KEGG   PATHWAY: mtu05152
Entry
mtu05152                    Pathway                                
Name
Tuberculosis - Mycobacterium tuberculosis H37Rv
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
mtu05152  Tuberculosis
mtu05152

Organism
Mycobacterium tuberculosis H37Rv [GN:mtu]
Gene
Rv3818  hypothetical protein [KO:K14952]
Rv3763  lpqH; lipoprotein LpqH [KO:K14953]
Rv1411c  lprG; lipoprotein LprG [KO:K14954]
Rv1270c  lprA; lipoprotein LprA [KO:K14955]
Rv0928  pstS3; phosphate ABC transporter substrate-binding lipoprotein PstS [KO:K02040]
Rv0932c  pstS2; phosphate ABC transporter substrate-binding lipoprotein PstS [KO:K02040]
Rv0934  pstS1; phosphate ABC transporter substrate-binding lipoprotein PstS [KO:K02040]
Rv0350  dnaK; chaperone protein DnaK [KO:K04043]
Rv0440  groEL2; molecular chaperone GroEL [KO:K04077] [EC:5.6.1.7]
Rv3417c  groEL1; chaperonin GroEL [KO:K04077] [EC:5.6.1.7]
Rv3875  esxA; ESAT-6 protein EsxA [KO:K14956]
Rv0288  esxH; ESAT-6-like protein EsxH [KO:K14956]
Rv1793  esxN; ESAT-6 like protein EsxN [KO:K14956]
Rv3444c  esxT; ESAT-6 like protein EsxT [KO:K14956]
Rv3445c  esxU; ESAT-6 like protein EsxU [KO:K14956]
Rv3620c  esxW; ESAT-6 like protein EsxW [KO:K14956]
Rv3874  esxB; ESAT-6-like protein EsxB [KO:K14956]
Rv3890c  esxC; ESAT-6 like protein EsxC [KO:K14956]
Rv3891c  esxD; ESAT-6 like protein EsxD [KO:K14956]
Rv3905c  esxF; ESAT-6 like protein EsxF [KO:K14956]
Rv2346c  esxO; ESAT-6 like protein EsxO [KO:K14956]
Rv2347c  esxP; ESAT-6 like protein EsxP [KO:K14956]
Rv3017c  esxQ; ESAT-6 like protein EsxQ [KO:K14956]
Rv3019c  esxR; ESAT-6 like protein EsxR [KO:K14956]
Rv3020c  esxS; ESAT-6 like protein EsxS [KO:K14956]
Rv3619c  esxV; ESAT-6 like protein EsxV [KO:K14956]
Rv0287  esxG; ESAT-6 like protein EsxG [KO:K14956]
Rv1037c  esxI; ESAT-6 like protein EsxI [KO:K14956]
Rv1038c  esxJ; ESAT-6 like protein EsxJ [KO:K14956]
Rv1197  esxK; ESAT-6 like protein EsxK [KO:K14956]
Rv1198  esxL; ESAT-6 like protein EsxL [KO:K14956]
Rv3904c  esxE; ESAT-6 like protein EsxE [KO:K14956]
Rv3310  sapM; acid phosphatase [KO:K21302] [EC:3.1.3.64]
Rv0410c  pknG; serine/threonine-protein kinase PknG [KO:K14949] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C01561  Calcidiol
C01673  Calcitriol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  Sphingosine 1-phosphate
C19190  Trehalose-6,6'-dibehenate
C21790  Trehalose dimycolate
G13101  Lipomannan
G13105  Triacylated phosphatidyl-myo-inositol pentamannoside
G13106  Triacylated phosphatidyl-myo-inositol hexamannoside
G13108  Triacylated phosphatidyl-myo-inositol dimannoside
G13109  Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112  Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113  Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13114  Lipoarabinomannan
G13115  Mannose-capped lipoarabinomannan
Reference
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594
Reference
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x
Reference
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002
Reference
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467
Reference
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x
Reference
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571
Reference
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840
Reference
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003
Reference
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x
Reference
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x
Reference
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128
Reference
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006
Reference
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463
Reference
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003
Reference
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5
Related
pathway
mtu00571  Lipoarabinomannan (LAM) biosynthesis
KO pathway
ko05152   

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