KEGG   PATHWAY: egr04141
Entry
egr04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Eucalyptus grandis (rose gum)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
egr04141  Protein processing in endoplasmic reticulum
egr04141

Other DBs
GO: 0030433 0034976
Organism
Eucalyptus grandis (rose gum) [GN:egr]
Gene
104437456  preprotein translocase subunit SCY1, chloroplastic [KO:K10956]
104450102  protein transport protein Sec61 subunit alpha [KO:K10956]
104448553  protein transport protein Sec61 subunit alpha [KO:K10956]
104447337  protein transport protein Sec61 subunit alpha [KO:K10956]
104456011  protein transport protein Sec61 subunit beta [KO:K09481]
104442277  protein transport protein Sec61 subunit beta [KO:K09481]
104421678  protein transport protein Sec61 subunit beta [KO:K09481]
104416847  protein transport protein Sec61 subunit gamma [KO:K07342]
104426155  protein transport protein Sec61 subunit gamma [KO:K07342]
104421511  uncharacterized protein LOC104421511 isoform X1 [KO:K12275]
120294092  dnaJ protein ERDJ2A-like [KO:K09540]
104448949  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A [KO:K12666]
104454222  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B [KO:K12666]
104426567  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
104456463  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
104453501  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
104425874  LOW QUALITY PROTEIN: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
104436577  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
104445743  probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3B [KO:K19478]
104435906  oligosaccharyltransferase complex subunit OSTC [KO:K26501]
104436484  transmembrane protein 258 [KO:K26502]
104438325  transmembrane protein 258-like [KO:K26502]
120291217  transmembrane protein 258-like [KO:K26502]
104433660  LOW QUALITY PROTEIN: mannosyl-oligosaccharide glucosidase GCS1 [KO:K01228] [EC:3.2.1.106]
120290836  LOW QUALITY PROTEIN: mannosyl-oligosaccharide glucosidase GCS1 [KO:K01228] [EC:3.2.1.106]
104436750  heat shock 70 kDa protein 17 [KO:K09486]
104444086  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
104429945  LOW QUALITY PROTEIN: heat shock 70 kDa protein BIP1 [KO:K09490] [EC:3.6.4.10]
104417707  LOW QUALITY PROTEIN: luminal-binding protein 5 [KO:K09490] [EC:3.6.4.10]
104426807  dnaJ protein ERDJ3B [KO:K09517]
104426550  dnaJ protein P58IPK homolog isoform X1 [KO:K09523]
104434674  heat shock protein 90-6, mitochondrial [KO:K09487]
104433348  heat shock protein 90-5, chloroplastic [KO:K09487]
104456658  endoplasmin homolog [KO:K09487]
104418062  probable glucan 1,3-alpha-glucosidase [KO:K05546] [EC:3.2.1.207]
104433757  glucosidase 2 subunit beta [KO:K08288]
104422269  LOW QUALITY PROTEIN: glucosidase 2 subunit beta [KO:K08288]
104433743  calnexin homolog [KO:K08054]
104433742  calnexin homolog [KO:K08054]
104447947  calreticulin-3 [KO:K08057]
104426918  calreticulin-3 [KO:K08057]
104428253  calreticulin [KO:K08057]
104414665  calreticulin [KO:K08057]
104450686  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 [KO:K01230] [EC:3.2.1.113]
104440790  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3 [KO:K23741] [EC:3.2.1.209]
104423533  LOW QUALITY PROTEIN: SEC12-like protein 1 [KO:K14003]
104453711  SEC12-like protein 2 [KO:K14003]
104454125  LOW QUALITY PROTEIN: SEC12-like protein 1 [KO:K14003]
104451348  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
104452002  GTP-binding protein SAR1A isoform X1 [KO:K07953] [EC:3.6.5.-]
104452018  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
104452134  GTP-binding protein SAR1B isoform X1 [KO:K07953] [EC:3.6.5.-]
104450140  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
104441935  LOW QUALITY PROTEIN: GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
104441759  LOW QUALITY PROTEIN: GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
104449392  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
104452029  LOW QUALITY PROTEIN: GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
104456708  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
