KEGG   PATHWAY: lbz04141
Entry
lbz04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Leishmania braziliensis
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
lbz04141  Protein processing in endoplasmic reticulum
lbz04141

Other DBs
GO: 0030433 0034976
Organism
Leishmania braziliensis [GN:lbz]
Gene
LBRM_11_0850  putative pretranslocation protein, alpha subunit [KO:K10956]
LBRM_25_0900  putative protein transport protein Sec61 gamma subunit [KO:K07342]
LBRM_34_4610  conserved hypothetical protein [KO:K09540]
LBRM_34_1050  oligosaccharyl transferase-like protein [KO:K07151] [EC:2.4.99.18]
LBRM_34_1060  oligosaccharyl transferase-like protein [KO:K07151] [EC:2.4.99.18]
LBRM_34_1070  putative oligosaccharyl transferase subunit [KO:K07151] [EC:2.4.99.18]
LBRM_27_0430  oligosaccharyl transferase-like protein [KO:K07151] [EC:2.4.99.18]
LBRM_28_2400  conserved hypothetical protein [KO:K01228] [EC:3.2.1.106]
LBRM_28_1300  putative glucose-regulated protein 78 [KO:K09490] [EC:3.6.4.10]
LBRM_14_1500  conserved hypothetical protein [KO:K09523]
LBRM_18_0110  putative alpha glucosidase II subunit [KO:K05546] [EC:3.2.1.207]
LBRM_26_1010  conserved hypothetical protein [KO:K08288]
LBRM_31_2940  putative calreticulin [KO:K08057]
LBRM_13_0490  putative lectin [KO:K10080]
LBRM_05_0030  putative ras-like small GTPases [KO:K07953] [EC:3.6.5.-]
LBRM_32_0100  putative protein transport protein Sec13 [KO:K14004]
LBRM_11_0920  putative protein transport protein Sec31 [KO:K14005]
LBRM_35_6760  protein transport protein Sec23-like protein [KO:K14006]
LBRM_25_1040  putative protein transport protein Sec24C [KO:K14007]
LBRM_29_2090  conserved hypothetical protein [KO:K11718] [EC:2.4.1.-]
LBRM_20_1700  conserved hypothetical protein [KO:K09584] [EC:5.3.4.1]
LBRM_26_0670  putative protein disulfide isomerase [KO:K09584] [EC:5.3.4.1]
LBRM_22_0250  conserved hypothetical protein [KO:K13249]
LBRM_33_2060  conserved hypothetical protein [KO:K13989]
LBRM_19_0440  conserved hypothetical protein [KO:K13989]
LBRM_35_1490  putative transitional endoplasmic reticulum ATPase [KO:K13525]
LBRM_25_1250  conserved hypothetical protein [KO:K14015]
LBRM_35_6830  putative ubiquitin fusion degradation protein [KO:K14016]
LBRM_35_6940  putative ubiquitin fusion degradation protein [KO:K14016]
LBRM_28_3030  putative heat shock protein 70 [KO:K03283]
LBRM_26_1260  heat shock protein 70-related protein [KO:K03283]
LBRM_28_2990  putative heat-shock protein hsp70 [KO:K03283]
LBRM_27_2610  putative heat shock protein DNAJ [KO:K09503]
LBRM_35_2340  conserved hypothetical protein [KO:K09518]
LBRM_33_0340  heat shock protein 83-1 [KO:K04079]
LBRM_33_0330  HSP83; heat shock protein 83-1 [KO:K04079]
LBRM_33_0350  HSP83; heat shock protein 83-1 [KO:K04079]
LBRM_29_2420  putative heat shock protein 20 [KO:K13993]
LBRM_35_6330  conserved hypothetical protein [KO:K13719] [EC:3.1.2.-]
LBRM_24_1970  conserved hypothetical protein [KO:K14018]
LBRM_30_3340  UV excision repair RAD23-like protein [KO:K10839]
LBRM_35_0650  putative ubiquitin-like protein [KO:K04523]
LBRM_03_0890  putative elongation initiation factor 2 alpha subunit [KO:K03237]
LBRM_20_0870  putative ubiquitin-conjugating enzyme E2 [KO:K04554] [EC:2.3.2.23]
LBRM_20_0890  putative ubiquitin-conjugating enzyme E2 [KO:K04554] [EC:2.3.2.23]
LBRM_20_0900  putative ubiquitin-conjugating enzyme E2 [KO:K04554] [EC:2.3.2.23]
LBRM_15_1410  conserved hypothetical protein [KO:K10601] [EC:2.3.2.27]
LBRM_34_1220  putative ubiquitin-conjugating enzyme E2 [KO:K06689] [EC:2.3.2.23]
LBRM_21_0040  putative ring-box protein 1 [KO:K03868] [EC:2.3.2.32]
LBRM_24_1670  putative ring-box protein [KO:K03868] [EC:2.3.2.32]
LBRM_11_0950  Cyclin A/CDK2-associated protein [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
lbz00510  N-Glycan biosynthesis
lbz03050  Proteasome
lbz03060  Protein export
KO pathway
ko04141   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (51)   
   KEGG GENES (51)   
All databases (52)   

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