KEGG   PATHWAY: loa03013
Entry
loa03013                    Pathway                                
Name
Nucleocytoplasmic transport - Loa loa (eye worm)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
loa03013  Nucleocytoplasmic transport
loa03013

Other DBs
GO: 0050658
Organism
Loa loa (eye worm) [GN:loa]
Gene
LOAG_08284  hypothetical protein [KO:K14320]
LOAG_06510  hypothetical protein [KO:K18655] [EC:5.6.2.7]
LOAG_06150  nucleoporin-17 [KO:K14298]
LOAG_04654  hypothetical protein [KO:K14297]
LOAG_00114  hypothetical protein [KO:K14317]
LOAG_17733  hypothetical protein [KO:K14318]
LOAG_18036  leucine Rich Repeat family protein [KO:K14319]
LOAG_05393  SUMO-conjugating enzyme UBC9 [KO:K10577]
LOAG_01479  SMO-1 protein [KO:K12160]
LOAG_06232  hypothetical protein [KO:K14303]
LOAG_13383  hypothetical protein [KO:K14304]
LOAG_17130  WD-40 repeat protein, variant [KO:K14004]
LOAG_02422  hypothetical protein [KO:K14301]
LOAG_02039  hypothetical protein [KO:K14300]
LOAG_03475  hypothetical protein [KO:K14299]
LOAG_01143  hypothetical protein [KO:K14305]
LOAG_10945  hypothetical protein [KO:K25129]
LOAG_18160  nuclear pore protein [KO:K14306]
LOAG_05514  hypothetical protein [KO:K14307]
LOAG_04523  hypothetical protein [KO:K14308]
LOAG_16991  hypothetical protein [KO:K14310]
LOAG_16990  hypothetical protein [KO:K14310]
LOAG_00466  hypothetical protein [KO:K14312]
LOAG_18149  nucleoporin interacting component family protein [KO:K14309]
LOAG_10395  hypothetical protein [KO:K14313]
LOAG_05335  hypothetical protein [KO:K14315]
LOAG_17647  nuclear pore complex protein 12 [KO:K14314]
LOAG_04408  membrane protein [KO:K20724]
LOAG_18641  viral A-type inclusion protein repeat containing protein [KO:K09291]
LOAG_04583  hypothetical protein [KO:K14295]
LOAG_04071  hypothetical protein [KO:K14296]
LOAG_01546  hypothetical protein [KO:K23583]
LOAG_01346  importin alpha-3 subunit [KO:K23583]
LOAG_12938  karyopherin alpha [KO:K15042]
LOAG_07693  hypothetical protein [KO:K15042]
LOAG_04985  hypothetical protein [KO:K14293]
LOAG_16994  importin-beta domain-containing protein [KO:K18752]
LOAG_04608  transportin-SR [KO:K15436]
LOAG_01323  kap beta 3 protein [KO:K20222]
LOAG_18897  importin-beta domain-containing protein [KO:K20223]
LOAG_18230  importin-beta domain-containing protein [KO:K14290]
LOAG_04783  importin beta family protein 5 [KO:K18423]
LOAG_18761  importin beta family protein 6 [KO:K14288]
LOAG_17920  hypothetical protein [KO:K25203]
LOAG_02539  hypothetical protein [KO:K14289]
LOAG_17636  exportin-7 [KO:K18460]
LOAG_08002  GTP-binding nuclear protein RAN/TC4 [KO:K07936]
LOAG_08753  elongation factor 1-alpha [KO:K03231]
LOAG_06320  elongation factor 1-alpha [KO:K03231]
LOAG_05382  hypothetical protein [KO:K14291]
LOAG_06484  hypothetical protein [KO:K12882]
LOAG_16677  MIF4G domain-containing protein [KO:K12882]
LOAG_03270  nuclear cap binding protein subunit 2 [KO:K12883]
LOAG_02499  NMD3 family protein [KO:K07562]
LOAG_16958  hypothetical protein [KO:K12876]
LOAG_08619  mago nashi protein [KO:K12877]
LOAG_08899  hypothetical protein [KO:K14323]
LOAG_07474  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
LOAG_02896  hypothetical protein [KO:K12875]
LOAG_05794  hypothetical protein [KO:K14324]
LOAG_17528  hypothetical protein [KO:K14325]
LOAG_05613  hypothetical protein [KO:K13114]
LOAG_06665  RNA binding protein [KO:K12881]
LOAG_03885  RNA and export factor binding protein 2 [KO:K12881]
LOAG_03249  nonsense mRNA reducing factor 1 NORF1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
LOAG_02196  hypothetical protein [KO:K14327]
LOAG_05102  hypothetical protein [KO:K14328]
LOAG_09100  hypothetical protein [KO:K14284]
LOAG_04847  hypothetical protein, variant 2 [KO:K14285]
LOAG_18422  spliceosome RNA helicase BAT1 [KO:K12812] [EC:5.6.2.7]
LOAG_00129  PWI domain-containing protein [KO:K13171]
LOAG_15159  within the bgcn intron protein [KO:K14294]
LOAG_00915  hypothetical protein [KO:K12878]
LOAG_17756  tho complex subunit protein 2 [KO:K12879]
LOAG_16461  fms interacting protein [KO:K13174]
LOAG_12846  hypothetical protein [KO:K13175]
LOAG_10082  hypothetical protein [KO:K13176]
LOAG_06034  hypothetical protein [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
loa03015  mRNA surveillance pathway
KO pathway
ko03013   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (78)   
   KEGG GENES (78)   
All databases (79)   

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