KEGG   PATHWAY: egr03008
Entry
egr03008                    Pathway                                
Name
Ribosome biogenesis in eukaryotes - Eucalyptus grandis (rose gum)
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
Pathway map
egr03008  Ribosome biogenesis in eukaryotes
egr03008

Organism
Eucalyptus grandis (rose gum) [GN:egr]
Gene
104441973  putative casein kinase II subunit beta-4 [KO:K03115]
104444482  putative casein kinase II subunit beta-4 [KO:K03115]
104457388  casein kinase II subunit alpha-2 [KO:K03097] [EC:2.7.11.1]
104447821  casein kinase II subunit alpha-2 [KO:K03097] [EC:2.7.11.1]
104418449  casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
104419742  nucleolar protein 6 [KO:K14544]
104420707  uncharacterized protein LOC104420707 [KO:K14545]
104436824  uncharacterized protein LOC104436824 isoform X1 [KO:K14546]
104419474  WD repeat-containing protein 43 isoform X1 [KO:K14546]
104449250  WD repeat-containing protein PCN [KO:K14548]
104426713  LOW QUALITY PROTEIN: protein SLOW WALKER 1 [KO:K14549]
104449943  uncharacterized protein At3g06530 [KO:K14550]
104437410  WD repeat-containing protein 75 [KO:K14552]
104426617  U3 small nucleolar RNA-associated protein 18 homolog [KO:K14553]
104437297  LOW QUALITY PROTEIN: U3 small nucleolar RNA-associated protein 21 homolog [KO:K14554]
120291822  LOW QUALITY PROTEIN: WD repeat-containing protein 36-like [KO:K14554]
104426931  transducin beta-like protein 3 [KO:K14555]
104425945  LOW QUALITY PROTEIN: WD repeat-containing protein 3 [KO:K14556]
120291065  LOW QUALITY PROTEIN: WD repeat-containing protein 3-like [KO:K14556]
104441419  U3 small nucleolar RNA-associated protein 6 homolog [KO:K14557]
104423157  periodic tryptophan protein 2 [KO:K14558]
104426254  U3 small nucleolar ribonucleoprotein protein MPP10 [KO:K14559]
104422052  LOW QUALITY PROTEIN: U3 small nucleolar ribonucleoprotein protein IMP3 [KO:K14560]
104454557  U3 small nucleolar ribonucleoprotein protein IMP4 [KO:K14561]
104424439  rRNA 2'-O-methyltransferase fibrillarin 2 [KO:K14563] [EC:2.1.1.-]
104426176  LOW QUALITY PROTEIN: nucleolar protein 56 [KO:K14564]
120290020  LOW QUALITY PROTEIN: nucleolar protein 56-like [KO:K14564]
104415490  probable nucleolar protein 5-2 [KO:K14565]
104438520  NHP2-like protein 1 [KO:K12845]
104436675  NHP2-like protein 1 [KO:K12845]
120291690  NHP2-like protein 1 [KO:K12845]
104421194  H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129]
104426086  H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129]
104425269  putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 [KO:K11128]
104433665  H/ACA ribonucleoprotein complex subunit 3-like protein [KO:K11130]
104443390  rRNA-processing protein FCF1 homolog [KO:K14566]
104426773  LOW QUALITY PROTEIN: uncharacterized protein C57A7.06 [KO:K14567]
104447254  ribosomal RNA small subunit methyltransferase NEP1 [KO:K14568] [EC:2.1.1.260]
104440803  ribosomal RNA small subunit methyltransferase NEP1 [KO:K14568] [EC:2.1.1.260]
104451912  ribosome biogenesis protein BMS1 homolog isoform X1 [KO:K14569]
104415840  RNA cytidine acetyltransferase 1 isoform X1 [KO:K14521] [EC:2.3.1.-]
104433948  probable RNA 3'-terminal phosphate cyclase-like protein [KO:K11108]
104450307  uncharacterized protein LOC104450307 [KO:K01164] [EC:3.1.26.5]
