KEGG PATHWAY: map04216

PATHWAY: map04216

Entry

map04216                    Pathway

Name

Ferroptosis

Description

Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer cell and certain normal cells. It is involved in multiple physiological and pathological processes, such as cancer cell death, neurodegenerative disease, tissue damage and acute renal failure.

Class

Cellular Processes; Cell growth and death

Pathway map

map04216

Ferroptosis

Other DBs

GO:

0097707

Reference

PMID:26775689

Authors

Conrad M, Angeli JP, Vandenabeele P, Stockwell BR

Title

Regulated necrosis: disease relevance and therapeutic opportunities.

Journal

Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6

Reference

PMID:26653790

Authors

Yang WS, Stockwell BR

Title

Ferroptosis: Death by Lipid Peroxidation.

Journal

Trends Cell Biol 26:165-76 (2016)
DOI:10.1016/j.tcb.2015.10.014

Reference

PMID:27842066

Authors

Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayir H

Title

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.

Journal

Nat Chem Biol 13:81-90 (2017)
DOI:10.1038/nchembio.2238

Reference

PMID:27842067

Authors

D'Herde K, Krysko DV

Title

Ferroptosis: Oxidized PEs trigger death.

Journal

Nat Chem Biol 13:4-5 (2017)
DOI:10.1038/nchembio.2261

Reference

PMID:28082232

Authors

Guiney SJ, Adlard PA, Bush AI, Finkelstein DI, Ayton S

Title

Ferroptosis and cell death mechanisms in Parkinson's disease.

Journal

Neurochem Int 104:34-48 (2017)
DOI:10.1016/j.neuint.2017.01.004

Reference

PMID:26725301

Authors

Bogdan AR, Miyazawa M, Hashimoto K, Tsuji Y

Title

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease.

Journal

Trends Biochem Sci 41:274-86 (2016)
DOI:10.1016/j.tibs.2015.11.012

Reference

PMID:26794443

Authors

Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, Kang R, Tang D

Title

Ferroptosis: process and function.

Journal

Cell Death Differ 23:369-79 (2016)
DOI:10.1038/cdd.2015.158

Reference

PMID:27791175

Authors

Murphy ME

Title

Ironing out how p53 regulates ferroptosis.

Journal

Proc Natl Acad Sci U S A 113:12350-12352 (2016)
DOI:10.1073/pnas.1615159113

Reference

PMID:28129536

Authors

Muckenthaler MU, Rivella S, Hentze MW, Galy B

Title

A Red Carpet for Iron Metabolism.

Journal

Cell 168:344-361 (2017)
DOI:10.1016/j.cell.2016.12.034

Reference

PMID:27860262

Authors

Yu H, Guo P, Xie X, Wang Y, Chen G

Title

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases.

Journal

J Cell Mol Med 21:648-657 (2017)
DOI:10.1111/jcmm.13008

Reference

PMID:27314071

Authors

Wang SJ, Ou Y, Jiang L, Gu W

Title

Ferroptosis: A missing puzzle piece in the p53 blueprint?

Journal

Mol Cell Oncol 3:e1046581 (2016)
DOI:10.1080/23723556.2015.1046581

Reference

PMID:27048822

Authors

Cao JY, Dixon SJ

Title

Mechanisms of ferroptosis.

Journal

Cell Mol Life Sci 73:2195-209 (2016)
DOI:10.1007/s00018-016-2194-1

Reference

PMID:26436293

Authors

Mancias JD, Pontano Vaites L, Nissim S, Biancur DE, Kim AJ, Wang X, Liu Y, Goessling W, Kimmelman AC, Harper JW

Title

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.

Journal

Elife 4:e10308 (2015)
DOI:10.7554/eLife.10308

Reference

PMID:28066232

Authors

Wang YQ, Chang SY, Wu Q, Gou YJ, Jia L, Cui YM, Yu P, Shi ZH, Wu WS, Gao G, Chang YZ

Title

The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis.

Journal

Front Aging Neurosci 8:308 (2016)
DOI:10.3389/fnagi.2016.00308

Reference

PMID:26405158

Authors

Kwon MY, Park E, Lee SJ, Chung SW

Title

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death.

Journal

Oncotarget 6:24393-403 (2015)
DOI:10.18632/oncotarget.5162

Reference

PMID:22632964

Authors

Reed JC, Pellecchia M

Title

Ironing out cell death mechanisms.

Journal

Cell 149:963-5 (2012)
DOI:10.1016/j.cell.2012.05.009

Related
pathway

map00480

Glutathione metabolism

map00900

Terpenoid backbone biosynthesis

KO pathway

ko04216

All links

Drug (2)   
   KEGG DRUG (2)   
Chemical substance (29)   
   KEGG COMPOUND (29)   
Gene (117161)   
   KEGG ORTHOLOGY (33)   
   RefGene (117128)   
Literature (16)   
   PubMed (16)   
All databases (117208)   

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