KEGG   PATHWAY: cal03440
Entry
cal03440                    Pathway                                
Name
Homologous recombination - Candida albicans
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
cal03440  Homologous recombination
cal03440

Other DBs
GO: 0000724
Organism
Candida albicans [GN:cal]
Gene
CAALFM_C302000WA  RAD50; MRX complex DNA-binding subunit [KO:K10866] [EC:3.6.-.-]
CAALFM_C701340WA  MRE11; MRX complex nuclease subunit [KO:K10865]
CAALFM_C603010WA  TEL1; DNA-binding protein kinase [KO:K04728] [EC:2.7.11.1]
CAALFM_C406880CA  proteasome regulatory particle lid subunit [KO:K10881]
CAALFM_C208110WA  RAD57; putative DNA-dependent ATPase [KO:K10958]
CAALFM_C200380CA  RFA1; replication factor A subunit protein [KO:K07466]
CAALFM_C207120WA  RFA2; Rfa2p [KO:K10739]
CAALFM_C109670CA  CaO19.4830; hypothetical protein [KO:K10740]
CAALFM_CR02200CA  RAD51; recombinase [KO:K04482]
CAALFM_C600510CA  RAD52; recombinase [KO:K10873]
CAALFM_C405270CA  RAD59; Rad59p [KO:K10959]
CAALFM_C113660WA  RAD54; DNA-dependent ATPase [KO:K10875] [EC:5.6.2.-]
CAALFM_C210840WA  RDH54; DNA-dependent ATPase [KO:K10877] [EC:5.6.2.-]
CAALFM_C702790CA  POL3; DNA-directed DNA polymerase delta [KO:K02327] [EC:2.7.7.7]
CAALFM_C504740CA  HYS2; DNA-directed DNA polymerase delta subunit [KO:K02328]
CAALFM_C105850WA  POL32; DNA polymerase delta subunit [KO:K03504]
CAALFM_C210570WA  SGS1; ATP-dependent DNA helicase [KO:K10901] [EC:5.6.2.4]
CAALFM_C304740CA  CaO19.5934; DNA topoisomerase 3 [KO:K03165] [EC:5.6.2.1]
CAALFM_C600540WA  CaO19.4206; hypothetical protein [KO:K08991] [EC:3.1.22.-]
CAALFM_C600770CA  CaO19.3648; hypothetical protein [KO:K10882] [EC:3.1.22.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG GENES (20)   
All databases (21)   

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