KEGG   PATHWAY: lma04145Help
Entry
lma04145                    Pathway                                

Name
Phagosome - Leishmania major
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
lma04145  Phagosome
lma04145

Ortholog table
Other DBs
GO: 0045335
Organism
Leishmania major [GN:lma]
Gene
LMJF_19_0400  putative Qc-SNARE protein [KO:K08517]
LMJF_13_0220  putative small Rab GTP binding protein [KO:K07889]
LMJF_20_1120  putative phosphatidylinositol 3-kinase [KO:K00914] [EC:2.7.1.137]
LMJF_24_2010  putative phosphatidylinositol 3-kinase [KO:K00914] [EC:2.7.1.137]
LMJF_34_3670  putative vacuolar ATP synthase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
LMJF_28_2430  putative vacuolar ATP synthase subunit B [KO:K02147]
LMJF_18_0560  putative vacuolar ATP synthase subunit C [KO:K02148]
LMJF_35_0700  putative vacuolar ATP synthase subunit D [KO:K02149]
LMJF_36_3100  putative ATP synthase [KO:K02150]
LMJF_12_0520  putative vacuolar ATP synthase subunit [KO:K02151]
LMJF_23_0340  putative (H+)-ATPase G subunit [KO:K02152]
LMJF_28_0640  hypothetical protein [KO:K02153]
LMJF_23_1510  putative vacuolar proton translocating ATPase subunit A [KO:K02154]
LMJF_32_0920  putative vacuolar proton-ATPase-like protein [KO:K02154]
LMJF_05_1140  vacuolar ATPase subunit-like protein [KO:K02146]
LMJF_21_1340  putative ATP synthase [KO:K02144]
LMJF_21_1790  putative vacuolar ATP synthase [KO:K02155]
LMJF_21_1800  putative vacuolar ATP synthase [KO:K02155]
LMJF_28_1160  putative vacuolar type h+ ATPase subunit [KO:K02155]
LMJF_23_0130  putative vacuolar type h+ ATPase subunit [KO:K02155]
LMJF_30_3660  putative V-type ATPase, C subunit [KO:K03661]
LMJF_18_0890  RAB7; putative rab7 GTP binding protein [KO:K07897]
LMJF_22_1110  putative dynein heavy chain, cytosolic [KO:K10413]
LMJF_34_4160  putative dynein heavy chain [KO:K10414]
LMJF_27_1750  putative dynein heavy chain [KO:K10414]
LMJF_13_0390  alpha tubulin [KO:K07374]
LMJF_13_0380  alpha tubulin [KO:K07374]
LMJF_13_0370  alpha tubulin [KO:K07374]
LMJF_13_0290  alpha tubulin [KO:K07374]
LMJF_13_0360  alpha tubulin [KO:K07374]
LMJF_13_0280  alpha tubulin [KO:K07374]
LMJF_13_0350  alpha tubulin [KO:K07374]
LMJF_13_0340  alpha tubulin [KO:K07374]
LMJF_13_0330  alpha tubulin [KO:K07374]
LMJF_13_0320  alpha tubulin [KO:K07374]
LMJF_13_0310  alpha tubulin [KO:K07374]
LMJF_13_0300  alpha tubulin [KO:K07374]
LMJF_21_1860  beta tubulin [KO:K07375]
LMJF_33_0792  beta tubulin [KO:K07375]
LMJF_33_0794  beta tubulin [KO:K07375]
LMJF_33_0796  beta tubulin [KO:K07375]
LMJF_33_0798  beta tubulin [KO:K07375]
LMJF_08_1230  beta tubulin [KO:K07375]
LMJF_33_0820  beta tubulin [KO:K07375]
LMJF_33_0810  beta tubulin [KO:K07375]
LMJF_33_0812  beta tubulin [KO:K07375]
LMJF_33_0814  beta tubulin [KO:K07375]
LMJF_33_0816  beta tubulin [KO:K07375]
LMJF_33_0818  beta tubulin [KO:K07375]
LMJF_33_0819  beta tubulin [KO:K07375]
LMJF_33_0800  beta tubulin [KO:K07375]
LMJF_33_0802  beta tubulin [KO:K07375]
LMJF_33_0804  beta tubulin [KO:K07375]
LMJF_33_0806  beta tubulin [KO:K07375]
LMJF_33_0808  beta tubulin [KO:K07375]
LMJF_11_1050  putative pretranslocation protein,alpha subunit [KO:K10956]
LMJF_25_1015  putative protein transport protein Sec61 gamma subunit [KO:K07342]
LMJF_31_2600  putative calreticulin [KO:K08057]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
KO pathway
ko04145   

DBGET integrated database retrieval system