KEGG   PATHWAY: ehi04141
Entry
ehi04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Entamoeba histolytica
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ehi04141  Protein processing in endoplasmic reticulum
ehi04141

Other DBs
GO: 0030433 0034976
Organism
Entamoeba histolytica [GN:ehi]
Gene
EHI_164500  467.t00007; Sec61 alpha subunit [KO:K10956]
EHI_048170  108.t00029; Protein transport protein SEC61 gamma subunit [KO:K07342]
EHI_038990  7.t00045; Protein transport protein SEC61 gamma subunit [KO:K07342]
EHI_134630  373.t00002; DnaJ domain containing protein [KO:K09540]
EHI_029540  248.t00006; dolychil-diphosphooligosaccharide-- protein glycosyltransferase subunit [KO:K12666]
EHI_103780  85.t00026; defender against cell death protein [KO:K12668]
EHI_028900  192.t00010; dolichyl-diphosphooligosaccharide-protein glycotransferase [KO:K12670]
EHI_069430  364.t00008; dolichyl-di-phosphooligosaccharide-protein glycotransferase [KO:K12670]
EHI_011940  16.t00004; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
EHI_118880  62.t00006; Oligosaccharyl transferase [KO:K07151] [EC:2.4.99.18]
EHI_096150  6.t00011; hypothetical protein [KO:K26501]
EHI_199590  45.t00004; 70 kDa heat shock protein [KO:K09490] [EC:3.6.4.10]
EHI_001950  90.t00019; heat shock protein 70 family [KO:K09490] [EC:3.6.4.10]
EHI_133950  heat shock protein 70 [KO:K09490] [EC:3.6.4.10]
EHI_130160  heat shock protein 70 [KO:K09490] [EC:3.6.4.10]
EHI_043000  111.t00021; heat shock protein 70 [KO:K09490] [EC:3.6.4.10]
EHI_185120  450.t00003; heat shock protein 70 [KO:K09490] [EC:3.6.4.10]
EHI_023430  25.t00013; glucosidase [KO:K05546] [EC:3.2.1.207]
EHI_135420  glucosidase 2 subunit beta precursor [KO:K08288]
EHI_136160  33.t00005; calreticulin [KO:K08057]
EHI_031410  377.t00003; GTP-binding protein [KO:K07953] [EC:3.6.5.-]
EHI_075210  63.t00030; GTP-binding protein [KO:K07953] [EC:3.6.5.-]
EHI_075040  GTP-binding protein [KO:K07953] [EC:3.6.5.-]
EHI_001050  264.t00015; sec 13 protein [KO:K14004]
EHI_103410  118.t00015; WD domain containing protein [KO:K14005]
EHI_008730  98.t00012; Sec23 protein [KO:K14006]
EHI_175480  315.t00007; Sec23 protein [KO:K14006]
EHI_048310  698.t00002; protein transport protein Sec24 [KO:K14007]
EHI_015280  52.t00010; UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
EHI_110350  5.t00007; thioredoxin [KO:K09580] [EC:5.3.4.1]
EHI_071590  206.t00013; protein disulfide isomerase [KO:K09584] [EC:5.3.4.1]
EHI_021560  253.t00005; thioredoxin [KO:K09584] [EC:5.3.4.1]
EHI_027550  1.t00031; thioredoxin [KO:K09584] [EC:5.3.4.1]
EHI_035580  17.t00045; Der1 family protein [KO:K13989]
EHI_074160  79.t00023; UBX domain protein [KO:K14011]
EHI_148540  1.t00100; hypothetical protein [KO:K14012]
EHI_176970  192.t00007; cdc48-like protein [KO:K13525]
EHI_026450  30.t00038; hypothetical protein [KO:K14015]
EHI_125920  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
EHI_052860  218.t00008; heat shock protein 70 [KO:K03283]
EHI_104330  38.t00041; heat shock protein70, hsp70A2 [KO:K03283]
EHI_002560  418.t00001; heat shock protein 70 [KO:K03283]
EHI_155490  71.t00020; heat shock protein 70 [KO:K03283]
EHI_180380  heat shock protein 70 [KO:K03283]
EHI_192510  69.t00023; hypothetical protein [KO:K03283]
EHI_198320  278.t00009; heat shock protein 70 [KO:K03283]
EHI_201260  136.t00006; heat shock protein 70 [KO:K03283]
EHI_021780  heat shock protein 70 [KO:K03283]
EHI_150770  584.t00001; heat shock protein 70 [KO:K03283]
EHI_113410  7.t00068; heat shock protein 70 [KO:K03283]
EHI_188610  heat shock protein 70 [KO:K03283]
EHI_192440  69.t00034; heat shock protein70, hsp70A2 [KO:K03283]
EHI_079720  102.t00019; DnaJ family protein [KO:K09503]
EHI_073780  DNAJ homolog subfamily A member 2 [KO:K09503]
EHI_196940  92.t00009; heat shock protein 90 [KO:K04079]
EHI_102270  92.t00037; heat shock protein 90 [KO:K04079]
EHI_064430  65.t00008; OTU-like cysteine protease [KO:K13719] [EC:3.1.2.-]
EHI_001400  294.t00005; RAD23 protein [KO:K10839]
EHI_022980  81.t00019; ubiquitin-like protein [KO:K04523]
EHI_138180  35.t00023; hypothetical protein [KO:K10597] [EC:2.3.2.27]
EHI_005100  103.t00025; eukaryotic translation initiation factor 2 alpha subunit [KO:K03237]
EHI_068350  61.t00012; protein kinase [KO:K08852] [EC:2.7.11.1 3.1.26.-]
EHI_075540  253.t00012; protein kinase [KO:K08852] [EC:2.7.11.1 3.1.26.-]
EHI_150370  22.t00037; ubiquitin-conjugating enzyme family protein [KO:K04554] [EC:2.3.2.23]
EHI_048700  107.t00018; ubiquitin-conjugating enzyme family protein [KO:K10575] [EC:2.3.2.23]
EHI_124480  42.t00021; ubiquitin-conjugating enzyme family protein [KO:K04555] [EC:2.3.2.23]
EHI_166440  125.t00010; zinc finger domain containing protein [KO:K10601] [EC:2.3.2.27]
EHI_083560  108.t00020; ubiquitin-conjugating enzyme family protein [KO:K06689] [EC:2.3.2.23]
EHI_070750  54.t00036; ubiquitin-conjugating enzyme family protein [KO:K06689] [EC:2.3.2.23]
EHI_151630  2.t00108; RING finger protein [KO:K03868] [EC:2.3.2.32]
EHI_156450  100.t00027; cullin [KO:K03347]
EHI_118670  62.t00027; Skp1 protein [KO:K03094]
EHI_066770  181.t00006; Skp1 protein [KO:K03094]
EHI_134960  153.t00018; S-phase kinase-associated protein 1A [KO:K03094]
EHI_174130  116.t00012; Skp1 protein [KO:K03094]
EHI_174180  116.t00016; Skp1 protein [KO:K03094]
EHI_065310  glycoprotein FP21 precursor [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
ehi00510  N-Glycan biosynthesis
ehi03050  Proteasome
ehi03060  Protein export
KO pathway
ko04141   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (77)   
   KEGG GENES (77)   
All databases (78)   

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