104430277  LOW QUALITY PROTEIN: GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
104415226  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
104426816  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
120295256  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
104424675  protein transport protein SEC13 homolog B [KO:K14004]
104422580  protein transport protein SEC13 homolog B [KO:K14004]
104454584  protein transport protein SEC31 homolog B isoform X1 [KO:K14005]
104414581  LOW QUALITY PROTEIN: protein transport protein Sec23A [KO:K14006]
104441302  LOW QUALITY PROTEIN: protein transport protein SEC23 [KO:K14006]
104418457  protein transport protein SEC23 [KO:K14006]
104432958  protein transport protein Sec24-like At4g32640 [KO:K14007]
104440894  protein transport protein Sec24-like At3g07100 [KO:K14007]
104419973  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
104418312  alpha-mannosidase I MNS5 isoform X1 [KO:K10084]
104456139  alpha-mannosidase I MNS4 [KO:K10085]
104432871  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
104437343  protein disulfide-isomerase 5-2 [KO:K09580] [EC:5.3.4.1]
104450929  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
104449878  protein disulfide isomerase-like 1-6 isoform X1 [KO:K09580] [EC:5.3.4.1]
104426806  protein disulfide-isomerase like 2-1 [KO:K09584] [EC:5.3.4.1]
104424708  protein disulfide isomerase-like 2-3 isoform X1 [KO:K09584] [EC:5.3.4.1]
104450030  endoplasmic reticulum oxidoreductin-1 [KO:K10950] [EC:1.8.4.-]
104440773  endoplasmic reticulum oxidoreductin-1 [KO:K10950] [EC:1.8.4.-]
104436177  protein OS-9 homolog [KO:K10088]
104418913  translocon-associated protein subunit alpha [KO:K13249]
104419110  translocon-associated protein subunit beta isoform X2 [KO:K13250]
104435278  B-cell receptor-associated protein 31 [KO:K14009]
104450251  uncharacterized protein LOC104450251 [KO:K14009]
104456529  B-cell receptor-associated protein 31 [KO:K14009]
104445699  B-cell receptor-associated protein 31 [KO:K14009]
120288368  B-cell receptor-associated protein 31-like [KO:K14009]
104449902  derlin-1.2 [KO:K13989]
104436269  derlin-1 [KO:K13989]
104431356  derlin-1.2-like [KO:K13989]
104445722  derlin-2.2 isoform X1 [KO:K13989]
104414321  caldesmon [KO:K24348]
104444551  plant UBX domain-containing protein 11 [KO:K24348]
104453667  LOW QUALITY PROTEIN: plant UBX domain-containing protein 2 [KO:K14011]
120295281  LOW QUALITY PROTEIN: plant UBX domain-containing protein 2 [KO:K14011]
104435092  LOW QUALITY PROTEIN: plant UBX domain-containing protein 4 [KO:K14012]
104445677  plant UBX domain-containing protein 4 [KO:K14012]
104425081  cell division cycle protein 48 homolog [KO:K13525]
104425078  cell division cycle protein 48 homolog [KO:K13525]
104417839  cell division cycle protein 48 homolog [KO:K13525]
104426715  NPL4-like protein 1 [KO:K14015]
104453384  ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
104420006  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
104420897  heat shock cognate 70 kDa protein 2 [KO:K03283]
104420900  heat shock cognate 70 kDa protein 2 [KO:K03283]
104450645  heat shock 70 kDa protein [KO:K03283]
104450646  heat shock 70 kDa protein-like [KO:K03283]
104423239  heat shock 70 kDa protein [KO:K03283]
104452509  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
104445208  LOW QUALITY PROTEIN: heat shock cognate 70 kDa protein 2 [KO:K03283]
104430869  heat shock 70 kDa protein 4 [KO:K03283]
120296392  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
104421160  dnaJ protein homolog [KO:K09503]
104442298  dnaJ protein homolog [KO:K09503]
104421364  dnaJ protein homolog [KO:K09503]
104428484  LOW QUALITY PROTEIN: chaperone protein dnaJ 49 [KO:K09518]
104436673  chaperone protein dnaJ 49 [KO:K09518]
104448346  heat shock protein 83 [KO:K04079]
104436694  heat shock cognate protein 80 [KO:K04079]
104443842  heat shock protein 90-1 [KO:K04079]
104450406  heat shock cognate protein 80 [KO:K04079]
104424446  heat shock protein 83 [KO:K04079]
104436723  hsp70 nucleotide exchange factor fes1 [KO:K09562]
104433747  nucleotide exchange factor SIL1 isoform X1 [KO:K09562]
104437376  small heat shock protein, chloroplastic [KO:K13993]
