KEGG   PATHWAY: egr00480
Entry
egr00480                    Pathway                                
Name
Glutathione metabolism - Eucalyptus grandis (rose gum)
Class
Metabolism; Metabolism of other amino acids
Pathway map
egr00480  Glutathione metabolism
egr00480

Module
egr_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:egr00480]
Other DBs
GO: 0006749
Organism
Eucalyptus grandis (rose gum) [GN:egr]
Gene
104429119  glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
104437272  gamma-glutamylcyclotransferase 2-1 [KO:K22596] [EC:4.3.2.9]
104450944  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
104418662  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
104441749  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
104415517  LOW QUALITY PROTEIN: glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
104415525  LOW QUALITY PROTEIN: glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
104436087  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
104441733  puromycin-sensitive aminopeptidase isoform X1 [KO:K01256] [EC:3.4.11.2]
104429667  glutathione S-transferase U19 [KO:K00799] [EC:2.5.1.18]
104436010  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
104435964  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
104435983  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
104435974  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
104436032  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
104433630  glutathione S-transferase U10 [KO:K00799] [EC:2.5.1.18]
104419713  glutathione S-transferase U9 [KO:K00799] [EC:2.5.1.18]
104419722  glutathione S-transferase U9 [KO:K00799] [EC:2.5.1.18]
104432947  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
104419705  glutathione S-transferase U9 [KO:K00799] [EC:2.5.1.18]
104434340  glutathione S-transferase U10 [KO:K00799] [EC:2.5.1.18]
104433632  glutathione S-transferase U10 [KO:K00799] [EC:2.5.1.18]
104433115  glutathione S-transferase U19 [KO:K00799] [EC:2.5.1.18]
104433117  glutathione S-transferase U19 [KO:K00799] [EC:2.5.1.18]
104433118  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104433119  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
104454029  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104454030  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
104425815  LOW QUALITY PROTEIN: glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
108960636  glutathione S-transferase PARB-like [KO:K00799] [EC:2.5.1.18]
104414194  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104417039  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
104426520  LOW QUALITY PROTEIN: glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
104426521  glutathione S-transferase L3 isoform X2 [KO:K00799] [EC:2.5.1.18]
104416097  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
104456097  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
104456096  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
104456066  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
104441761  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
104415131  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104448643  glutathione S-transferase U25-like [KO:K00799] [EC:2.5.1.18]
104414197  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104414195  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
104456806  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104456799  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104456801  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104456797  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104456805  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104456802  glutathione S-transferase isoform X5 [KO:K00799] [EC:2.5.1.18]
104456798  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104448642  LOW QUALITY PROTEIN: glutathione S-transferase U25 [KO:K00799] [EC:2.5.1.18]
104450033  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104448004  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
104449775  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
108953811  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104440614  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
104449769  glutathione S-transferase F12 [KO:K00799] [EC:2.5.1.18]
104448645  glutathione S-transferase U19 isoform X1 [KO:K00799] [EC:2.5.1.18]
104448647  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104414196  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104448653  glutathione S-transferase U25 [KO:K00799] [EC:2.5.1.18]
104425060  LOW QUALITY PROTEIN: glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
104425057  LOW QUALITY PROTEIN: glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
104425058  glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
104425062  glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
104425061  glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
104425063  LOW QUALITY PROTEIN: glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
104425056  glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
104427318  glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
104430794  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
104430006  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104430041  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104421831  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
104425384  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
104425386  LOW QUALITY PROTEIN: glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
104425388  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
104425385  LOW QUALITY PROTEIN: glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
104425387  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
104426419  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104426418  glutathione S-transferase U8 [KO:K00799] [EC:2.5.1.18]
104429546  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
104426417  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104426412  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104426416  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104426411  LOW QUALITY PROTEIN: glutathione S-transferase U8 [KO:K00799] [EC:2.5.1.18]
104426738  glutathione S-transferase F13 [KO:K00799] [EC:2.5.1.18]
104427977  LOW QUALITY PROTEIN: glutathione S-transferase F13 [KO:K00799] [EC:2.5.1.18]
104416439  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
120287799  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
120287840  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
104434341  glutathione S-transferase U9-like [KO:K00799] [EC:2.5.1.18]
104434999  glutathione S-transferase U19 [KO:K00799] [EC:2.5.1.18]
104440613  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
104448002  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
120294872  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
120294931  glutathione S-transferase U19-like isoform X1 [KO:K00799] [EC:2.5.1.18]
104422157  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
104454151  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
104454260  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
104414377  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
104426615  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
104449757  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
104422622  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
104443108  6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
104419470  6-phosphogluconate dehydrogenase, decarboxylating 1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
104415659  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
104456888  LOW QUALITY PROTEIN: inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
104456597  glucose-6-phosphate 1-dehydrogenase, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
104424650  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
104419171  glucose-6-phosphate 1-dehydrogenase 6, cytoplasmic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
104445716  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
104437561  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
104441753  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
104441754  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
104443806  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
104457021  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
104443800  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
104453606  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
104437941  spermine synthase isoform X1 [KO:K00797] [EC:2.5.1.16]
104418481  spermidine synthase 1 isoform X1 [KO:K00797] [EC:2.5.1.16]
104438918  LOW QUALITY PROTEIN: spermidine synthase 2 [KO:K00797] [EC:2.5.1.16]
104414237  LOW QUALITY PROTEIN: spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
104435850  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
104432832  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
104437032  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
104439814  L-ascorbate peroxidase 3 isoform X1 [KO:K00434] [EC:1.11.1.11]
104418937  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
104421699  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
104450927  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
104415850  ribonucleoside-diphosphate reductase large subunit isoform X2 [KO:K10807] [EC:1.17.4.1]
104424921  ribonucleoside-diphosphate reductase small chain A [KO:K10808] [EC:1.17.4.1]
104419138  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
PMID:12675513
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
PMID:18482986
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
PMID:14583094
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
PMID:11157967
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
PMID:15610825
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
PMID:12049631
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
PMID:12750367
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
PMID:12967709
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
PMID:12121990
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
PMID:15537651
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
PMID:12751784
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
PMID:18395526
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
PMID:11150302
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
PMID:12949079
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
PMID:12446213
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
PMID:10713147
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
PMID:17922848
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
PMID:12466271
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
PMID:14982633
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
egr00220  Arginine biosynthesis
egr00250  Alanine, aspartate and glutamate metabolism
egr00270  Cysteine and methionine metabolism
egr00430  Taurine and hypotaurine metabolism
egr00460  Cyanoamino acid metabolism
KO pathway
ko00480   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (132)   
   KEGG GENES (132)   
All databases (133)   

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