KEGG   PATHWAY: ehi03060
Entry
ehi03060                    Pathway                                
Name
Protein export - Entamoeba histolytica
Description
The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ehi03060  Protein export
ehi03060

Other DBs
GO: 0043952 0043953
Organism
Entamoeba histolytica [GN:ehi]
Gene
EHI_004750  203.t00021; signal recognition particle protein SRP54 [KO:K03106] [EC:3.6.5.4]
EHI_164500  467.t00007; Sec61 alpha subunit [KO:K10956]
EHI_048170  108.t00029; Protein transport protein SEC61 gamma subunit [KO:K07342]
EHI_038990  7.t00045; Protein transport protein SEC61 gamma subunit [KO:K07342]
EHI_134630  373.t00002; DnaJ domain containing protein [KO:K09540]
EHI_199590  45.t00004; 70 kDa heat shock protein [KO:K09490] [EC:3.6.4.10]
EHI_001950  90.t00019; heat shock protein 70 family [KO:K09490] [EC:3.6.4.10]
EHI_133950  heat shock protein 70 [KO:K09490] [EC:3.6.4.10]
EHI_130160  heat shock protein 70 [KO:K09490] [EC:3.6.4.10]
EHI_043000  111.t00021; heat shock protein 70 [KO:K09490] [EC:3.6.4.10]
EHI_185120  450.t00003; heat shock protein 70 [KO:K09490] [EC:3.6.4.10]
EHI_179380  188.t00016; hypothetical protein [KO:K03109]
EHI_146790  335.t00012; hypothetical protein [KO:K03107]
EHI_006160  83.t00029; Signal recognition particle 19 kDa protein [KO:K03105]
EHI_200840  109.t00019; Signal recognition particle receptor alpha subunit [KO:K13431]
EHI_000670  hypothetical protein [KO:K12272]
EHI_092570  hypothetical protein [KO:K12272]
EHI_177400  323.t00007; arsenite-translocating ATPase [KO:K01551] [EC:7.3.2.7 7.3.-.-]
EHI_146980  276.t00006; hypothetical protein [KO:K16365]
EHI_068570  61.t00039; hypothetical protein [KO:K27164]
EHI_193470  hypothetical protein [KO:K12946] [EC:3.4.-.-]
EHI_200720  hypothetical protein [KO:K12946] [EC:3.4.-.-]
EHI_105770  9.t00073; hypothetical protein [KO:K12947] [EC:3.4.-.-]
EHI_051790  84.t00022; hypothetical protein [KO:K12947] [EC:3.4.-.-]
EHI_121860  147.t00015; microsomal signal peptidase subunit [KO:K12948] [EC:3.4.-.-]
EHI_197020  92.t00019; signal peptidase [KO:K13280] [EC:3.4.21.89]
Reference
  Authors
Dalbey RE, Robinson C.
  Title
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
  Journal
Trends Biochem Sci 24:17-22 (1999)
DOI:10.1016/S0968-0004(98)01333-4
Reference
  Authors
Berks BC, Sargent F, Palmer T.
  Title
The Tat protein export pathway.
  Journal
Mol Microbiol 35:260-74 (2000)
DOI:10.1046/j.1365-2958.2000.01719.x
Reference
  Authors
Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
  Title
TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
  Journal
J Biol Chem 275:16717-22 (2000)
DOI:10.1074/jbc.M000800200
Reference
  Authors
Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
  Title
TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
  Journal
J Biol Chem 275:41350-7 (2000)
DOI:10.1074/jbc.M004887200
Reference
  Authors
Rapoport TA
  Title
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
  Journal
Nature 450:663-9 (2007)
DOI:10.1038/nature06384
Reference
  Authors
Flower AM
  Title
The SecY translocation complex: convergence of genetics and structure.
  Journal
Trends Microbiol 15:203-10 (2007)
DOI:10.1016/j.tim.2007.03.001
Reference
  Authors
Osborne AR, Rapoport TA, van den Berg B
  Title
Protein translocation by the Sec61/SecY channel.
  Journal
Annu Rev Cell Dev Biol 21:529-50 (2005)
DOI:10.1146/annurev.cellbio.21.012704.133214
Reference
  Authors
Paetzel M, Karla A, Strynadka NC, Dalbey RE
  Title
Signal peptidases.
  Journal
Chem Rev 102:4549-80 (2002)
DOI:10.1021/cr010166y
Reference
  Authors
Paetzel M, Dalbey RE, Strynadka NC
  Title
The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
  Journal
Pharmacol Ther 87:27-49 (2000)
DOI:10.1016/S0163-7258(00)00064-4
Reference
  Authors
Ng SY, Chaban B, VanDyke DJ, Jarrell KF
  Title
Archaeal signal peptidases.
  Journal
Microbiology 153:305-14 (2007)
DOI:10.1099/mic.0.2006/003087-0
Reference
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03060   

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