KEGG   PATHWAY: mdm04016
Entry
mdm04016                    Pathway                                
Name
MAPK signaling pathway - plant - Malus domestica (apple)
Description
Mitogen-activated protein kinase (MAPK) cascades, the evolutionarily conserved signaling modules in all eukaryotes, serve in transducing extracellular signals to the nucleus or cytoplasm for appropriate cellular responses, including cell division, differentiation, programmed cell death, and adaption to various stresses. In plant, several cascades are triggered by different biotic and abiotic stress stimuli such as pathogen infection, wounding, low temperature, drought, osmotic shock, high salinity, and reactive oxygen species. MAPK pathways also play pivotal roles in processes such as hormonal and developmental signaling. Multiple functional pathways initiated from distinct receptors often share the same kinase components while maintaining their signaling specificity. In contrast to those of animals and fungi, all the plant MAPK genes that have been reported belong to extracellular signal-regulated kinase (ERK) subfamily.
Class
Environmental Information Processing; Signal transduction
Pathway map
mdm04016  MAPK signaling pathway - plant
mdm04016

Other DBs
GO: 0000165
Organism
Malus domestica (apple) [GN:mdm]
Gene
103434977  LRR receptor-like serine/threonine-protein kinase FLS2 [KO:K13420] [EC:2.7.11.1]
103402256  BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1-like [KO:K13416] [EC:2.7.10.1 2.7.11.1]
103402254  BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1-like [KO:K13416] [EC:2.7.10.1 2.7.11.1]
103416333  BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1-like isoform X1 [KO:K13416] [EC:2.7.10.1 2.7.11.1]
103416332  BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1-like isoform X1 [KO:K13416] [EC:2.7.10.1 2.7.11.1]
103453670  LOW QUALITY PROTEIN: BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 [KO:K13416] [EC:2.7.10.1 2.7.11.1]
103439421  mitogen-activated protein kinase kinase kinase 1-like [KO:K13414] [EC:2.7.11.25]
103401930  mitogen-activated protein kinase kinase kinase 1-like isoform X1 [KO:K13414] [EC:2.7.11.25]
103400837  mitogen-activated protein kinase kinase 2-like [KO:K20603] [EC:2.7.12.2]
103450713  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase 2-like [KO:K20603] [EC:2.7.12.2]
103439212  LOW QUALITY PROTEIN: mitogen-activated protein kinase homolog MMK2-like [KO:K20600] [EC:2.7.11.24]
103436591  protein MKS1 [KO:K20725]
103424771  protein MKS1-like [KO:K20725]
103412246  protein MKS1-like [KO:K20725]
103414937  protein MKS1-like [KO:K20725]
103447297  probable WRKY transcription factor 26 [KO:K13424]
103433719  WRKY9; probable WRKY transcription factor 33 [KO:K13424]
103407650  probable WRKY transcription factor 26 [KO:K13424]
103413903  probable WRKY transcription factor 33 [KO:K13424]
103405206  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase 5 [KO:K13413] [EC:2.7.12.2]
103443229  mitogen-activated protein kinase kinase 5-like [KO:K13413] [EC:2.7.12.2]
114822596  mitogen-activated protein kinase kinase 5-like [KO:K13413] [EC:2.7.12.2]
103447833  mitogen-activated protein kinase 3 [KO:K20536] [EC:2.7.11.24]
103421892  mitogen-activated protein kinase 3-like [KO:K20536] [EC:2.7.11.24]
103446754  mitogen-activated protein kinase homolog NTF4 [KO:K14512] [EC:2.7.11.24]
103456346  mitogen-activated protein kinase homolog D5 [KO:K14512] [EC:2.7.11.24]
103444633  transcription factor VIP1 [KO:K20557]
103402159  transcription factor VIP1-like [KO:K20557]
103445181  pathogenesis-related protein 1A-like [KO:K13449]