104435307  18.1 kDa class I heat shock protein-like [KO:K13993]
104439154  18.1 kDa class I heat shock protein-like [KO:K13993]
104433086  LOW QUALITY PROTEIN: class I heat shock protein-like [KO:K13993]
104432744  17.4 kDa class I heat shock protein [KO:K13993]
104437870  17.9 kDa class II heat shock protein [KO:K13993]
104436331  17.1 kDa class II heat shock protein [KO:K13993]
104422452  18.1 kDa class I heat shock protein-like [KO:K13993]
104421710  18.1 kDa class I heat shock protein [KO:K13993]
104422443  18.1 kDa class I heat shock protein [KO:K13993]
104422449  18.1 kDa class I heat shock protein [KO:K13993]
104422442  18.1 kDa class I heat shock protein [KO:K13993]
104450557  26.5 kDa heat shock protein, mitochondrial [KO:K13993]
104443693  23.6 kDa heat shock protein, mitochondrial isoform X2 [KO:K13993]
104422451  18.1 kDa class I heat shock protein [KO:K13993]
104451046  18.1 kDa class I heat shock protein [KO:K13993]
104423843  18.1 kDa class I heat shock protein [KO:K13993]
104449754  15.7 kDa heat shock protein, peroxisomal isoform X2 [KO:K13993]
104452453  22.7 kDa class IV heat shock protein [KO:K13993]
104415724  small heat shock protein, chloroplastic [KO:K13993]
104450758  22.0 kDa class IV heat shock protein [KO:K13993]
104441393  15.4 kDa class V heat shock protein [KO:K13993]
104441908  23.6 kDa heat shock protein, mitochondrial-like [KO:K13993]
104441911  small heat shock protein, chloroplastic isoform X1 [KO:K13993]
104422428  18.1 kDa class I heat shock protein [KO:K13993]
104422433  18.1 kDa class I heat shock protein [KO:K13993]
104422431  18.1 kDa class I heat shock protein-like [KO:K13993]
104422427  LOW QUALITY PROTEIN: 17.5 kDa class I heat shock protein [KO:K13993]
104422434  18.1 kDa class I heat shock protein [KO:K13993]
104422438  18.1 kDa class I heat shock protein [KO:K13993]
104422440  18.1 kDa class I heat shock protein [KO:K13993]
104419505  17.4 kDa class III heat shock protein [KO:K13993]
104422425  18.1 kDa class I heat shock protein [KO:K13993]
104427851  class I heat shock protein [KO:K13993]
104430446  18.1 kDa class I heat shock protein [KO:K13993]
104430445  18.1 kDa class I heat shock protein-like [KO:K13993]
104431598  18.1 kDa class I heat shock protein-like [KO:K13993]
104422426  18.1 kDa class I heat shock protein [KO:K13993]
104424548  small heat shock protein, chloroplastic [KO:K13993]
104431659  18.1 kDa class I heat shock protein-like [KO:K13993]
120288296  18.1 kDa class I heat shock protein-like [KO:K13993]
104433088  class I heat shock protein-like [KO:K13993]
120289011  18.1 kDa class I heat shock protein-like [KO:K13993]
120289203  18.1 kDa class I heat shock protein-like [KO:K13993]
120289213  18.1 kDa class I heat shock protein-like [KO:K13993]
120289214  18.1 kDa class I heat shock protein-like [KO:K13993]
120291863  17.6 kDa class I heat shock protein 3-like [KO:K13993]
120295753  18.1 kDa class I heat shock protein-like [KO:K13993]
104448238  OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 2 [KO:K13719] [EC:3.1.2.-]
104420540  phospholipase A-2-activating protein [KO:K14018]
104423249  ubiquitin receptor RAD23b isoform X1 [KO:K10839]
104453472  ubiquitin domain-containing protein DSK2a [KO:K04523]
104419027  ubiquitin domain-containing protein DSK2b [KO:K04523]
104415458  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
104415459  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X1 [KO:K01456] [EC:3.5.1.52]
104433110  ataxin-3 homolog [KO:K11863] [EC:3.4.22.-]
104427848  ataxin-3 homolog [KO:K11863] [EC:3.4.22.-]
120289971  ataxin-3 homolog [KO:K11863] [EC:3.4.22.-]
104419398  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
104454416  eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
120296384  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
104438271  subtilisin-like protease SBT6.1 isoform X1 [KO:K08653] [EC:3.4.21.112]
104445846  membrane-bound transcription factor site-2 protease homolog [KO:K07765] [EC:3.4.24.85]
104422845  serine/threonine-protein kinase/endoribonuclease IRE1a isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
