KEGG   PATHWAY: hsa00020
Entry
hsa00020                    Pathway                                

Name
Citrate cycle (TCA cycle) - Homo sapiens (human)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
hsa00020  Citrate cycle (TCA cycle)
hsa00020

Module
hsa_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:hsa00020]
hsa_M00009  Citrate cycle (TCA cycle, Krebs cycle) [PATH:hsa00020]
hsa_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:hsa00020]
hsa_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:hsa00020]
hsa_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:hsa00020]
Drug
D10691  Bempedoic acid (USAN/INN)
D11090  Ivosidenib (USAN/INN)
D11834  Vorasidenib (USAN/INN)
D11835  Vorasidenib citrate (USAN)
Other DBs
GO: 0006099
Organism
Homo sapiens (human) [GN:hsa]
Gene
1431  CS; citrate synthase [KO:K01647] [EC:2.3.3.1]
47  ACLY; ATP citrate lyase [KO:K01648] [EC:2.3.3.8]
50  ACO2; aconitase 2 [KO:K01681] [EC:4.2.1.3]
48  ACO1; aconitase 1 [KO:K01681] [EC:4.2.1.3]
3417  IDH1; isocitrate dehydrogenase (NADP(+)) 1 [KO:K00031] [EC:1.1.1.42]
3418  IDH2; isocitrate dehydrogenase (NADP(+)) 2 [KO:K00031] [EC:1.1.1.42]
3420  IDH3B; isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta [KO:K00030] [EC:1.1.1.41]
3421  IDH3G; isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma [KO:K00030] [EC:1.1.1.41]
3419  IDH3A; isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha [KO:K00030] [EC:1.1.1.41]
55753  OGDHL; oxoglutarate dehydrogenase L [KO:K00164] [EC:1.2.4.2]
4967  OGDH; oxoglutarate dehydrogenase [KO:K00164] [EC:1.2.4.2]
1743  DLST; dihydrolipoamide S-succinyltransferase [KO:K00658] [EC:2.3.1.61]
1738  DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
8802  SUCLG1; succinate-CoA ligase GDP/ADP-forming subunit alpha [KO:K01899] [EC:6.2.1.4 6.2.1.5]
8801  SUCLG2; succinate-CoA ligase GDP-forming subunit beta [KO:K01900] [EC:6.2.1.4 6.2.1.5]
8803  SUCLA2; succinate-CoA ligase ADP-forming subunit beta [KO:K01900] [EC:6.2.1.4 6.2.1.5]
6389  SDHA; succinate dehydrogenase complex flavoprotein subunit A [KO:K00234] [EC:1.3.5.1]
6390  SDHB; succinate dehydrogenase complex iron sulfur subunit B [KO:K00235] [EC:1.3.5.1]
6391  SDHC; succinate dehydrogenase complex subunit C [KO:K00236]
6392  SDHD; succinate dehydrogenase complex subunit D [KO:K00237]
2271  FH; fumarate hydratase [KO:K01679] [EC:4.2.1.2]
4190  MDH1; malate dehydrogenase 1 [KO:K00025] [EC:1.1.1.37]
4191  MDH2; malate dehydrogenase 2 [KO:K00026] [EC:1.1.1.37]
5091  PC; pyruvate carboxylase [KO:K01958] [EC:6.4.1.1]
5105  PCK1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
5106  PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
5161  PDHA2; pyruvate dehydrogenase E1 subunit alpha 2 [KO:K00161] [EC:1.2.4.1]
5160  PDHA1; pyruvate dehydrogenase E1 subunit alpha 1 [KO:K00161] [EC:1.2.4.1]
5162  PDHB; pyruvate dehydrogenase E1 subunit beta [KO:K00162] [EC:1.2.4.1]
1737  DLAT; dihydrolipoamide S-acetyltransferase [KO:K00627] [EC:2.3.1.12]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 2)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 3)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa00053  Ascorbate and aldarate metabolism
hsa00061  Fatty acid biosynthesis
hsa00062  Fatty acid elongation
hsa00071  Fatty acid degradation
hsa00190  Oxidative phosphorylation
hsa00220  Arginine biosynthesis
hsa00250  Alanine, aspartate and glutamate metabolism
hsa00280  Valine, leucine and isoleucine degradation
hsa00350  Tyrosine metabolism
hsa00471  D-Glutamine and D-glutamate metabolism
hsa00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   

DBGET integrated database retrieval system