KEGG   PATHWAY: map04978
Entry
map04978                    Pathway                                
Name
Mineral absorption
Description
Minerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an intracellular messenger in muscle contraction/relaxation, neural networks, the immune system, and endocrine/exocrine cells. Iron, copper, and other metals are required for redox reactions (as cofactors) and for oxygen transport and binding (in hemoglobin and myoglobin). Many enzymes require specific metal atoms to complete their catalytic functions. Animal tissues need moderate quantities of some elements (Ca, P, K, Na, Mg, S, and Cl) and trace amounts of others (Mn, Fe, I, Co, Cr, Cu, Zn, and Se). The minerals are absorbed by either passive or active transport systems through the intestinal mucosa, often using specialized transport proteins, such as ferritin for Fe3+ and vitamin D-induced protein for calcium.
Class
Organismal Systems; Digestive system
Pathway map
map04978  Mineral absorption
map04978

Reference
  Authors
Perez AV, Picotto G, Carpentieri AR, Rivoira MA, Peralta Lopez ME, Tolosa de Talamoni NG
  Title
Minireview on regulation of intestinal calcium absorption. Emphasis on molecular mechanisms of transcellular pathway.
  Journal
Digestion 77:22-34 (2008)
DOI:10.1159/000116623
Reference
  Authors
Khanal RC, Nemere I
  Title
Regulation of intestinal calcium transport.
  Journal
Annu Rev Nutr 28:179-96 (2008)
DOI:10.1146/annurev.nutr.010308.161202
Reference
  Authors
Hoenderop JG, Nilius B, Bindels RJ
  Title
Calcium absorption across epithelia.
  Journal
Physiol Rev 85:373-422 (2005)
DOI:10.1152/physrev.00003.2004
Reference
  Authors
Bouillon R, Van Cromphaut S, Carmeliet G
  Title
Intestinal calcium absorption: Molecular vitamin D mediated mechanisms.
  Journal
J Cell Biochem 88:332-9 (2003)
DOI:10.1002/jcb.10360
Reference
  Authors
Chua AC, Graham RM, Trinder D, Olynyk JK
  Title
The regulation of cellular iron metabolism.
  Journal
Crit Rev Clin Lab Sci 44:413-59 (2007)
DOI:10.1080/10408360701428257
Reference
  Authors
West AR, Oates PS
  Title
Mechanisms of heme iron absorption: current questions and controversies.
  Journal
World J Gastroenterol 14:4101-10 (2008)
DOI:10.3748/wjg.14.4101
Reference
  Authors
Dunn LL, Rahmanto YS, Richardson DR
  Title
Iron uptake and metabolism in the new millennium.
  Journal
Trends Cell Biol 17:93-100 (2007)
DOI:10.1016/j.tcb.2006.12.003
Reference
  Authors
Donovan A, Roy CN, Andrews NC
  Title
The ins and outs of iron homeostasis.
  Journal
Physiology (Bethesda) 21:115-23 (2006)
DOI:10.1152/physiol.00052.2005
Reference
  Authors
Lonnerdal B
  Title
Intestinal regulation of copper homeostasis: a developmental perspective.
  Journal
Am J Clin Nutr 88:846S-50S (2008)
DOI:10.1093/ajcn/88.3.846S
Reference
  Authors
Prohaska JR
  Title
Role of copper transporters in copper homeostasis.
  Journal
Am J Clin Nutr 88:826S-9S (2008)
DOI:10.1093/ajcn/88.3.826S
Reference
  Authors
Wang X, Zhou B
  Title
Dietary zinc absorption: A play of Zips and ZnTs in the gut.
  Journal
IUBMB Life 62:176-82 (2010)
DOI:10.1002/iub.291
Reference
  Authors
Lichten LA, Cousins RJ
  Title
Mammalian zinc transporters: nutritional and physiologic regulation.
  Journal
Annu Rev Nutr 29:153-76 (2009)
DOI:10.1146/annurev-nutr-033009-083312
Reference
  Authors
Quamme GA
  Title
Recent developments in intestinal magnesium absorption.
  Journal
Curr Opin Gastroenterol 24:230-5 (2008)
DOI:10.1097/MOG.0b013e3282f37b59
Reference
  Authors
Donowitz M, Mohan S, Zhu CX, Chen TE, Lin R, Cha B, Zachos NC, Murtazina R, Sarker R, Li X
  Title
NHE3 regulatory complexes.
  Journal
J Exp Biol 212:1638-46 (2009)
DOI:10.1242/jeb.028605
Reference
  Authors
Kato A, Romero MF
  Title
Regulation of Electroneutral NaCl Absorption by the Small Intestine.
  Journal
Annu Rev Physiol 73:261-81 (2011)
DOI:10.1146/annurev-physiol-012110-142244
Reference
  Authors
Sabbagh Y, O'Brien SP, Song W, Boulanger JH, Stockmann A, Arbeeny C, Schiavi SC
  Title
Intestinal npt2b plays a major role in phosphate absorption and homeostasis.
  Journal
J Am Soc Nephrol 20:2348-58 (2009)
DOI:10.1681/ASN.2009050559
Reference
  Authors
Marks J, Srai SK, Biber J, Murer H, Unwin RJ, Debnam ES
  Title
Intestinal phosphate absorption and the effect of vitamin D: a comparison of rats with mice.
  Journal
Exp Physiol 91:531-7 (2006)
DOI:10.1113/expphysiol.2005.032516
Related
pathway
map00860  Porphyrin metabolism
map04530  Tight junction
map04973  Carbohydrate digestion and absorption
map04974  Protein digestion and absorption
KO pathway
ko04978   

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