KEGG   PATHWAY: emu03440
Entry
emu03440                    Pathway                                
Name
Homologous recombination - Enterococcus mundtii
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
emu03440  Homologous recombination
emu03440

Other DBs
GO: 0000724
Organism
Enterococcus mundtii [GN:emu]
Gene
EMQU_1270  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
EMQU_0008  single-strand binding protein [KO:K03111]
EMQU_3080  single-strand DNA binding protein [KO:K03111]
EMQU_3032  ssb-6; single-strand binding protein [KO:K03111]
EMQU_3147  single-strand DNA binding protein [KO:K03111]
EMQU_0004  recF; recombination protein F [KO:K03629]
EMQU_1914  DNA repair protein RecO [KO:K03584]
EMQU_0726  recR; recombination protein RecR [KO:K06187]
EMQU_2752  recA; recombinase A [KO:K03553]
EMQU_1551  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
EMQU_0170  ruvA; Holliday junction DNA helicase RuvA [KO:K03550]
EMQU_0171  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
EMQU_0120  recG; DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
EMQU_2554  recD; exodeoxyribonuclease V subunit alpha [KO:K03581] [EC:3.1.11.5]
EMQU_1002  dnaE; DNA-directed DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
EMQU_1678  polC; DNA-directed DNA polymerase III subunit alpha [KO:K03763] [EC:2.7.7.7]
EMQU_0002  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
EMQU_0724  DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
EMQU_1201  holA; DNA-directed DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
EMQU_0729  holB; DNA-directed DNA polymerase III delta' subunit [KO:K02341] [EC:2.7.7.7]
EMQU_2116  exonuclease [KO:K02342] [EC:2.7.7.7]
EMQU_2729  priB; primosomal replication protein n [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG GENES (22)   
All databases (23)   

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