104440775  LOW QUALITY PROTEIN: ribonuclease P protein subunit p29 [KO:K03538] [EC:3.1.26.5]
104424578  LOW QUALITY PROTEIN: probable ribonuclease P/MRP protein subunit POP5 [KO:K03537] [EC:3.1.26.5]
104430757  probable ribonuclease P/MRP protein subunit POP5 [KO:K03537] [EC:3.1.26.5]
104448470  uncharacterized protein LOC104448470 isoform X1 [KO:K03539] [EC:3.1.26.5]
104449643  small RNA degrading nuclease 5 isoform X1 [KO:K14570] [EC:3.1.-.-]
104418506  LOW QUALITY PROTEIN: small RNA degrading nuclease 3 [KO:K14570] [EC:3.1.-.-]
104433914  oligoribonuclease [KO:K13288] [EC:3.1.-.-]
104448827  5'-3' exoribonuclease 3 isoform X1 [KO:K12619] [EC:3.1.13.-]
104445412  nucleolar GTP-binding protein 1 isoform X1 [KO:K06943]
104450666  nucleolar GTP-binding protein 1 [KO:K06943]
120291186  LOW QUALITY PROTEIN: nucleolar GTP-binding protein 1-like [KO:K06943]
104450142  nuclear/nucleolar GTPase 2 [KO:K14537]
104426881  guanine nucleotide-binding protein-like NSN1 [KO:K14538]
104415090  LOW QUALITY PROTEIN: cell division control protein 48 homolog C [KO:K14571]
104423002  LOW QUALITY PROTEIN: midasin [KO:K14572]
104418859  RNA-binding protein 28 [KO:K14573]
104443793  RNA-binding protein NOB1 [KO:K11883]
104438497  GTP-binding nuclear protein Ran1A isoform X1 [KO:K07936]
104436643  LOW QUALITY PROTEIN: GTP-binding nuclear protein Ran-3 [KO:K07936]
104444262  GTP-binding nuclear protein Ran1A-like [KO:K07936]
104431007  GTP-binding nuclear protein Ran-3-like [KO:K07936]
120291236  GTP-binding nuclear protein Ran1A-like [KO:K07936]
104439167  GTP-binding nuclear protein Ran1A [KO:K07936]
104450369  protein EXPORTIN 1A [KO:K14290]
104419881  60S ribosomal export protein NMD3 [KO:K07562]
104422858  eukaryotic translation initiation factor 6-2 [KO:K03264]
104454063  LOW QUALITY PROTEIN: ribosome maturation protein SBDS [KO:K14574]
104433204  elongation factor-like GTPase 1 [KO:K14536] [EC:3.6.5.-]
104421360  GTPase LSG1-2 [KO:K14539] [EC:3.6.1.-]
104421686  adenylate kinase isoenzyme 6 homolog [KO:K18532] [EC:2.7.4.3]
104444399  serine/threonine-protein kinase RIO1 [KO:K07178] [EC:2.7.11.1]
104456154  serine/threonine-protein kinase rio2 [KO:K07179] [EC:2.7.11.1]
9845765  EucgrC_r008; 16S ribosomal RNA [KO:K01979]
120293060  18S ribosomal RNA [KO:K01979]
9845767  EucgrC_r007; 23S ribosomal RNA [KO:K01982]
120293066  28S ribosomal RNA [KO:K01982]
120291005  28S ribosomal RNA [KO:K01982]
9829617  rrn5; 5S ribosomal RNA [KO:K01981]
9845768  EucgrC_r005; 5S ribosomal RNA [KO:K01981]
120289072  small nucleolar RNA U3 [KO:K14483]
Reference
PMID:20174677
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
DOI:10.1039/b919670f
Reference
PMID:17515605
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
DOI:10.1128/MCB.00380-07
Reference
PMID:19850913
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
DOI:10.1261/rna.1792109
Reference
PMID:15120992
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
DOI:10.1016/j.yexcr.2004.03.016
Reference
PMID:19879902
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
DOI:10.1016/j.bbamcr.2009.10.009
Related
pathway
egr03010  Ribosome
KO pathway
ko03008   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (83)   
   KEGG GENES (83)   
All databases (84)   

Download RDF
DBGET integrated database retrieval system