KEGG   PATHWAY: ldo04141
Entry
ldo04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Leishmania donovani
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ldo04141  Protein processing in endoplasmic reticulum
ldo04141

Other DBs
GO: 0030433 0034976
Organism
Leishmania donovani [GN:ldo]
Gene
LDBPK_111050  pretranslocation protein, alpha subunit, putative [KO:K10956]
LDBPK_251050  protein transport protein Sec61 gamma subunit, putative [KO:K07342]
LDBPK_354700  hypothetical protein [KO:K09540]
LDBPK_351160  oligosaccharyl transferase-like protein [KO:K07151] [EC:2.4.99.18]
LDBPK_282350  hypothetical protein [KO:K01228] [EC:3.2.1.106]
LDBPK_281310  glucose-regulated protein 78, putative [KO:K09490] [EC:3.6.4.10]
LDBPK_141410  hypothetical protein [KO:K09523]
LDBPK_180090  alpha glucosidase II subunit, putative [KO:K05546] [EC:3.2.1.207]
LDBPK_260970  hypothetical protein [KO:K08288]
LDBPK_312670  calreticulin, putative [KO:K08057]
LDBPK_130560  lectin, putative [KO:K10080]
LDBPK_050030  ras-like small GTPases, putative [KO:K07953] [EC:3.6.5.-]
LDBPK_320050  protein transport protein Sec13, putative [KO:K14004]
LDBPK_111140  protein transport protein Sec31, putative [KO:K14005]
LDBPK_111150  protein transport protein Sec31, putative [KO:K14005]
LDBPK_366710  protein transport protein Sec23-like protein [KO:K14006]
LDBPK_251380  protein transport protein Sec24C, putative [KO:K14007]
LDBPK_292230  hypothetical protein [KO:K11718] [EC:2.4.1.-]
LDBPK_260630  protein disulfide isomerase, putative [KO:K09584] [EC:5.3.4.1]
LDBPK_341960  hypothetical protein [KO:K09584] [EC:5.3.4.1]
LDBPK_220130  hypothetical protein [KO:K13249]
LDBPK_331900  hypothetical protein [KO:K13989]
LDBPK_190120  hypothetical protein [KO:K13989]
LDBPK_361420  Transitional endoplasmic reticulum ATPase, putative [KO:K13525]
LDBPK_251320  hypothetical protein [KO:K14015]
LDBPK_366780  ubiquitin fusion degradation protein, putative [KO:K14016]
LDBPK_283000  heat-shock protein hsp70, putative [KO:K03283]
LDBPK_283040  heat shock protein 70, putative [KO:K03283]
LDBPK_261220  heat shock protein 70-related protein [KO:K03283]
LDBPK_210550  DnaJ protein, putative [KO:K09503]
LDBPK_272350  heat shock protein DNAJ, putative [KO:K09503]
LDBPK_362230  hypothetical protein [KO:K09518]
LDBPK_330360  heat shock protein 83-1 [KO:K04079]
LDBPK_330370  heat shock protein 83-1 [KO:K04079]
LDBPK_330350  heat shock protein 83-1 [KO:K04079]
LDBPK_292560  heat shock protein 20, putative [KO:K13993]
LDBPK_366280  hypothetical protein [KO:K13719] [EC:3.1.2.-]
LDBPK_241970  hypothetical protein [KO:K14018]
LDBPK_303350  UV excision repair RAD23-like protein [KO:K10839]
LDBPK_360590  ubiquitin-like protein, putative [KO:K04523]
LDBPK_030960  elongation initiation factor 2 alpha subunit, putative [KO:K03237]
LDBPK_340950  ubiquitin-conjugating enzyme E2, putative [KO:K04554] [EC:2.3.2.23]
LDBPK_151460  hypothetical protein [KO:K10601] [EC:2.3.2.27]
LDBPK_351310  ubiquitin-conjugating enzyme E2, putative [KO:K06689] [EC:2.3.2.23]
LDBPK_210040  ring-box protein 1, putative [KO:K03868] [EC:2.3.2.32]
LDBPK_241680  ring-box protein, putative [KO:K03868] [EC:2.3.2.32]
LDBPK_111200  S-phase kinase-associated protein, putative [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
ldo00510  N-Glycan biosynthesis
ldo03050  Proteasome
ldo03060  Protein export
KO pathway
ko04141   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (47)   
   KEGG GENES (47)   
All databases (48)   

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