KEGG   PATHWAY: cho03420
Entry
cho03420                    Pathway                                
Name
Nucleotide excision repair - Cryptosporidium hominis
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
cho03420  Nucleotide excision repair
cho03420

Other DBs
GO: 0006289
Organism
Cryptosporidium hominis [GN:cho]
Gene
Chro.80373  helicase [KO:K03657] [EC:5.6.2.4]
Chro.80112  ring-box 1; RING box protein 1; regulator of cullins 1; RING finger protein; ZYP protein [KO:K03868] [EC:2.3.2.32]
Chro.10318  ENSANGP00000003051 [KO:K10610]
Chro.60190  Rad4-related protein [KO:K10838]
Chro.70524  RAD 23B protein [KO:K10839]
Chro.50413  RAD26-like dna repair and recombination protein [KO:K10841]
Chro.30301  DNA-directed RNA polymerase II largest chain [KO:K03006] [EC:2.7.7.6]
Chro.70415  DNA-directed RNA polymerase II second largest chain [KO:K03010] [EC:2.7.7.6]
Chro.10306  conjugation stage-specific protein [KO:K03011]
Chro.20109  DNA-directed RNA polymerase 2 [KO:K03013]
Chro.70529  DNA-directed RNA polymerase IIa [KO:K03014]
Chro.10257  RNA polymerase subunit 8c [KO:K03016]
Chro.30221  DNA-directed RNA polymerase 2 subunit [KO:K03017]
Chro.70056  cyclin-dependent kinase-related kinase [KO:K02202] [EC:2.7.11.22 2.7.11.23]
Chro.10372  transcription/repair factor TFIIH subunit Tfb3 [KO:K10842]
Chro.10373  hypothetical protein [KO:K06634]
Chro.80227  hypothetical protein [KO:K10843] [EC:5.6.2.4]
Chro.70101  DNA repair protein-related [KO:K10844] [EC:5.6.2.3]
Chro.60062  hypothetical protein [KO:K03141]
Chro.30353  hypothetical protein [KO:K03142]
Chro.60580  transcription factor [KO:K03143]
Chro.20223  hypothetical protein [KO:K03144]
Chro.40058  RAD2 [KO:K10846]
Chro.40079  hypothetical protein [KO:K10847]
Chro.70509  replication protein A 70kDa [KO:K07466]
Chro.20435  replication protein A2; CpRPA2 [KO:K10739]
Chro.40338  UV endonuclease; Rad1p [KO:K10848] [EC:3.1.-.-]
Chro.40337  repair endonuclease (gb [KO:K10848] [EC:3.1.-.-]
Chro.60302  excision repair cross-complementing rodent repair deficiency,complementation group 1 [KO:K10849]
Chro.60506  DNA polymerase family B subunit [KO:K02327] [EC:2.7.7.7]
Chro.80190  hypothetical protein [KO:K02328]
Chro.80536  hypothetical protein [KO:K03505]
Chro.80147  DNA polymerase epsilon catalytic subunit -related [KO:K02324] [EC:2.7.7.7]
Chro.20265  hypothetical protein [KO:K02325] [EC:2.7.7.7]
Chro.30392  proliferating cell nuclear antigen [KO:K04802]
Chro.80254  proliferating cell nuclear antigen (PCNA) (cyclin) [KO:K04802]
Chro.80076  replication factor C subunit 1 [KO:K10754]
Chro.30175  replication factor c subunit 4 [KO:K10755]
Chro.80342  replication factor C subunit [KO:K10755]
Chro.30359  replication factor C3 [KO:K10756]
Chro.20333  replication factor C subunit 5 [KO:K10756]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
cho03020  RNA polymerase
cho04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (41)   
   KEGG GENES (41)   
All databases (42)   

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