KEGG   PATHWAY: hsa02010
Entry
hsa02010                    Pathway                                

Name
ABC transporters - Homo sapiens (human)
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
hsa02010  ABC transporters
hsa02010

Drug
D00219  Acetohexamide (JP17/USP/INN)
D00271  Chlorpropamide (JP17/USP/INN)
D00335  Glipizide (USP/INN)
D00336  Glyburide (USP)
D00379  Tolazamide (JAN/USP/INN)
D00380  Tolbutamide (JP17/USP/INN)
D00418  Minoxidil (JAN/USP/INN)
D00593  Glimepiride (JP17/USP/INN)
D00594  Repaglinide (JAN/USP/INN)
D01111  Nateglinide (JP17/USP/INN)
D01356  Glymidine sodium (JAN/USAN/INN)
D01599  Gliclazide (JP17/INN)
D01799  Glyclopyramide (JAN/INN)
D01810  Nicorandil (JP17/USAN/INN)
D01854  Mitiglinide calcium hydrate (JP17)
D02385  Levcromakalim (USAN/INN)
D02425  Carbutamide (INN)
D02427  Glibornuride (USAN/INN)
D02430  Gliquidone (INN)
D03128  Biricodar dicitrate (USAN)
D03968  Elacridar hydrochloride (USAN)
D04739  Linogliride (USAN/INN)
D04740  Linogliride fumarate (USAN)
D05114  Naminidil (USAN/INN)
D05482  Pinacidil (USAN)
D06008  Tariquidar (USAN/INN)
D06084  Tesmilifene hydrochloride (USAN)
D06177  Tolbutamide sodium, sterile
D06277  Valspodar (USAN/INN)
D06387  Zosuquidar trihydrochloride (USAN)
D07117  Metahexamide (INN)
D07118  Glisoxepide (INN)
D10134  Lumacaftor (USAN)
D10685  Lumacaftor and ivacaftor
D11041  Tezacaftor (USAN/INN)
D11042  Tezacaftor and ivacaftor
D11402  Olacaftor (USAN)
D11423  Deutivacaftor (USAN/INN)
D11507  Elexacaftor (USAN)
D11535  Bamocaftor (USAN)
D11536  Bamocaftor potassium (USAN)
D11683  Posenacaftor (USAN)
D11700  Elexacaftor, ivacaftor and tezacaftor
D11724  Galicaftor (USAN/INN)
D11782  Encequidar (USAN/INN)
D11783  Encequidar mesylate (USAN)
Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Homo sapiens (human) [GN:hsa]
Gene
1672  DEFB1; defensin beta 1 [KO:K23125]
19  ABCA1; ATP binding cassette subfamily A member 1 [KO:K05641]
20  ABCA2; ATP binding cassette subfamily A member 2 [KO:K05642]
21  ABCA3; ATP binding cassette subfamily A member 3 [KO:K05643]
24  ABCA4; ATP binding cassette subfamily A member 4 [KO:K05644]
10347  ABCA7; ATP binding cassette subfamily A member 7 [KO:K05645]
26154  ABCA12; ATP binding cassette subfamily A member 12 [KO:K05646]
154664  ABCA13; ATP binding cassette subfamily A member 13 [KO:K05647]
23461  ABCA5; ATP binding cassette subfamily A member 5 [KO:K05648]
23460  ABCA6; ATP binding cassette subfamily A member 6 [KO:K05649]
10351  ABCA8; ATP binding cassette subfamily A member 8 [KO:K05650]
10350  ABCA9; ATP binding cassette subfamily A member 9 [KO:K05651]
10349  ABCA10; ATP binding cassette subfamily A member 10 [KO:K05652]
6890  TAP1; transporter 1, ATP binding cassette subfamily B member [KO:K05653]
6891  TAP2; transporter 2, ATP binding cassette subfamily B member [KO:K05654]
11194  ABCB8; ATP binding cassette subfamily B member 8 [KO:K05655]
23457  ABCB9; ATP binding cassette subfamily B member 9 [KO:K05656]
23456  ABCB10; ATP binding cassette subfamily B member 10 [KO:K05657]
5243  ABCB1; ATP binding cassette subfamily B member 1 [KO:K05658] [EC:7.6.2.2]
5244  ABCB4; ATP binding cassette subfamily B member 4 [KO:K05659] [EC:7.6.2.2]
340273  ABCB5; ATP binding cassette subfamily B member 5 [KO:K05660]
10058  ABCB6; ATP binding cassette subfamily B member 6 (Langereis blood group) [KO:K05661]
22  ABCB7; ATP binding cassette subfamily B member 7 [KO:K05662]
8647  ABCB11; ATP binding cassette subfamily B member 11 [KO:K05664]
4363  ABCC1; ATP binding cassette subfamily C member 1 [KO:K05665] [EC:7.6.2.3]
1244  ABCC2; ATP binding cassette subfamily C member 2 [KO:K05666]
8714  ABCC3; ATP binding cassette subfamily C member 3 [KO:K05667]
10257  ABCC4; ATP binding cassette subfamily C member 4 [KO:K05673]
10057  ABCC5; ATP binding cassette subfamily C member 5 [KO:K05668]
368  ABCC6; ATP binding cassette subfamily C member 6 [KO:K05669]
89845  ABCC10; ATP binding cassette subfamily C member 10 [KO:K05674]
85320  ABCC11; ATP binding cassette subfamily C member 11 [KO:K05671]
94160  ABCC12; ATP binding cassette subfamily C member 12 [KO:K05672]
1080  CFTR; CF transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
6833  ABCC8; ATP binding cassette subfamily C member 8 [KO:K05032]
10060  ABCC9; ATP binding cassette subfamily C member 9 [KO:K05033]
215  ABCD1; ATP binding cassette subfamily D member 1 [KO:K05675]
225  ABCD2; ATP binding cassette subfamily D member 2 [KO:K05676]
5825  ABCD3; ATP binding cassette subfamily D member 3 [KO:K05677]
5826  ABCD4; ATP binding cassette subfamily D member 4 [KO:K05678]
9619  ABCG1; ATP binding cassette subfamily G member 1 [KO:K05679]
64137  ABCG4; ATP binding cassette subfamily G member 4 [KO:K05680]
9429  ABCG2; ATP binding cassette subfamily G member 2 (Junior blood group) [KO:K05681]
64240  ABCG5; ATP binding cassette subfamily G member 5 [KO:K05683]
64241  ABCG8; ATP binding cassette subfamily G member 8 [KO:K05684]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00753  Tungsten
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  D-Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   

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