KEGG PATHWAY: bmy04330

PATHWAY: bmy04330

Entry

bmy04330                    Pathway

Name

Notch signaling pathway - Brugia malayi (filaria)

Description

The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.

Class

Environmental Information Processing; Signal transduction

Pathway map

bmy04330

Notch signaling pathway

Other DBs

GO:

0007219

Organism

Brugia malayi (filaria) [GN:bmy]

Gene

BM_BM4897

Bma-lag-1; Uncharacterized protein [KO:K06053]

BM_BM2592

Bm2592; Domain found in Dishevelled, Egl-10, and Pleckstrin family protein [KO:K02353]

BM_BM7430

Bma-adm-4; Uncharacterized protein [KO:K06059] [EC:3.4.24.86]

BM_BM3856

Bma-sel-12; Presenilin family protein [KO:K04505] [EC:3.4.23.-]

BM_BM7487

Bma-spe-4.1; Presenilin spe-4, putative [KO:K04505] [EC:3.4.23.-]

BM_BM6069

Bma-pen-2; gamma-secretase subunit pen-2, putative [KO:K06170]

BM_BM980

Bma-aph-2.1; Uncharacterized protein [KO:K06171]

BM_BM6088

Bma-aph-1; gamma-secretase subunit aph-1, putative [KO:K06172]

BM_BM5327

Bma-cbp-1; TAZ zinc finger family protein [KO:K04498] [EC:2.3.1.48]

BM_BM6616

Bma-pcaf-1; Uncharacterized protein [KO:K06062] [EC:2.3.1.48]

BM_BM6051

Bma-skp-1; putative 60.2 kDa protein T27F2.1 in chromosome V, putative [KO:K06063]

BM_BM4231

Bma-ctbp-1; Uncharacterized protein [KO:K04496] [EC:1.1.1.428]

BM_BM6137

Bma-unc-37; Uncharacterized protein [KO:K04497]

BM_BM8923

Bma-hda-3; histone deacetylase 1 (HD1), putative [KO:K06067] [EC:3.5.1.98]

BM_BM13833

Bma-hda-1; Histone deacetylase 1, putative [KO:K06067] [EC:3.5.1.98]

BM_BM4804

Bm4804; uncharacterized protein [KO:K23616]

Compound

C22528

Notch intracellular domain

Reference

PMID:15288257

Authors

Hansson EM, Lendahl U, Chapman G.

Title

Notch signaling in development and disease.

Journal

Semin Cancer Biol 14:320-8 (2004)
DOI:10.1016/j.semcancer.2004.04.011

Reference

PMID:15300010

Authors

Callahan R, Egan SE.

Title

Notch signaling in mammary development and oncogenesis.

Journal

J Mammary Gland Biol Neoplasia 9:145-63 (2004)
DOI:10.1023/B:JOMG.0000037159.63644.81

Reference

PMID:15288258

Authors

Zweidler-McKay PA, Pear WS.

Title

Notch and T cell malignancy.

Journal

Semin Cancer Biol 14:329-40 (2004)
DOI:10.1016/j.semcancer.2004.04.012

Reference

PMID:15288260

Authors

Wu L, Griffin JD.

Title

Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis.

Journal

Semin Cancer Biol 14:348-56 (2004)
DOI:10.1016/j.semcancer.2004.04.014

Reference

PMID:15585829

Authors

Tsukumo S, Yasutomo K.

Title

Notch governing mature T cell differentiation.

Journal

J Immunol 173:7109-13 (2004)
DOI:10.4049/jimmunol.173.12.7109

Reference

PMID:12464310

Authors

Haltiwanger RS.

Title

Regulation of signal transduction pathways in development by glycosylation.

Journal

Curr Opin Struct Biol 12:593-8 (2002)
DOI:10.1016/S0959-440X(02)00371-8

Reference

PMID:15272268

Authors

Koo EH, Kopan R.

Title

Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

Journal

Nat Med 10 Suppl:S26-33 (2004)
DOI:10.1038/nm1065

Reference

PMID:11896183

Authors

Okano H, Imai T, Okabe M.

Title

Musashi: a translational regulator of cell fate.

Journal

J Cell Sci 115:1355-9 (2002)

Reference

PMID:12417415

Authors

Haltiwanger RS, Stanley P.

Title

Modulation of receptor signaling by glycosylation: fringe is an O-fucose-beta1,3-N-acetylglucosaminyltransferase.

Journal

Biochim Biophys Acta 1573:328-35 (2002)
DOI:10.1016/S0304-4165(02)00400-2

Reference

PMID:12015972

Authors

Das G, Reynolds-Kenneally J, Mlodzik M.

Title

The atypical cadherin Flamingo links Frizzled and Notch signaling in planar polarity establishment in the Drosophila eye.

Journal

Dev Cell 2:655-66 (2002)
DOI:10.1016/S1534-5807(02)00147-8

Reference

PMID:10028969

Authors

Cooper MT, Bray SJ.

Title

Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye.

Journal

Nature 397:526-30 (1999)
DOI:10.1038/17395

Reference

PMID:12681948

Authors

Tanigaki K, Kuroda K, Han H, Honjo T.

Title

Regulation of B cell development by Notch/RBP-J signaling.

Journal

Semin Immunol 15:113-9 (2003)
DOI:10.1016/S1044-5323(03)00008-3

Related
pathway

bmy04010

MAPK signaling pathway

KO pathway

ko04330

All links

Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG GENES (16)   
All databases (17)   

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