
BM_BM6359  Bm6359; Uncharacterized protein [KO:K20408]
BM_BM12153  Bm12153; Uncharacterized protein [KO:K20409]
BM_BM7155  Bma-npp-20; Uncharacterized protein [KO:K14004]
BM_BM5670  Bm5670; DEP domain containing protein 5, putative [KO:K20404]
BM_BM4228  Bma-nprl-2; Uncharacterized protein [KO:K20405]
BM_BM3852  Bma-nprl-3; alpha globin regulatory element containing gene, putative [KO:K20406]
BM_BM2128  Bma-daf-15; uncharacterized protein [KO:K07204]
BM_BM1727  Bm1727; Uncharacterized protein [KO:K07203] [EC:2.7.11.1]
BM_BM2147  Bma-mlst-8; Uncharacterized protein [KO:K08266]
BM_BM9994  Bma-clk-2; Uncharacterized protein [KO:K11137]
BM_BM5338  Bm5338; uncharacterized protein [KO:K20403]
BM_BM4691  Bma-lpin-1; Uncharacterized protein [KO:K15728] [EC:3.1.3.4]
BM_BM6939  Bma-unc-51; Uncharacterized protein [KO:K08269] [EC:2.7.11.1]
BM_BM1769  Bma-ife-3; Uncharacterized protein [KO:K03259]
BM_BM5201  Bm5201; eukaryotic translation initiation factor 4E-1, putative [KO:K03259]
BM_BM1973  Bma-ife-4; Uncharacterized protein [KO:K03259]
BM_BM6597  Bma-rsks-1; Uncharacterized protein [KO:K04688] [EC:2.7.11.1]
BM_BM13882  Bma-rps-6; Uncharacterized protein [KO:K02991]
BM_BM6742  Bma-strd-1; Uncharacterized protein [KO:K08271]
BM_BM6930  Bma-par-4; Uncharacterized protein [KO:K07298] [EC:2.7.11.1]
BM_BM13872  Bm13872; Uncharacterized protein [KO:K08272]
BM_BM5465  Bma-aak-2; Uncharacterized protein [KO:K07198] [EC:2.7.11.31]
BM_BM9251  Bm9251; Uncharacterized protein [KO:K07206]
BM_BM9160  Bm9160; Uncharacterized protein [KO:K20396]
BM_BM4347  Bma-rheb-1; Uncharacterized protein [KO:K07208]
BM_BM7824  Bm7824; wnt family protein [KO:K00182]
BM_BM4974  Bma-cwn-1; Wnt-4 protein precursor, putative [KO:K00408]
BM_BM6232  Bma-egl-20; wnt family protein [KO:K01558]
BM_BM5945  Bma-mom-5; Uncharacterized protein [KO:K02432]
BM_BM3658  Bma-cfz-2; Uncharacterized protein [KO:K02375]
BM_BM7044  Bma-lin-17; Uncharacterized protein [KO:K02842]
BM_BM5564  Bm5564; Uncharacterized protein [KO:K03068]
BM_BM2592  Bm2592; Domain found in Dishevelled, Egl-10, and Pleckstrin family protein [KO:K02353]
BM_BM17519  Bm17519; Uncharacterized protein [KO:K03083] [EC:2.7.11.26]
BM_BM6312  Bm6312; Uncharacterized protein [KO:K03083] [EC:2.7.11.26]
BM_BM2205  Bma-sem-5; Uncharacterized protein [KO:K04364]
BM_BM6081  Bma-sos-1; Uncharacterized protein [KO:K03099]
BM_BM16898  Bma-let-60; Uncharacterized protein [KO:K07827]
BM_BM7093  Bma-lin-45; Uncharacterized protein [KO:K04365] [EC:2.7.11.1]
BM_BM6799  Bma-mek-2; Uncharacterized protein [KO:K04368] [EC:2.7.12.2]
BM_BM4047  Bma-mpk-1; Uncharacterized protein [KO:K04371] [EC:2.7.11.24]
BM_BM8603  Bma-rskn-1; ribosomal protein S6 kinase alpha 3, putative [KO:K04373] [EC:2.7.11.1]
BM_BM2926  Bma-ist-1; PH domain containing protein [KO:K16172]
BM_BM7280  Bma-aap-1; Uncharacterized protein [KO:K02649]
BM_BM1757  Bma-age-1; Phosphatidylinositol 3- and 4-kinase family protein [KO:K00922] [EC:2.7.1.153]
BM_BM5630  Bma-daf-18; Uncharacterized protein [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
BM_BM4698  Bma-pdk-1; Uncharacterized protein [KO:K06276] [EC:2.7.11.1]
BM_BM2161  Bma-akt-1; Uncharacterized protein [KO:K04456] [EC:2.7.11.1]
BM_BM3344  Bma-sinh-1; PAP2 superfamily protein [KO:K20410]
BM_BM3692  Bm3692; AVO3, putative [KO:K08267]
BM_BM6727  Bm6727; RAS-like GTP-binding protein RhoA, putative [KO:K04513]
BM_BM10155  Bma-rho-1.1; RAS-like GTP-binding protein RhoA, putative [KO:K04513]
BM_BM9534  Bma-rho-1.2; Uncharacterized protein [KO:K04513]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
bmy00561  Glycerolipid metabolism
bmy04010  MAPK signaling pathway
bmy04140  Autophagy - animal
KO pathway
ko04150   

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Genome (1)   
   KEGG GENOME (1)   
Gene (72)   
   KEGG GENES (72)   
All databases (73)   

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