KEGG   PATHWAY: gla04145Help
Entry
gla04145                    Pathway                                

Name
Phagosome - Giardia lamblia
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
gla04145  Phagosome
gla04145

Ortholog table
Other DBs
GO: 0045335
Organism
Giardia lamblia [GN:gla]
Gene
GL50803_40817  Actin related protein [KO:K05692]
GL50803_11220  Syntaxin 18 [KO:K08492]
GL50803_9489  V-SNARE [KO:K08517]
GL50803_17406  Phosphoinositide-3-kinase, class 3 [KO:K00914] [EC:2.7.1.137]
GL50803_7532  Vacuolar ATP synthase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
GL50803_12216  Vacuolar ATP synthase subunit B [KO:K02147]
GL50803_87058  Vacuolar ATP synthase subunit C [KO:K02148]
GL50803_3678  Vacuolar ATP synthase subunit D [KO:K02149]
GL50803_13603  hypothetical protein [KO:K02150]
GL50803_8367  VATPase [KO:K02151]
GL50803_14660  hypothetical protein [KO:K02152]
GL50803_30851  hypothetical protein [KO:K02153]
GL50803_18470  Vacuolar proton-ATPase subunit, putative [KO:K02154]
GL50803_13000  Vacuolar ATP synthase subunit d [KO:K02146]
GL50803_14961  Vacuolar ATP synthase subunit H [KO:K02144]
GL50803_10530  Vacuolar ATP synthase 16 kDa proteolipid subunit [KO:K02155]
GL50803_8559  Vacuolar ATP synthase 16 kDa proteolipid subunit [KO:K02155]
GL50803_15598  Vacuolar ATP synthase 16 kDa proteolipid subunit [KO:K03661]
GL50803_17478  Dynein heavy chain [KO:K10413]
GL50803_93736  Dynein heavy chain [KO:K10414]
GL50803_103676  Alpha-tubulin [KO:K07374]
GL50803_112079  Alpha-tubulin [KO:K07374]
GL50803_101291  Beta tubulin [KO:K07375]
GL50803_136021  Beta tubulin [KO:K07375]
GL50803_136020  Beta tubulin [KO:K07375]
GL50803_5744  Sec61-alpha [KO:K10956]
GL50803_3896  Sec61-gamma [KO:K07342]
GL50803_8496  Rac/Rho-like protein [KO:K04392]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
KO pathway
ko04145   

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