KEGG   PATHWAY: cal04141
Entry
cal04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Candida albicans
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
cal04141  Protein processing in endoplasmic reticulum
cal04141

Other DBs
GO: 0030433 0034976
Organism
Candida albicans [GN:cal]
Gene
CAALFM_C307810CA  SEC61; translocon subunit [KO:K10956]
CAALFM_C105530CA  SSH1; Ssh1p [KO:K10956]
CAALFM_CR01490CA  Arf family guanine nucleotide exchange factor [KO:K09481]
CAALFM_C306750WA  translocon subunit [KO:K07342]
CAALFM_C103340CA  SEC62; Sec63 complex subunit [KO:K12275]
CAALFM_CR04080CA  CaO19.491; protein-transporting protein [KO:K09540]
CAALFM_C305530WA  OST1; dolichyl-diphosphooligosaccharide--protein glycotransferase subunit [KO:K12666]
CAALFM_C103600WA  CaO19.3060; dolichyl-diphosphooligosaccharide-protein glycotransferase [KO:K12667]
CAALFM_C210200WA  CaO19.1761; dolichyl-diphosphooligosaccharide-protein glycotransferase [KO:K12668]
CAALFM_C306410CA  CaO19.7426; dolichyl-diphosphooligosaccharide--protein glycotransferase [KO:K12669]
CAALFM_C505020CA  CaO19.3994; dolichyl-diphosphooligosaccharide--protein glycotransferase [KO:K12669]
CAALFM_C111170WA  WBP1; dolichyl-diphosphooligosaccharide-protein glycotransferase [KO:K12670]
CAALFM_C209910CA  hypothetical protein [KO:K00730]
CAALFM_C201670CA  STT3; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit [KO:K07151] [EC:2.4.99.18]
CAALFM_C406100WA  CWH41; Cwh41p [KO:K01228] [EC:3.2.1.106]
CAALFM_CR08350WA  CaO19.6403; hypothetical protein [KO:K14001]
CAALFM_C202760WA  LHS1; Hsp70 family chaperone [KO:K09486]
CAALFM_C201120WA  KAR2; Hsp70 family ATPase [KO:K09490] [EC:3.6.4.10]
CAALFM_C208790WA  JEM1; Jem1p [KO:K09523]
CAALFM_C601460CA  CaO19.3438; hypothetical protein [KO:K14002]
CAALFM_C500220WA  ROT2; glucan 1\3-alpha-glucosidase ROT2 [KO:K05546] [EC:3.2.1.207]
CAALFM_CR00690CA  CaO19.3286; hypothetical protein [KO:K08288]
CAALFM_C404090CA  CaO19.5300; calnexin [KO:K08054]
CAALFM_C103730CA  MNS1; mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K23741] [EC:3.2.1.209]
CAALFM_C207810WA  CaO19.2200; hypothetical protein [KO:K10082]
CAALFM_CR07180WA  EMP46; Emp46p [KO:K10080]
CAALFM_C601760WA  SEC12; Sec12p [KO:K14003]
CAALFM_C602220WA  SAR1; Arf family GTPase [KO:K07953] [EC:3.6.5.-]
CAALFM_C303170WA  SEC13; GTPase-activating protein [KO:K14004]
CAALFM_C106930WA  PGA63; Pga63p [KO:K14005]
CAALFM_C302080WA  CaO19.1638; hypothetical protein [KO:K14006]
CAALFM_C701660CA  CaO19.6558; hypothetical protein [KO:K14006]
CAALFM_C405690WA  SEC23; GTPase-activating protein [KO:K14006]
CAALFM_C203410WA  CaO19.880; hypothetical protein [KO:K14007]
CAALFM_C108740CA  SEC24; COPII subunit [KO:K14007]
CAALFM_C302960CA  KRE5; Kre5p [KO:K11718] [EC:2.4.1.-]
CAALFM_C703250CA  PDI1; protein disulfide isomerase [KO:K09580] [EC:5.3.4.1]
CAALFM_C504340WA  CaO19.3920; protein disulfide isomerase [KO:K09584] [EC:5.3.4.1]
CAALFM_C301140WA  CaO19.2516; hypothetical protein [KO:K09584] [EC:5.3.4.1]
CAALFM_C209620WA  CaO19.1392; protein disulfide isomerase [KO:K13996] [EC:5.3.4.1]
