KEGG   PATHWAY: egr03410
Entry
egr03410                    Pathway                                
Name
Base excision repair - Eucalyptus grandis (rose gum)
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
Pathway map
egr03410  Base excision repair
egr03410

Other DBs
GO: 0006284 0006285 0006286 0006287 0006288
Organism
Eucalyptus grandis (rose gum) [GN:egr]
Gene
104450523  N-glycosylase/DNA lyase OGG1 [KO:K03660] [EC:3.2.2.- 4.2.99.18]
104456249  endonuclease III homolog 1, chloroplastic isoform X1 [KO:K10773] [EC:3.2.2.- 4.2.99.18]
104426296  putative DNA glycosylase At3g47830 [KO:K10773] [EC:3.2.2.- 4.2.99.18]
104421578  LOW QUALITY PROTEIN: uracil-DNA glycosylase, mitochondrial [KO:K03648] [EC:3.2.2.27]
104456451  adenine DNA glycosylase [KO:K03575] [EC:3.2.2.31]
104425501  DNA-3-methyladenine glycosylase [KO:K03652] [EC:3.2.2.21]
104428337  methyl-CpG-binding domain protein 4-like protein isoform X1 [KO:K10801] [EC:3.2.2.-]
104448543  polynucleotide 3'-phosphatase ZDP [KO:K08073] [EC:3.1.3.32 2.7.1.78]
120294912  polynucleotide 3'-phosphatase ZDP-like [KO:K08073] [EC:3.1.3.32 2.7.1.78]
104441126  tyrosyl-DNA phosphodiesterase 1 [KO:K10862] [EC:3.1.4.-]
104432925  DNA polymerase lambda isoform X1 [KO:K03512] [EC:2.7.7.7 4.2.99.-]
104426598  poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
104421296  protein ADP-ribosyltransferase PARP3 [KO:K10798] [EC:2.4.2.30]
104456747  poly [ADP-ribose] polymerase 2 [KO:K10798] [EC:2.4.2.30]
104454843  poly(ADP-ribose) glycohydrolase 1 isoform X1 [KO:K07759] [EC:3.2.1.143]
104423355  LOW QUALITY PROTEIN: transcription factor bHLH140 [KO:K10863] [EC:3.6.1.70 3.6.1.71 3.6.1.72]
104449854  DNA-repair protein XRCC1 [KO:K10803]
104418096  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
104425494  DNA polymerase delta small subunit isoform X1 [KO:K02328]
104448554  uncharacterized protein LOC104448554 [KO:K03504]
104451548  uncharacterized protein LOC104451548 [KO:K03504]
104418231  LOW QUALITY PROTEIN: DNA polymerase delta subunit 4 [KO:K03505]
104434005  DNA polymerase epsilon catalytic subunit A [KO:K02324] [EC:2.7.7.7]
104456397  LOW QUALITY PROTEIN: DNA polymerase epsilon subunit B [KO:K02325] [EC:2.7.7.7]
104421306  DNA polymerase epsilon subunit D [KO:K02326] [EC:2.7.7.7]
104422418  proliferating cell nuclear antigen [KO:K04802]
104421373  replication factor C subunit 1 [KO:K10754]
104450918  replication factor C subunit 2 [KO:K10755]
104441792  replication factor C subunit 2 [KO:K10755]
104443285  replication factor C subunit 3 isoform X2 [KO:K10756]
104417305  uncharacterized protein LOC104417305 [KO:K10756]
104450925  replication factor C subunit 3 [KO:K10756]
104426392  LOW QUALITY PROTEIN: flap endonuclease 1 [KO:K04799] [EC:3.1.-.-]
104434158  LOW QUALITY PROTEIN: flap endonuclease 1 [KO:K04799] [EC:3.1.-.-]
104426401  flap endonuclease 1 [KO:K04799] [EC:3.1.-.-]
104435034  flap endonuclease 1 isoform X1 [KO:K04799] [EC:3.1.-.-]
104456906  flap endonuclease 1 [KO:K04799] [EC:3.1.-.-]
104426474  flap endonuclease 1-like [KO:K04799] [EC:3.1.-.-]
104434754  flap endonuclease 1-like [KO:K04799] [EC:3.1.-.-]
120286196  flap endonuclease 1-like [KO:K04799] [EC:3.1.-.-]
104430191  flap endonuclease 1-like [KO:K04799] [EC:3.1.-.-]
104421226  DNA ligase 1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
104450585  LOW QUALITY PROTEIN: formamidopyrimidine-DNA glycosylase [KO:K10563] [EC:3.2.2.23 4.2.99.18]
104448760  probable DNA-3-methyladenine glycosylase 2 [KO:K01247] [EC:3.2.2.21]
104433350  DNA-3-methyladenine glycosylase [KO:K01246] [EC:3.2.2.20]
104436088  uncharacterized protein LOC104436088 [KO:K01246] [EC:3.2.2.20]
104445842  uncharacterized protein LOC104445842 [KO:K01246] [EC:3.2.2.20]
104448734  probable GMP synthase [glutamine-hydrolyzing] [KO:K01246] [EC:3.2.2.20]
104448688  uncharacterized protein LOC104448688 [KO:K01246] [EC:3.2.2.20]
104450624  probable GMP synthase [glutamine-hydrolyzing] [KO:K01246] [EC:3.2.2.20]
104448335  DNA polymerase I A, chloroplastic/mitochondrial [KO:K02335] [EC:2.7.7.7]
Reference
PMID:17893748
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
PMID:17337257
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
DOI:10.1016/j.dnarep.2007.01.009
Reference
PMID:21665970
  Authors
Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
  Title
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
  Journal
J Bacteriol 193:4495-508 (2011)
DOI:10.1128/JB.00233-11
Reference
PMID:11436317
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease]
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
ko03410   

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Genome (1)   
   KEGG GENOME (1)   
Gene (51)   
   KEGG GENES (51)   
All databases (52)   

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