KEGG   PATHWAY: emu02010
Entry
emu02010                    Pathway                                
Name
ABC transporters - Enterococcus mundtii
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
emu02010  ABC transporters
emu02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Enterococcus mundtii [GN:emu]
Gene
EMQU_1819  hypothetical protein HMPREF0994_05043 [KO:K02012]
EMQU_1820  hypothetical protein HMPREF9488_02368 [KO:K02011]
EMQU_1821  ABC transporter family protein [KO:K02010] [EC:7.2.2.7]
EMQU_2099  spermidine/putrescine ABC transporter substrate-binding protein [KO:K11069]
EMQU_2100  potC; spermidine/putrescine ABC superfamily ATP binding cassette transporter, membrane protein [KO:K11070]
EMQU_2101  potB; spermidine/putrescine ABC superfamily ATP binding cassette transporter, membrane protein [KO:K11071]
EMQU_2102  potA; spermidine/putrescine import ATP-binding protein PotA [KO:K11072] [EC:7.6.2.11]
EMQU_2442  proWX; glycine betaine/carnitine/choline ABC superfamily ATP binding cassette transporter, membrane/binding protein [KO:K02001 K02002]
EMQU_2443  glycine betaine/L-proline ABC transporter ATP-binding protein [KO:K02000] [EC:7.6.2.9]
EMQU_0216  opuCC; glycine/betaine/carnitine/choline ABC superfamily ATP binding cassette transporter, binding protein [KO:K05845]
EMQU_1132  ABC transporter permease [KO:K05845 K05846]
EMQU_0215  opuCD; glycine/betaine/carnitine/choline ABC superfamily ATP binding cassette transporter, membrane protein [KO:K05846]
EMQU_0217  opuCB; glycine/betaine/carnitine/choline ABC superfamily ATP binding cassette transporter, membrane protein [KO:K05846]
EMQU_0218  opuAA; glycine/betaine/carnitine/choline ABC superfamily ATP binding cassette transporter, ABC protein [KO:K05847] [EC:7.6.2.9]
EMQU_1133  choline ABC transporter ATP-binding protein [KO:K05847] [EC:7.6.2.9]
EMQU_1473  ABC superfamily ATP binding cassette transporter, ABC protein [KO:K10112] [EC:7.5.2.-]
EMQU_0635  sugar ABC transporter ATP-binding protein [KO:K10112] [EC:7.5.2.-]
EMQU_1434  malX; maltose/maltodextrin ABC superfamily ATP binding cassette transporter, binding protein [KO:K15770]
EMQU_1433  malC; maltose/maltodextrin ABC superfamily ATP binding cassette transporter, membrane protein [KO:K15771]
EMQU_1432  mdxG; maltose/maltodextrin ABC transporter permease [KO:K15772]
EMQU_1582  lactose ABC superfamily ATP binding cassette transporter, binding protein [KO:K10188]
EMQU_1581  lacF2; lactose ABC superfamily ATP binding cassette transporter, membrane protein [KO:K10189]
EMQU_1580  lacG2; lactose ABC superfamily ATP binding cassette transporter, membrane protein [KO:K10190]
EMQU_2671  multiple sugar ABC transporter substrate-binding protein [KO:K17318]
EMQU_2673  sugar ABC transporter permease [KO:K17319]
EMQU_2672  ypcH; carbohydrate ABC superfamily ATP binding cassette transporter, membrane protein [KO:K17320]
EMQU_1845  sugar ABC superfamily ATP binding cassette transporter, binding protein [KO:K10546]
EMQU_1843  araH; L-arabinose ABC superfamily ATP binding cassette transporter, membrane protein [KO:K10547]
EMQU_1844  araG; L-arabinose ABC superfamily ATP binding cassette transporter, ABC protein [KO:K10548] [EC:7.5.2.-]
EMQU_0067  hypothetical protein [KO:K07335]
EMQU_0069  ABC transporter permease [KO:K23535]
EMQU_0070  ABC transporter permease [KO:K23536]
EMQU_0068  ABC transporter ATP-binding protein [KO:K23537]
EMQU_2806  periplasmic ribose-binding protein [KO:K10439]
EMQU_2807  Ribose transport system permease protein rbsC [KO:K10440]
EMQU_2808  araG; L-arabinose ABC superfamily ATP binding cassette transporter, ABC protein [KO:K10441] [EC:7.5.2.7]
EMQU_2382  ribose transport protein rbsD [KO:K06726] [EC:5.4.99.62]
EMQU_1846  ABC superfamily ATP binding cassette transporter, binding protein [KO:K23508]
EMQU_1880  pstS; phosphate ABC transporter ATP-binding protein [KO:K02040]
EMQU_1963  phosphate ABC transporter substrate-binding protein [KO:K02040]
EMQU_1962  pstC; phosphate ABC superfamily ATP binding cassette transporter, membrane protein [KO:K02037]
EMQU_1961  pstA; phosphate ABC superfamily ATP binding cassette transporter, membrane protein [KO:K02038]
EMQU_1959  phosphate ABC transporter ATP-binding protein [KO:K02036] [EC:7.3.2.1]
EMQU_1960  pstB2; phosphate ABC superfamily ATP binding cassette transporter, ABC protein [KO:K02036] [EC:7.3.2.1]
EMQU_2196  phosphonate ABC transporter [KO:K02044]
EMQU_2193  phosphonate ABC transporter permease [KO:K02042]
EMQU_2194  phnE; phosphonate ABC transporter, permease protein PhnE [KO:K02042]
EMQU_2195  phnC; phosphonate ABC transporter ATPase [KO:K02041] [EC:7.3.2.2]