103449039  basic form of pathogenesis-related protein 1-like [KO:K13449]
103436283  basic form of pathogenesis-related protein 1-like [KO:K13449]
103436285  pathogenesis-related protein 1-like [KO:K13449]
103436280  pathogenesis-related leaf protein 4-like [KO:K13449]
103434045  pathogenesis-related protein 1-like [KO:K13449]
103436302  pathogenesis-related protein 1-like precursor [KO:K13449]
114827291  pathogenesis-related leaf protein 6-like [KO:K13449]
114827612  basic form of pathogenesis-related protein 1-like [KO:K13449]
103436284  pathogenesis-related protein 1A-like [KO:K13449]
103410146  WRKY transcription factor 22-like [KO:K13425]
103407953  WRKY transcription factor 22 [KO:K13425]
103426983  probable WRKY transcription factor 29 [KO:K13426]
103439197  probable WRKY transcription factor 29 isoform X1 [KO:K13426]
103411726  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
103428489  1-aminocyclopropane-1-carboxylate synthase 1-like [KO:K20772] [EC:4.4.1.14]
103408235  1-aminocyclopropane-1-carboxylate synthase 1 [KO:K20772] [EC:4.4.1.14]
103439201  1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
103412151  serine/threonine-protein kinase OXI1-like [KO:K20714] [EC:2.7.11.1]
103435899  serine/threonine-protein kinase OXI1 [KO:K20714] [EC:2.7.11.1]
103455035  nucleoside diphosphate kinase 2, chloroplastic [KO:K00940] [EC:2.7.4.6]
103437370  nucleoside diphosphate kinase III, chloroplastic/mitochondrial-like [KO:K00940] [EC:2.7.4.6]
103404467  nucleoside diphosphate kinase III, chloroplastic/mitochondrial-like [KO:K00940] [EC:2.7.4.6]
103439015  nucleoside diphosphate kinase 1 [KO:K00940] [EC:2.7.4.6]
114825364  nucleoside diphosphate kinase 2, chloroplastic-like [KO:K00940] [EC:2.7.4.6]
103450944  mitogen-activated protein kinase kinase kinase NPK1 isoform X1 [KO:K20606] [EC:2.7.11.25]
103453090  mitogen-activated protein kinase kinase kinase NPK1-like [KO:K20606] [EC:2.7.11.25]
103408550  mitogen-activated protein kinase kinase kinase NPK1-like isoform X1 [KO:K20606] [EC:2.7.11.25]
103442219  mitogen-activated protein kinase kinase 3 [KO:K20607] [EC:2.7.12.2]
103450443  mitogen-activated protein kinase homolog NTF3-like [KO:K20535] [EC:2.7.11.24]
103440304  mitogen-activated protein kinase homolog NTF3 [KO:K20535] [EC:2.7.11.24]
103418305  mitogen-activated protein kinase 7 [KO:K20537] [EC:2.7.11.24]
114820333  mitogen-activated protein kinase 7 [KO:K20537] [EC:2.7.11.24]
103451053  ETR5; LOW QUALITY PROTEIN: protein EIN4 [KO:K14509] [EC:2.7.13.-]
103434196  LOW QUALITY PROTEIN: protein EIN4-like [KO:K14509] [EC:2.7.13.-]
103401284  ethylene receptor [KO:K14509] [EC:2.7.13.-]
103408133  probable ethylene response sensor 1 [KO:K14509] [EC:2.7.13.-]
103449156  ethylene response sensor 1-like [KO:K14509] [EC:2.7.13.-]
103456365  ethylene receptor-like [KO:K14509] [EC:2.7.13.-]
103436150  ethylene receptor 2 precursor [KO:K14509] [EC:2.7.13.-]
103424105  ethylene receptor 2-like [KO:K14509] [EC:2.7.13.-]
103449391  CTR1; serine/threonine-protein kinase CTR1 [KO:K14510] [EC:2.7.11.1]
103413483  serine/threonine-protein kinase CTR1-like isoform X1 [KO:K14510] [EC:2.7.11.1]
103401096  protein RTE1-HOMOLOG isoform X1 [KO:K20726]
103455831  protein REVERSION-TO-ETHYLENE SENSITIVITY1 [KO:K20726]
114826469  protein REVERSION-TO-ETHYLENE SENSITIVITY1-like [KO:K20726]
103400883  protein RTE1-HOMOLOG-like isoform X1 [KO:K20726]
103446622  probable copper-transporting ATPase HMA5 [KO:K17686] [EC:7.2.2.8]
103446006  copper-transporting ATPase RAN1-like isoform X1 [KO:K17686] [EC:7.2.2.8]