CAALFM_C110040WA  ERO1; ER oxidoreductin [KO:K10976] [EC:1.8.4.-]
CAALFM_CR10020CA  CaO19.7578; hypothetical protein [KO:K10088]
CAALFM_C202410WA  CaO19.1564; hypothetical protein [KO:K14009]
CAALFM_CR10810CA  CaO19.7672; hypothetical protein [KO:K13989]
CAALFM_C502390CA  CaO19.4247; hypothetical protein [KO:K13989]
CAALFM_C101890CA  CaO19.4534; hypothetical protein [KO:K24348]
CAALFM_CR01610CA  SHP1; protein phosphatase regulator [KO:K14012]
CAALFM_C406740CA  CaO19.3135; hypothetical protein [KO:K14013]
CAALFM_C110790WA  CDC48; AAA family ATPase [KO:K13525]
CAALFM_C106110CA  NPL4; Npl4p [KO:K14015]
CAALFM_C202730WA  CaO19.5833; polyubiquitin-binding protein [KO:K14016]
CAALFM_C113480WA  HSP70; Hsp70 family chaperone [KO:K03283]
CAALFM_CR08090WA  SSB1; Hsp70 family ATPase [KO:K03283]
CAALFM_C104300CA  SSA2; Hsp70 family chaperone [KO:K03283]
CAALFM_CR04200WA  YDJ1; type I HSP40 co-chaperone [KO:K09503]
CAALFM_CR08420WA  CaO19.6408; hypothetical protein [KO:K09503]
CAALFM_C500350CA  CaO19.954; hypothetical protein [KO:K09503]
CAALFM_C704050WA  HLJ1; type I HSP40 co-chaperone [KO:K09518]
CAALFM_C702030WA  HSP90; Hsp90 family chaperone [KO:K04079]
CAALFM_C106100CA  MSI3; adenyl-nucleotide exchange factor [KO:K09485]
CAALFM_C600760WA  CaO19.3649; hypothetical protein [KO:K09562]
CAALFM_C110530WA  SNL1; Snl1p [KO:K14017]
CAALFM_C102440CA  CaO19.2933; ubiquitin-specific protease [KO:K13719] [EC:3.1.2.-]
CAALFM_C109660WA  DOA1; Doa1p [KO:K14018]
CAALFM_C201850WA  RAD23; Rad23p [KO:K10839]
CAALFM_C210670WA  CaO19.5345; hypothetical protein [KO:K04523]
CAALFM_C206490WA  CaO19.26; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
CAALFM_C304970CA  CaO19.5965; ubiquitin-ubiquitin ligase [KO:K10597] [EC:2.3.2.27]
CAALFM_C106960WA  SUI2; translation initiation factor eIF2 subunit alpha [KO:K03237]
CAALFM_C107970CA  IRE1; bifunctional endoribonuclease/protein kinase [KO:K08852] [EC:2.7.11.1 3.1.26.-]
CAALFM_C702860CA  CaO19.5175; E3 ubiquitin-protein ligase [KO:K10661] [EC:2.3.2.27]
CAALFM_C305680WA  CaO19.7347; E2 ubiquitin-conjugating protein [KO:K04554] [EC:2.3.2.23]
CAALFM_CR09340WA  CaO19.7329; E2 ubiquitin-conjugating protein [KO:K04555] [EC:2.3.2.23]
CAALFM_C503570WA  CaO19.6668; hypothetical protein [KO:K14022]
CAALFM_C600310WA  CaO19.1191; ubiquitin ligase complex subunit [KO:K14023]
CAALFM_CR06470WA  CaO19.719; E3 ubiquitin-protein ligase [KO:K10601] [EC:2.3.2.27]
CAALFM_C405250WA  CaO19.6864; hypothetical protein [KO:K09561] [EC:2.3.2.27]
CAALFM_CR09970WA  UBC4; E2 ubiquitin-conjugating protein [KO:K06689] [EC:2.3.2.23]
CAALFM_C302450WA  HRT1; SCF ubiquitin ligase complex subunit [KO:K03868] [EC:2.3.2.32]
CAALFM_C301700WA  CDC53; cullin [KO:K03347]
CAALFM_C107410CA  SKP1; SCF ubiquitin ligase subunit [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
cal00510  N-Glycan biosynthesis
cal03050  Proteasome
cal03060  Protein export
KO pathway
ko04141   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (81)   
   KEGG GENES (81)   
All databases (82)   

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