KEGG   PATHWAY: lif04146
Entry
lif04146                    Pathway                                
Name
Peroxisome - Leishmania infantum
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
lif04146  Peroxisome
lif04146

Other DBs
GO: 0005777
Organism
Leishmania infantum [GN:lif]
Gene
LINJ_35_3310  Peroxin 19 [KO:K13337]
LINJ_33_1960  ATP-binding cassette protein subfamily D, member 3 [KO:K05677] [EC:7.6.2.4]
LINJ_29_0770  putative peroxisomal targeting signal type 2 receptor [KO:K13341]
LINJ_35_1430  putative peroxisome targeting signal 1 receptor [KO:K13342]
LINJ_21_2210  PEX14; putative peroxin 14 [KO:K13343]
LINJ_19_1240  putative peroxisome assembly protein [KO:K13345]
LINJ_25_2400  conserved hypothetical protein [KO:K13346]
LINJ_25_2330  PEX2; glycosome import protein [KO:K06664]
LINJ_01_0510  putative long-chain-fatty-acid-CoA ligase [KO:K01897] [EC:6.2.1.3]
LINJ_03_0220  putative long chain fatty Acyl CoA synthetase [KO:K01897] [EC:6.2.1.3]
LINJ_01_0540  putative long-chain-fatty-acid-CoA ligase [KO:K01897] [EC:6.2.1.3]
LINJ_01_0490  putative fatty acyl CoA syntetase 1 [KO:K01897] [EC:6.2.1.3]
LINJ_01_0520  putative fatty acyl CoA synthetase 2 [KO:K01897] [EC:6.2.1.3]
LINJ_13_0300  putative acyl-CoA synthetase [KO:K01897] [EC:6.2.1.3]
LINJ_01_0550  putative long-chain-fatty-acid-CoA ligase [KO:K01897] [EC:6.2.1.3]
LINJ_07_0820  malonyl-coa decarboxylase-like protein [KO:K01578] [EC:4.1.1.9]
LINJ_34_1170  DAT; dihydroxyacetonephosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
LINJ_30_0120  ADS1; alkyldihydroxyacetonephosphate synthase [KO:K00803] [EC:2.5.1.26]
LINJ_24_1710  conserved hypothetical protein [KO:K13356] [EC:1.2.1.84]
LINJ_31_0580  putative mevalonate kinase [KO:K00869] [EC:2.7.1.36]
LINJ_33_2680  putative isocitrate dehydrogenase [KO:K00031] [EC:1.1.1.42]
LINJ_10_0310  putative isocitrate dehydrogenase [NADP], mitochondrial precursor [KO:K00031] [EC:1.1.1.42]
LINJ_32_1910  SODB1; putative iron superoxide dismutase [KO:K04564] [EC:1.15.1.1]
LINJ_32_1920  SODB2; putative iron superoxide dismutase [KO:K04564] [EC:1.15.1.1]
LINJ_30_2780  putative superoxide dismutase [KO:K04564] [EC:1.15.1.1]
LINJ_08_0300  FESODA; iron superoxide dismutase [KO:K04564] [EC:1.15.1.1]
LINJ_32_2770  putative superoxide dismutase [KO:K04564] [EC:1.15.1.1]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
lif00071  Fatty acid degradation
lif00230  Purine metabolism
lif00564  Glycerophospholipid metabolism
lif00565  Ether lipid metabolism
lif00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG GENES (27)   
All databases (28)   

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