EMQU_1644  amino acid ABC transporter amino acid-binding/permease protein [KO:K10036 K10037]
EMQU_1645  amino acid ABC transporter ATP-binding protein [KO:K10038] [EC:7.4.2.1]
EMQU_1251  glutamine-binding periplasmic protein [KO:K10039]
EMQU_1252  glnC; glutamate ABC superfamily ATP binding cassette transporter, membrane protein [KO:K10040]
EMQU_1253  glutamine transport system permease protein GlnP [KO:K10040]
EMQU_1250  glnQ; glutamate ABC superfamily ATP binding cassette transporter, ABC protein [KO:K10041] [EC:7.4.2.1]
EMQU_0977  amino acid transporter amino acid-binding protein [KO:K23059]
EMQU_0978  polar amino acid ABC transporter permease [KO:K17077]
EMQU_0979  phosphate ABC transporter ATP-binding protein [KO:K23060] [EC:7.4.2.1]
EMQU_0177  amino acid ABC transporter amino acid-binding/permease protein [KO:K17073 K17074]
EMQU_0176  amino acid ABC superfamily ATP binding cassettetransporter, ABC protein [KO:K17076]
EMQU_0036  yaeC family lipoprotein [KO:K02073]
EMQU_2154  yaeC family lipoprotein [KO:K02073]
EMQU_2314  metal ion ABC superfamily ATP binding cassette transporter, binding protein [KO:K02073]
EMQU_0035  ABC transporter permease [KO:K02072]
EMQU_2155  metI; D-methionine ABC superfamily ATP binding cassette transporter, membrane protein [KO:K02072]
EMQU_2315  metal ion ABC superfamily ATP binding cassette transporter, membrane protein [KO:K02072]
EMQU_0034  ABC transporter ATP-binding protein [KO:K02071]
EMQU_2156  metN; D-methionine ABC superfamily ATP binding cassette transporter, ABC protein [KO:K02071]
EMQU_2316  metN2; ABC transporter ATP-binding protein [KO:K02071]
EMQU_0616  peptide ABC transporter peptide-binding protein [KO:K15580]
EMQU_0618  dppB; oligopeptide ABC superfamily ATP binding cassette transporter, membrane protein [KO:K15581]
EMQU_0619  peptide ABC transporter permease [KO:K15582]
EMQU_0620  peptide ABC transporter ATP-binding protein [KO:K15583]
EMQU_0621  dppF; oligopeptide ABC superfamily ATP binding cassette transporter, ABC protein [KO:K10823]
EMQU_0559  psaA; manganese ABC superfamily ATP binding cassette transporter, binding protein [KO:K19975]
EMQU_0558  ABC transporter permease [KO:K19976]
EMQU_0557  ABC superfamily ATP binding cassette transporter, ABC protein [KO:K19973] [EC:7.2.2.5]
EMQU_2743  adhesion lipoprotein [KO:K09815]
EMQU_0428  zinc-binding lipoprotein AdcA [KO:K09815]
EMQU_2741  adcB; zinc ABC superfamily ATP binding cassette transporter, membrane protein [KO:K09816]
EMQU_2742  ABC transporter ATP-binding protein [KO:K09817] [EC:7.2.2.20]
EMQU_0154  bioY; biotin synthase [KO:K03523]
EMQU_0114  cobalt transport family protein [KO:K16785]
EMQU_0112  cobalt ABC superfamily ATP binding cassette transporter, ABC protein [KO:K16786] [EC:7.-.-.-]
EMQU_0113  cbiO2; cobalt transporter ATP-binding subunit [KO:K16787] [EC:7.-.-.-]
EMQU_0900  ABC transporter permease [KO:K09692]
EMQU_0901  tagH; teichoic acid ABC superfamily ATP binding cassette transporter, ABC protein [KO:K09693] [EC:7.5.2.4]
EMQU_0741  ABC superfamily ATP binding cassette transporter, membrane protein [KO:K11632]
EMQU_0740  ABC transporter ATP-binding protein [KO:K11631]
EMQU_0739  ABC transporter ATP-binding protein [KO:K11631]
EMQU_1965  cell division ABC transporter permease FtsX [KO:K09811]
EMQU_1966  ftsE; ABC superfamily ATP binding cassette transporter, ABC protein [KO:K09812]
EMQU_1933  multidrug resistance-like ATP-binding protein mdlA [KO:K18889]
EMQU_1932  mdlB; multidrug ABC superfamily ATP binding cassette transporter, ABC/membrane protein [KO:K18890]
EMQU_2690  ABC superfamily ATP binding cassette transporter, membrane protein [KO:K18891]
EMQU_2689  ABC transporter ATP-binding protein/permease [KO:K18892]
EMQU_0703  ABC transporter ATP-binding protein/permease [KO:K18887]
EMQU_2388  lmrA; multidrug resistance ABC superfamily ATP binding cassette transporter, ABC/membrane protein [KO:K18887]
EMQU_1591  ABC transporter ATP-binding protein/permease [KO:K18887]
EMQU_0641  ABC transporter ATP-binding protein/permease [KO:K18887]
EMQU_0704  ABC transporter ATP-binding protein/permease [KO:K18888]
EMQU_1592  ABC superfamily ATP binding cassette transporter, membrane protein [KO:K18888]
EMQU_0640  ABC transporter ATP-binding protein/permease [KO:K18888]
EMQU_2387  ABC transporter ATP-binding protein/permease [KO:K18888]
EMQU_3204  bacteriocin ABC transporter [KO:K20344]
EMQU_2574  ABC superfamily ATP binding cassette transporter, ABC protein [KO:K18231]
EMQU_2147  ABC superfamily ATP binding cassette transporter, ABC protein [KO:K19350]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   

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