KEGG   PATHWAY: lma03420
Entry
lma03420                    Pathway                                
Name
Nucleotide excision repair - Leishmania major
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
lma03420  Nucleotide excision repair
lma03420

Other DBs
GO: 0006289
Organism
Leishmania major [GN:lma]
Gene
LMJF_21_0023  putative ring-box protein 1 [KO:K03868] [EC:2.3.2.32]
LMJF_24_1610  putative ring-box protein [KO:K03868] [EC:2.3.2.32]
LMJF_35_3450  putative DNA-repair protein [KO:K10838]
LMJF_30_3300  UV excision repair RAD23-like protein [KO:K10839]
LMJF_14_0840  putative DNA excision repair protein [KO:K10841]
LMJF_31_2610  RPOIILS; RNA polymerase II largest subunit [KO:K03006] [EC:2.7.7.6]
LMJF_31_0160  putative DNA-directed RNA polymerase II subunit 2 [KO:K03010] [EC:2.7.7.6]
LMJF_29_0140  DNA-directed RNA polymerase I-like protein [KO:K03011]
LMJF_18_0780  putative DNA-directed RNA polymerases II [KO:K03013]
LMJF_34_0890  putative DNA-directed RNA polymerase subunit [KO:K03014]
LMJF_32_1280  putative RNA polymerase-like protein [KO:K03015]
LMJF_28_0810  putative RNA polymerase B subunit RPB8 [KO:K03016]
LMJF_28_0120  putative DNA-direcetd RNA polymerase II,subunit 9 [KO:K03017]
LMJF_13_1120  putative DNA-directed RNA polymerase II 8.2 Kdpolypeptide [KO:K03007]
LMJF_25_1315  DNA-directed RNA polymerase II [KO:K03007]
LMJF_27_1550  DNA-directed RNA polymerase II-like protein [KO:K03008]
LMJF_32_3920  putative DNA repair helicase [KO:K10843] [EC:5.6.2.4]
LMJF_24_2280  putative DNA excision repair protein [KO:K10844] [EC:5.6.2.3]
LMJF_24_1680  hypothetical protein [KO:K03142]
LMJF_36_0800  hypothetical protein [KO:K03144]
LMJF_35_3590  putative DNA repair protein RAD2 [KO:K10846]
LMJF_28_1820  RPA1; putative replication factor A, 51kDa subunit [KO:K07466]
LMJF_15_0270  putative replication Factor A 28 kDa subunit [KO:K10739]
LMJF_08_0140  putative DNA repair protein [KO:K10848] [EC:3.1.-.-]
LMJF_33_1690  putative DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
LMJF_25_1410  putative DNA polymerase delta subunit 2 [KO:K02328]
LMJF_35_4360  putative DNA polymerase epsilon catalytic subunit [KO:K02324] [EC:2.7.7.7]
LMJF_35_1790  putative DNA polymerase epsilon subunit B [KO:K02325] [EC:2.7.7.7]
LMJF_15_1450  putative proliferative cell nuclear antigen (PCNA) [KO:K04802]
LMJF_24_0990  putative replication factor C, subunit 1 [KO:K10754]
LMJF_30_2630  putative replication factor C, subunit 2 [KO:K10755]
LMJF_27_0550  putative replication factor C, subunit 4 [KO:K10755]
LMJF_36_6710  putative replication factor C, subunit 5 [KO:K10756]
LMJF_35_3250  putative replication factor C, subunit 3 [KO:K10756]
LMJF_30_3440  putative DNA ligase I [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
lma03020  RNA polymerase
lma04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (35)   
   KEGG GENES (35)   
All databases (36)   

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