KEGG   PATHWAY: mle00290
Entry
mle00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Mycobacterium leprae TN
Class
Metabolism; Amino acid metabolism
Pathway map
mle00290  Valine, leucine and isoleucine biosynthesis
mle00290

Module
mle_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:mle00290]
mle_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:mle00290]
mle_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:mle00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Mycobacterium leprae TN [GN:mle]
Gene
ML1209  ilvA; threonine deaminase [KO:K01754] [EC:4.3.1.19]
ML1685  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
ML1684  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
ML1691  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
ML0354  ilvX; putative acetohydroxyacid synthase I large subunit [KO:K01652] [EC:2.2.1.6]
ML1696  ilvB; acetolactate synthase I large subunit [KO:K01652] [EC:2.2.1.6]
ML1695  ilvN; acetolactate synthase I small subunit [KO:K01653] [EC:2.2.1.6]
ML1694  ilvC; ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
ML2608  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
ML0866  ilvE; putative branched-chain-amino-acid transaminase [KO:K00826] [EC:2.6.1.42]
ML2502  probable aspartate aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
ML2324  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
mle00260  Glycine, serine and threonine metabolism
mle00280  Valine, leucine and isoleucine degradation
mle00620  Pyruvate metabolism
KO pathway
ko00290   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG GENES (12)   
All databases (13)   

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