KEGG   PATHWAY: ldo00630
Entry
ldo00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Leishmania donovani
Class
Metabolism; Carbohydrate metabolism
Pathway map
ldo00630  Glyoxylate and dicarboxylate metabolism
ldo00630

Module
ldo_M00621  Glycine cleavage system [PATH:ldo00630]
ldo_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:ldo00630]
Other DBs
GO: 0046487 0043648
Organism
Leishmania donovani [GN:ldo]
Gene
LDBPK_230580  acetyl-CoA synthetase, putative [KO:K01895] [EC:6.2.1.1]
LDBPK_283090  cytosolic malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
LDBPK_340140  malate dehydrogenase, putative [KO:K00026] [EC:1.1.1.37]
LDBPK_340150  malate dehydrogenase [KO:K00026] [EC:1.1.1.37]
LDBPK_340160  malate dehydrogenase, putative [KO:K00026] [EC:1.1.1.37]
LDBPK_340170  mitochondrial malate dehydrogenase [KO:K00026] [EC:1.1.1.37]
LDBPK_190710  glycosomal malate dehydrogenase [KO:K00026] [EC:1.1.1.37]
LDBPK_180700  citrate synthase, putative [KO:K01647] [EC:2.3.3.1]
LDBPK_180510  aconitase, putative [KO:K01681] [EC:4.2.1.3]
LDBPK_260030  methylmalonyl-coa epimerase-like protein [KO:K05606] [EC:5.1.99.1]
LDBPK_010050  carboxylase, putative [KO:K01965] [EC:6.4.1.3]
LDBPK_280260  propionyl-coa carboxylase beta chain, putative [KO:K01966] [EC:6.4.1.3 2.1.3.15]
LDBPK_280250  propionyl-coa carboxylase beta chain, putative [KO:K01966] [EC:6.4.1.3 2.1.3.15]
LDBPK_270310  methylmalonyl-coenzyme a mutase, putative [KO:K01847] [EC:5.4.99.2]
LDBPK_060370  glutamine synthetase, putative [KO:K01915] [EC:6.3.1.2]
LDBPK_282530  serine hydroxymethyltransferase (SHMT-L) [KO:K00600] [EC:2.1.2.1]
LDBPK_141400  serine hydroxymethyltranferase (SHMT-S) [KO:K00600] [EC:2.1.2.1]
LDBPK_260040  glycine dehydrogenase, putative [KO:K00281] [EC:1.4.4.2]
LDBPK_364000  aminomethyltransferase, mitochondrial precursor, putative [KO:K00605] [EC:2.1.2.10]
LDBPK_323510  dihydrolipoamide dehydrogenase, putative [KO:K00382] [EC:1.8.1.4]
LDBPK_312710  2-oxoglutarate dehydrogenase, E3 component, lipoamidedehydrogenase-like protein [KO:K00382] [EC:1.8.1.4]
LDBPK_312720  acetoin dehydrogenase E3 component-like protein [KO:K00382] [EC:1.8.1.4]
LDBPK_291950  dihydrolipoamide dehydrogenase, putative [KO:K00382] [EC:1.8.1.4]
LDBPK_354790  glycine cleavage system H protein, putative [KO:K02437]
LDBPK_300170  2-hydroxy-3-oxopropionate reductase, putative [KO:K00042] [EC:1.1.1.60]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
ldo00010  Glycolysis / Gluconeogenesis
ldo00020  Citrate cycle (TCA cycle)
ldo00030  Pentose phosphate pathway
ldo00053  Ascorbate and aldarate metabolism
ldo00071  Fatty acid degradation
ldo00230  Purine metabolism
ldo00250  Alanine, aspartate and glutamate metabolism
ldo00260  Glycine, serine and threonine metabolism
ldo00620  Pyruvate metabolism
ldo00750  Vitamin B6 metabolism
ldo00910  Nitrogen metabolism
KO pathway
ko00630   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG GENES (25)   
All databases (26)   

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