KEGG   PATHWAY: cho03013
Entry
cho03013                    Pathway                                
Name
Nucleocytoplasmic transport - Cryptosporidium hominis
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
cho03013  Nucleocytoplasmic transport
cho03013

Other DBs
GO: 0050658
Organism
Cryptosporidium hominis [GN:cho]
Gene
Chro.70044  hypothetical protein [KO:K18723]
Chro.80546  DEAD-box RNA helicase [KO:K18655] [EC:5.6.2.7]
Chro.60529  mRNA export protein [KO:K14298]
Chro.80185  hypothetical protein [KO:K14297]
Chro.80472  hypothetical protein [KO:K14004]
Chro.20379  hypothetical protein [KO:K14306]
Chro.30358  hypothetical protein [KO:K20724]
Chro.80378  importin alpha [KO:K15042]
Chro.70341  importin-beta2 [KO:K14293]
Chro.80396  karyopherin (importin) beta 2 [KO:K18752]
Chro.70365  karyopherin beta [KO:K20222]
Chro.30225  CG32297-PA [KO:K13151]
Chro.30346  exportin 1 (chromosome region maintenance protein 1) (caffeine resistance protein 2) [KO:K14290]
Chro.30213  cellular apoptosis susceptibility gene product [KO:K18423]
Chro.70197  hypothetical protein [KO:K18460]
Chro.70035  GTP-binding nuclear protein ran/tc4 [KO:K07936]
Chro.60459  elongation factor 1-alpha (EF-1-ALPHA) [KO:K03231]
Chro.60207  nuclear cap-binding protein [KO:K12883]
Chro.30166  Upf1p-interacting protein; Nmd3p [KO:K07562]
Chro.70440  eukaryotic initiation factor 4A-3 (eIF4A-3) (eIF-4A-3) [KO:K13025] [EC:5.6.2.7]
Chro.80448  helicase [KO:K12812] [EC:5.6.2.7]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
cho03015  mRNA surveillance pathway
KO pathway
ko03013   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG GENES (21)   
All databases (22)   

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