104422847  serine/threonine-protein kinase/endoribonuclease IRE1b isoform X3 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
104422848  serine/threonine-protein kinase/endoribonuclease IRE1b [KO:K08852] [EC:2.7.11.1 3.1.26.-]
104422851  serine/threonine-protein kinase/endoribonuclease IRE1a isoform X2 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
104422870  serine/threonine-protein kinase/endoribonuclease IRE1a [KO:K08852] [EC:2.7.11.1 3.1.26.-]
104437176  serine/threonine-protein kinase/endoribonuclease IRE1a isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
104424005  serine/threonine-protein kinase/endoribonuclease IRE1a isoform X2 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
108958537  serine/threonine-protein kinase/endoribonuclease IRE1a-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
108958178  serine/threonine-protein kinase/endoribonuclease IRE1a-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
120291819  inactive serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
104418710  LOW QUALITY PROTEIN: probable E3 ubiquitin ligase SUD1 [KO:K10661] [EC:2.3.2.27]
104450726  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
104422891  ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:2.3.2.23]
104420906  ubiquitin-conjugating enzyme E2 14 isoform X1 [KO:K10575] [EC:2.3.2.23]
120285857  ubiquitin-conjugating enzyme E2 14 [KO:K10575] [EC:2.3.2.23]
104424282  ERAD-associated E3 ubiquitin-protein ligase HRD1B isoform X1 [KO:K10601] [EC:2.3.2.27]
104440652  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
104445287  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
104445979  uncharacterized ATP-dependent helicase IRC20 [KO:K10666] [EC:2.3.2.27]
104441016  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
104416415  E3 ubiquitin ligase rnf-5 [KO:K10666] [EC:2.3.2.27]
104419774  E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
104422250  LOW QUALITY PROTEIN: ERAD-associated E3 ubiquitin-protein ligase component HRD3A [KO:K14026]
104423517  ERAD-associated E3 ubiquitin-protein ligase component HRD3A [KO:K14026]
104424344  E3 ubiquitin protein ligase RIN2 [KO:K10636] [EC:2.3.2.36]
104425689  E3 ubiquitin-protein ligase CHIP isoform X2 [KO:K09561] [EC:2.3.2.27]
104453430  ubiquitin-conjugating enzyme E2 5B [KO:K06689] [EC:2.3.2.23]
104419641  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
104450384  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
104442151  LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
104445784  ubiquitin-conjugating enzyme E2 11 [KO:K06689] [EC:2.3.2.23]
104443966  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
104424465  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
104441683  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
104437993  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
104436408  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
104439002  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
104415121  cullin-1 [KO:K03347]
104425941  LOW QUALITY PROTEIN: cullin-1 [KO:K03347]
104425962  cullin-1 isoform X1 [KO:K03347]
104426047  cullin-1 isoform X1 [KO:K03347]
104434733  cullin-1 isoform X1 [KO:K03347]
104426051  cullin-1 isoform X2 [KO:K03347]
104415119  LOW QUALITY PROTEIN: cullin-1 [KO:K03347]
104448856  SKP1-like protein 1B [KO:K03094]
104422792  SKP1-like protein 1B [KO:K03094]
104422794  SKP1-like protein 1B [KO:K03094]
104444261  SKP1-like protein 1B [KO:K03094]
104418954  SKP1-like protein 11 [KO:K03094]
104418953  SKP1-like protein 1A [KO:K03094]
104418952  SKP1-like protein 1A [KO:K03094]
104418955  SKP1-like protein 1A [KO:K03094]
104418956  SKP1-like protein 1A [KO:K03094]
104420786  SKP1-like protein 1B [KO:K03094]
104419631  SKP1-like protein 1B isoform X1 [KO:K03094]
104419632  SKP1-like protein 1B [KO:K03094]
104419633  SKP1-like protein 1B [KO:K03094]
120291307  SKP1-like protein 1A [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
egr00510  N-Glycan biosynthesis
egr03050  Proteasome
egr03060  Protein export
KO pathway
ko04141   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (247)   
   KEGG GENES (247)   
All databases (248)   

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