103454742  probable copper-transporting ATPase HMA5 isoform X1 [KO:K17686] [EC:7.2.2.8]
103424630  LOW QUALITY PROTEIN: copper-transporting ATPase PAA2, chloroplastic-like [KO:K17686] [EC:7.2.2.8]
103435303  copper-transporting ATPase RAN1-like [KO:K17686] [EC:7.2.2.8]
103436541  copper-transporting ATPase PAA1, chloroplastic [KO:K17686] [EC:7.2.2.8]
114825632  LOW QUALITY PROTEIN: probable copper-transporting ATPase HMA5 [KO:K17686] [EC:7.2.2.8]
103436047  LOW QUALITY PROTEIN: copper-transporting ATPase HMA4-like [KO:K17686] [EC:7.2.2.8]
103438110  mitogen-activated protein kinase kinase 9-like [KO:K20604] [EC:2.7.12.2]
103431251  mitogen-activated protein kinase kinase 9-like [KO:K20604] [EC:2.7.12.2]
103403668  mitogen-activated protein kinase kinase 9-like [KO:K20604] [EC:2.7.12.2]
103447068  ETHYLENE INSENSITIVE 3-like 3 protein [KO:K14514]
103438744  ETHYLENE INSENSITIVE 3-like 1 protein isoform X1 [KO:K14514]
103409091  ETHYLENE INSENSITIVE 3-like 1 protein [KO:K14514]
103431796  ETHYLENE INSENSITIVE 3-like 1 protein [KO:K14514]
103421404  ETHYLENE INSENSITIVE 3-like 1 protein [KO:K14514]
103428420  ETHYLENE INSENSITIVE 3-like 1 protein [KO:K14514]
103418493  protein ETHYLENE INSENSITIVE 3-like [KO:K14514]
103425190  putative ETHYLENE INSENSITIVE 3-like 4 protein [KO:K14514]
103429812  LOW QUALITY PROTEIN: ETHYLENE INSENSITIVE 3-like 3 protein [KO:K14514]
114821377  putative ETHYLENE INSENSITIVE 3-like 4 protein [KO:K14514]
103450050  ethylene-insensitive protein 2-like [KO:K14513]
103433224  EIN2; ethylene-insensitive protein 2 [KO:K14513]
103456202  EIN3-binding F-box protein 1-like [KO:K14515]
103400415  EIN3-binding F-box protein 1-like [KO:K14515]
103428845  EIN3-binding F-box protein 1-like [KO:K14515]
103426588  EIN3-binding F-box protein 1-like [KO:K14515]
103434145  5'-3' exoribonuclease 4-like [KO:K20553] [EC:3.1.13.-]
103451007  5'-3' exoribonuclease 4-like [KO:K20553] [EC:3.1.13.-]
103451058  ethylene-responsive transcription factor 1B-like [KO:K14516]
103404043  ethylene-responsive transcription factor 1B-like [KO:K14516]
103453426  ethylene-responsive transcription factor 1B-like [KO:K14516]
103412248  ethylene-responsive transcription factor 1B-like [KO:K14516]
103427742  ethylene-responsive transcription factor 1B-like [KO:K14516]
114824904  ethylene-responsive transcription factor 1B-like [KO:K14516]
103455731  endochitinase [KO:K20547] [EC:3.2.1.14]
103401024  endochitinase-like precursor [KO:K20547] [EC:3.2.1.14]
103400490  endochitinase-like [KO:K20547] [EC:3.2.1.14]
103436897  transcription factor MYC2 [KO:K13422]
103404780  transcription factor MYC2-like [KO:K13422]
103454812  transcription factor MYC2-like [KO:K13422]
103413926  abscisic acid receptor PYL3 [KO:K14496]
103443519  abscisic acid receptor PYL8-like [KO:K14496]
103432868  abscisic acid receptor PYL4 [KO:K14496]
103404778  abscisic acid receptor PYR1-like [KO:K14496]
103433682  abscisic acid receptor PYL4-like [KO:K14496]
103436894  abscisic acid receptor PYR1-like [KO:K14496]
103434883  abscisic acid receptor PYL12-like [KO:K14496]
103439853  abscisic acid receptor PYL8 [KO:K14496]
103439337  abscisic acid receptor PYL3-like [KO:K14496]
103440595  abscisic acid receptor PYL2 [KO:K14496]
103406427  abscisic acid receptor PYL4-like [KO:K14496]
103415398  abscisic acid receptor PYL2-like [KO:K14496]
114819947  abscisic acid receptor PYL4-like isoform X1 [KO:K14496]
103441151  probable protein phosphatase 2C 75 [KO:K14497] [EC:3.1.3.16]
103443860  protein phosphatase 2C 51-like isoform X1 [KO:K14497] [EC:3.1.3.16]
