KEGG   PATHWAY: ehi03013
Entry
ehi03013                    Pathway                                
Name
Nucleocytoplasmic transport - Entamoeba histolytica
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
ehi03013  Nucleocytoplasmic transport
ehi03013

Other DBs
GO: 0050658
Organism
Entamoeba histolytica [GN:ehi]
Gene
EHI_082600  145.t00001; DEAD/DEAH box helicase [KO:K18655] [EC:5.6.2.7]
EHI_118780  62.t00017; WD domain containing protein [KO:K14298]
EHI_147470  51.t00013; ubiquitin-conjugating enzyme family protein [KO:K10577]
EHI_178500  96.t00004; ubiquitin-conjugating enzyme family protein [KO:K10577]
EHI_001050  264.t00015; sec 13 protein [KO:K14004]
EHI_183510  56.t00027; nuclear pore protein [KO:K14314]
EHI_006820  53.t00021; importin alpha [KO:K23583]
EHI_124900  importin alpha-1 subunit [KO:K15042]
EHI_036520  158.t00014; importin beta [KO:K14293]
EHI_171760  93.t00018; hypothetical protein [KO:K14293]
EHI_097470  304.t00002; HEAT repeat domain containing protein [KO:K20221]
EHI_064450  65.t00010; HEAT repeat domain containing protein [KO:K20222]
EHI_081250  7.t00073; Importin beta-3 family protein [KO:K20222]
EHI_001760  284.t00010; importin [KO:K20223]
EHI_111750  247.t00013; importin alpha re-exporter [KO:K18423]
EHI_029040  110.t00019; exportin T [KO:K14288]
EHI_040630  164.t00011; hypothetical protein [KO:K25204]
EHI_009630  47.t00026; Ran-binding protein [KO:K18460]
EHI_148190  1.t00138; Ran family GTPase [KO:K07936]
EHI_052400  403.t00006; elongation factor 1-alpha 1 [KO:K03231]
EHI_102170  470.t00004; elongation factor 1-alpha 1 [KO:K03231]
EHI_011210  143.t00006; elongation factor 1-alpha 1 [KO:K03231]
EHI_156270  100.t00009; RNA recognition motif domain containing protein [KO:K12883]
EHI_104460  38.t00026; nonsense-mediated mRNA decay protein [KO:K07562]
EHI_083120  578.t00005; Nonsense-mediated mRNA decay protein 3 [KO:K07562]
EHI_138960  154.t00023; mago nashi protein [KO:K12877]
EHI_106300  5.t00083; DEAD/DEAH box helicase [KO:K13025] [EC:5.6.2.7]
EHI_035550  17.t00041; regulator of nonsense transcripts [KO:K14326] [EC:5.6.2.5 5.6.2.3]
EHI_068520  61.t00032; hypothetical protein [KO:K14327]
EHI_080900  251.t00008; hypothetical protein [KO:K14284]
EHI_035490  17.t00035; hypothetical protein [KO:K14284]
EHI_182830  28.t00012; hypothetical protein [KO:K14284]
EHI_044880  3.t00008; nuclear transport factor 2-like export factor 2 [KO:K14285]
EHI_151600  22.t00040; helicase [KO:K12812] [EC:5.6.2.7]
EHI_150160  ATP-dependent RNA helicase DDX39 [KO:K12812] [EC:5.6.2.7]
EHI_036900  283.t00009; DEAD/DEAH box helicase [KO:K12812] [EC:5.6.2.7]
EHI_013250  14.t00046; splicing factor [KO:K13171]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
ehi03015  mRNA surveillance pathway
KO pathway
ko03013   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (37)   
   KEGG GENES (37)   
All databases (38)   

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