KEGG   PATHWAY: ldo03013
Entry
ldo03013                    Pathway                                
Name
Nucleocytoplasmic transport - Leishmania donovani
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
ldo03013  Nucleocytoplasmic transport
ldo03013

Other DBs
GO: 0050658
Organism
Leishmania donovani [GN:ldo]
Gene
LDBPK_010330  poly(A) export protein, putative [KO:K14298]
LDBPK_270390  nucleoporin, putative [KO:K14297]
LDBPK_020360  ubiquitin-conjugating enzyme E2, putative [KO:K10577]
LDBPK_320050  protein transport protein Sec13, putative [KO:K14004]
LDBPK_322530  hypothetical protein [KO:K14306]
LDBPK_367220  nuclear pore complex protein (NUP155), putative [KO:K14312]
LDBPK_301180  importin alpha, putative [KO:K15042]
LDBPK_340510  importin beta-1 subunit, putative [KO:K14293]
LDBPK_352380  hypothetical protein [KO:K18727]
LDBPK_070810  hypothetical protein [KO:K20221]
LDBPK_322280  hypothetical protein [KO:K20222]
LDBPK_130530  hypothetical protein [KO:K20223]
LDBPK_292180  hypothetical protein [KO:K20223]
LDBPK_321160  exportin 1, putative [KO:K14290]
LDBPK_303440  CAS/CSE/importin domain protein, putative [KO:K18423]
LDBPK_020090  exportin T (tRNA exportin)-like protein [KO:K14288]
LDBPK_101300  hypothetical protein [KO:K18460]
LDBPK_251460  GTP-binding protein, putative [KO:K07936]
LDBPK_170170  elongation factor 1-alpha [KO:K03231]
LDBPK_300560  nuclear cap binding protein, putative [KO:K12883]
LDBPK_260940  hypothetical protein [KO:K07562]
LDBPK_260750  hypothetical protein [KO:K12876]
LDBPK_303620  mago nashi-like protein,putative [KO:K12877]
LDBPK_281660  DEAD box RNA helicase, putative [KO:K13025] [EC:5.6.2.7]
LDBPK_271590  hypothetical protein [KO:K14284]
LDBPK_061210  nuclear transport factor 2 protein(NFT2), putative [KO:K14285]
LDBPK_211820  RNA helicase, putative [KO:K12812] [EC:5.6.2.7]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
ldo03015  mRNA surveillance pathway
KO pathway
ko03013   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG GENES (27)   
All databases (28)   

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