103447497  probable protein phosphatase 2C 24 [KO:K14497] [EC:3.1.3.16]
103453589  LOW QUALITY PROTEIN: protein phosphatase 2C 50-like [KO:K14497] [EC:3.1.3.16]
103400838  protein phosphatase 2C 77 [KO:K14497] [EC:3.1.3.16]
103400712  protein phosphatase 2C 56-like [KO:K14497] [EC:3.1.3.16]
103440783  protein phosphatase 2C 77-like [KO:K14497] [EC:3.1.3.16]
103407751  probable protein phosphatase 2C 24 [KO:K14497] [EC:3.1.3.16]
103415390  protein phosphatase 2C 53-like isoform X1 [KO:K14497] [EC:3.1.3.16]
103428272  probable protein phosphatase 2C 8 [KO:K14497] [EC:3.1.3.16]
103401766  protein phosphatase 2C 16-like [KO:K14497] [EC:3.1.3.16]
103435436  protein phosphatase 2C 37 [KO:K14497] [EC:3.1.3.16]
114826111  protein phosphatase 2C 37-like [KO:K14497] [EC:3.1.3.16]
114826185  protein phosphatase 2C 51-like [KO:K14497] [EC:3.1.3.16]
103432846  serine/threonine-protein kinase SAPK3-like [KO:K14498] [EC:2.7.11.1]
103448631  serine/threonine-protein kinase SAPK2 [KO:K14498] [EC:2.7.11.1]
103429472  serine/threonine-protein kinase SAPK2-like [KO:K14498] [EC:2.7.11.1]
103411041  serine/threonine-protein kinase SRK2A-like [KO:K14498] [EC:2.7.11.1]
103425402  serine/threonine-protein kinase SRK2A [KO:K14498] [EC:2.7.11.1]
103402284  serine/threonine-protein kinase SRK2E [KO:K14498] [EC:2.7.11.1]
103436962  serine/threonine-protein kinase SAPK3-like [KO:K14498] [EC:2.7.11.1]
103402785  serine/threonine-protein kinase SRK2I [KO:K14498] [EC:2.7.11.1]
103416001  serine/threonine-protein kinase SRK2I-like [KO:K14498] [EC:2.7.11.1]
103422052  serine/threonine-protein kinase SAPK2-like [KO:K14498] [EC:2.7.11.1]
103420076  serine/threonine-protein kinase SAPK1-like isoform X2 [KO:K14498] [EC:2.7.11.1]
103420077  serine/threonine-protein kinase SAPK2-like [KO:K14498] [EC:2.7.11.1]
114819105  serine/threonine-protein kinase SRK2E-like [KO:K14498] [EC:2.7.11.1]
103404835  mitogen-activated protein kinase kinase kinase 18 [KO:K20716]
103434588  mitogen-activated protein kinase kinase kinase 18-like [KO:K20716]
103412546  mitogen-activated protein kinase kinase kinase 18-like [KO:K20716]
103429258  mitogen-activated protein kinase kinase kinase 18-like [KO:K20716]
103430108  mitogen-activated protein kinase kinase kinase 18-like [KO:K20716]
103442616  mitogen-activated protein kinase kinase kinase 18-like [KO:K20716]
103445262  catalase isozyme 1-like [KO:K03781] [EC:1.11.1.6]
103436733  catalase isozyme 1 [KO:K03781] [EC:1.11.1.6]
103412104  LOW QUALITY PROTEIN: catalase isozyme 1 [KO:K03781] [EC:1.11.1.6]
103452671  calcium-binding protein CP1 [KO:K02183]
103455657  calmodulin [KO:K02183]
103451809  probable calcium-binding protein CML45 [KO:K02183]
103454710  calmodulin [KO:K02183]
103438271  calmodulin-like [KO:K02183]
103404453  probable calcium-binding protein CML45 [KO:K02183]
103426118  calmodulin-7 [KO:K02183]
103432260  calmodulin-6-like [KO:K02183]
103409519  calmodulin-6-like [KO:K02183]
103409831  probable calcium-binding protein CML45 [KO:K02183]
103410125  calmodulin-7 [KO:K02183]
114825502  probable calcium-binding protein CML47 [KO:K02183]
114820220  calmodulin-7 [KO:K02183]
114822078  calcium-binding protein CP1-like [KO:K02183]
103423083  calmodulin-like protein 11 [KO:K02183]
103432280  calmodulin-like protein 11 [KO:K02183]
103401885  probable calcium-binding protein CML29 [KO:K02183]
103442362  probable calcium-binding protein CML45 [KO:K02183]
103430595  LOW QUALITY PROTEIN: respiratory burst oxidase homolog protein A-like [KO:K13447] [EC:1.6.3.- 1.11.1.-]
103455417  respiratory burst oxidase homolog protein A-like isoform X1 [KO:K13447] [EC:1.6.3.- 1.11.1.-]
