KEGG   PATHWAY: cal04146
Entry
cal04146                    Pathway                                
Name
Peroxisome - Candida albicans
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
cal04146  Peroxisome
cal04146

Other DBs
GO: 0005777
Organism
Candida albicans [GN:cal]
Gene
CAALFM_C107420CA  PEX3; Pex3p [KO:K13336]
CAALFM_CR08600CA  PEX19; Pex19p [KO:K13337]
CAALFM_C702490WA  PEX1; AAA family ATPase peroxin 1 [KO:K13338]
CAALFM_C205440WA  PEX6; AAA family ATPase peroxin 6 [KO:K13339]
CAALFM_C600880WA  PEX7; Pex7p [KO:K13341]
CAALFM_C400150CA  PEX5; Pex5p [KO:K13342]
CAALFM_CR04930WA  PEX14; Pex14p [KO:K13343]
CAALFM_CR08870WA  PEX13; peroxin [KO:K13344]
CAALFM_C201150WA  PEX12; ubiquitin-protein ligase peroxin 12 [KO:K13345]
CAALFM_C400320CA  CaO19.5660; ubiquitin-protein ligase peroxin 10 [KO:K13346]
CAALFM_C205150WA  PEX2; ubiquitin-protein ligase peroxin 2 [KO:K06664]
CAALFM_C206430CA  CaO19.21; ethanol metabolism protein [KO:K13348]
CAALFM_C206440CA  CaO19.22; hypothetical protein [KO:K13348]
CAALFM_C703260CA  CaO19.5129; hypothetical protein [KO:K13350]
CAALFM_C604310WA  PEX11; Pex11p [KO:K13352]
CAALFM_C304630WA  CaO19.5921; hypothetical protein [KO:K13354]
CAALFM_CR09190CA  CaO19.7316; hypothetical protein [KO:K00477] [EC:1.14.11.18]
CAALFM_C301960CA  POX1-3; acyl-CoA oxidase [KO:K00232] [EC:1.3.3.6]
CAALFM_C301930WA  PXP2; Pxp2p [KO:K00232] [EC:1.3.3.6]
CAALFM_C603560WA  POX1; Pox1p [KO:K00232] [EC:1.3.3.6]
CAALFM_C200780WA  POT1-2; Pot1-2p [KO:K07513] [EC:2.3.1.16]
CAALFM_CR00150CA  POT1; acetyl-CoA C-acyltransferase [KO:K07513] [EC:2.3.1.16]
CAALFM_C301460CA  FOX3; Fox3p [KO:K07513] [EC:2.3.1.16]
CAALFM_C400830WA  SPS20; Sps20p [KO:K13237] [EC:1.3.1.124]
CAALFM_C102270CA  CaO19.3684; hypothetical protein [KO:K13237] [EC:1.3.1.124]
CAALFM_C306730WA  CaO19.6830; hypothetical protein [KO:K12663] [EC:5.3.3.21]
CAALFM_CR00330CA  PXA1; ATP-binding cassette long-chain fatty acid transporter [KO:K15628] [EC:7.6.2.4]
CAALFM_C112100CA  PXA2; ATP-binding cassette long-chain fatty acid transporter [KO:K15628] [EC:7.6.2.4]
CAALFM_CR10160WA  FAA4; long-chain fatty acid-CoA ligase [KO:K01897] [EC:6.2.1.3]
CAALFM_C704180WA  FAA2-3; Faa2-3p [KO:K01897] [EC:6.2.1.3]
CAALFM_C305980CA  FAA2; Faa2p [KO:K01897] [EC:6.2.1.3]
CAALFM_C206070WA  FAA2-1; Faa2-1p [KO:K01897] [EC:6.2.1.3]
CAALFM_C302810CA  FAA21; medium-chain fatty acid-CoA ligase [KO:K01897] [EC:6.2.1.3]
CAALFM_CR08690CA  ECI1; dodecenoyl-CoA isomerase [KO:K13239] [EC:5.3.3.8]
CAALFM_CR08670CA  CaO19.6443; hypothetical protein [KO:K13239] [EC:5.3.3.8]
CAALFM_C602410WA  CaO19.3482; NAD(+) diphosphatase [KO:K03426] [EC:3.6.1.22]
CAALFM_C101740WA  CTN1; carnitine O-acetyltransferase [KO:K00624] [EC:2.3.1.7]
CAALFM_C402020WA  CAT2; carnitine O-acetyltransferase [KO:K00624] [EC:2.3.1.7]
CAALFM_C304000CA  CTN3; carnitine O-acetyltransferase [KO:K00624] [EC:2.3.1.7]
CAALFM_C109460WA  ERG12; mevalonate kinase [KO:K00869] [EC:2.7.1.36]
CAALFM_C103670CA  DAO1; Dao1p [KO:K00273] [EC:1.4.3.3]
CAALFM_C500450CA  IFG3; Ifg3p [KO:K00273] [EC:1.4.3.3]
CAALFM_C403380CA  DAO2; Dao2p [KO:K00273] [EC:1.4.3.3]
CAALFM_C205890CA  IDP1; isocitrate dehydrogenase (NADP(+)) [KO:K00031] [EC:1.1.1.42]
CAALFM_CR02360WA  IDP2; isocitrate dehydrogenase (NADP(+)) [KO:K00031] [EC:1.1.1.42]
CAALFM_C106810WA  CAT1; catalase A [KO:K03781] [EC:1.11.1.6]
CAALFM_C105410CA  TRP99; Trp99p [KO:K11187] [EC:1.11.1.24]
CAALFM_C402320CA  SOD1; superoxide dismutase [KO:K04565] [EC:1.15.1.1]
CAALFM_C101520CA  SOD2; superoxide dismutase [KO:K04564] [EC:1.15.1.1]
CAALFM_C504530WA  CaO19.3938; mitochondrial 37S ribosomal protein RSM26 [KO:K04564] [EC:1.15.1.1]
CAALFM_C301850WA  CaO19.1662; mitochondrial 37S ribosomal protein MRP1 [KO:K04564] [EC:1.15.1.1]
CAALFM_C700110WA  SOD3; Sod3p [KO:K04564] [EC:1.15.1.1]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
cal00071  Fatty acid degradation
cal00230  Purine metabolism
cal00564  Glycerophospholipid metabolism
cal00565  Ether lipid metabolism
cal00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (52)   
   KEGG GENES (52)   
All databases (53)   

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