KEGG   PATHWAY: hsa01230
Entry
hsa01230                    Pathway                                

Name
Biosynthesis of amino acids - Homo sapiens (human)
Description
This map presents a modular architecture of the biosynthesis pathways of twenty amino acids, which may be viewed as consisting of the core part and its extensions. The core part is the KEGG module for conversion of three-carbon compounds from glyceraldehyde-3P to pyruvate [MD:M00002], together with the pathways around serine and glycine. This KEGG module is the most conserved one in the KEGG MODULE database and is found in almost all the completely sequenced genomes. The extensions are the pathways containing the reaction modules RM001, RM033, RM032, and RM002 for biosynthesis of branched-chain amino acids (left) and basic amino acids (bottom), and the pathways for biosynthesis of histidine and aromatic amino acids (top right). It is interesting to note that the so-called essential amino acids that cannot be synthesized in human and other organisms generally appear in these extensions. Furthermore, the bottom extension of basic amino acids appears to be most divergent containing multiple pathways for lysine biosynthesis and multiple gene sets for arginine biosynthesis.
Class
Pathway map
hsa01230  Biosynthesis of amino acids
hsa01230

Module
hsa_M00002  Glycolysis, core module involving three-carbon compounds [PATH:hsa01230]
hsa_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:hsa01230]
hsa_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:hsa01230]
hsa_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:hsa01230]
hsa_M00015  Proline biosynthesis, glutamate => proline [PATH:hsa01230]
hsa_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:hsa01230]
hsa_M00029  Urea cycle [PATH:hsa01230]
hsa_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:hsa01230]
hsa_M00844  Arginine biosynthesis, ornithine => arginine [PATH:hsa01230]
Drug
D10901  Enasidenib (USAN/INN)
D11044  Enasidenib mesylate (USAN)
D11695  Pegzilarginase (USAN/INN)
Organism
Homo sapiens (human) [GN:hsa]
KO pathway
ko01230   

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