103412309  respiratory burst oxidase homolog protein A-like isoform X1 [KO:K13447] [EC:1.6.3.- 1.11.1.-]
103438671  respiratory burst oxidase homolog protein C [KO:K13447] [EC:1.6.3.- 1.11.1.-]
103441525  respiratory burst oxidase homolog protein D-like [KO:K13447] [EC:1.6.3.- 1.11.1.-]
103400905  respiratory burst oxidase homolog protein E isoform X2 [KO:K13447] [EC:1.6.3.- 1.11.1.-]
103433139  respiratory burst oxidase homolog protein D-like [KO:K13447] [EC:1.6.3.- 1.11.1.-]
114819751  respiratory burst oxidase homolog protein E-like [KO:K13447] [EC:1.6.3.- 1.11.1.-]
103404726  protein EPIDERMAL PATTERNING FACTOR 1 [KO:K20729]
103455768  LRR receptor-like serine/threonine-protein kinase ERECTA isoform X2 [KO:K20718] [EC:2.7.11.1]
103439673  LRR receptor-like serine/threonine-protein kinase ERL1 [KO:K20718] [EC:2.7.11.1]
103455645  LOW QUALITY PROTEIN: LRR receptor-like serine/threonine-protein kinase ERECTA [KO:K20718] [EC:2.7.11.1]
103442920  mitogen-activated protein kinase kinase kinase YODA-like [KO:K20717] [EC:2.7.11.25]
103439781  mitogen-activated protein kinase kinase kinase YODA-like [KO:K20717] [EC:2.7.11.25]
114825650  mitogen-activated protein kinase kinase kinase YODA-like isoform X1 [KO:K20717] [EC:2.7.11.25]
103417877  transcription factor SPEECHLESS-like [KO:K20558]
103439848  transcription factor SPEECHLESS [KO:K20558]
Reference
PMID:11875555
  Authors
Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J
  Title
MAP kinase signalling cascade in Arabidopsis innate immunity.
  Journal
Nature 415:977-83 (2002)
DOI:10.1038/415977a
Reference
PMID:12119167
  Authors
  Title
Mitogen-activated protein kinase cascades in plants: a new nomenclature.
  Journal
Trends Plant Sci 7:301-8 (2002)
DOI:10.1016/S1360-1385(02)02302-6
Reference
PMID:18570633
  Authors
Colcombet J, Hirt H
  Title
Arabidopsis MAPKs: a complex signalling network involved in multiple biological processes.
  Journal
Biochem J 413:217-26 (2008)
DOI:10.1042/BJ20080625
Reference
PMID:18692429
  Authors
Kendrick MD, Chang C
  Title
Ethylene signaling: new levels of complexity and regulation.
  Journal
Curr Opin Plant Biol 11:479-85 (2008)
DOI:10.1016/j.pbi.2008.06.011
Reference
PMID:20441529
  Authors
Rodriguez MC, Petersen M, Mundy J
  Title
Mitogen-activated protein kinase signaling in plants.
  Journal
Annu Rev Plant Biol 61:621-49 (2010)
DOI:10.1146/annurev-arplant-042809-112252
Reference
PMID:20980831
  Authors
Taj G, Agarwal P, Grant M, Kumar A
  Title
MAPK machinery in plants: recognition and response to different stresses through multiple signal transduction pathways.
  Journal
Plant Signal Behav 5:1370-8 (2010)
DOI:10.4161/psb.5.11.13020
Reference
PMID:23263767
  Authors
Meng X, Wang H, He Y, Liu Y, Walker JC, Torii KU, Zhang S
  Title
A MAPK cascade downstream of ERECTA receptor-like protein kinase regulates Arabidopsis inflorescence architecture by promoting localized cell proliferation.
  Journal
Plant Cell 24:4948-60 (2012)
DOI:10.1105/tpc.112.104695
Reference
PMID:25720833
  Authors
Danquah A, de Zelicourt A, Boudsocq M, Neubauer J, Frei Dit Frey N, Leonhardt N, Pateyron S, Gwinner F, Tamby JP, Ortiz-Masia D, Marcote MJ, Hirt H, Colcombet J
  Title
Identification and characterization of an ABA-activated MAP kinase cascade in Arabidopsis thaliana.
  Journal
Plant J 82:232-44 (2015)
DOI:10.1111/tpj.12808
KO pathway
ko04016   

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Genome (1)   
   KEGG GENOME (1)   
Gene (200)   
   KEGG GENES (200)   
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