KEGG   PATHWAY: mul00290
Entry
mul00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Mycobacterium ulcerans
Class
Metabolism; Amino acid metabolism
Pathway map
mul00290  Valine, leucine and isoleucine biosynthesis
mul00290

Module
mul_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:mul00290]
mul_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:mul00290]
mul_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:mul00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Mycobacterium ulcerans [GN:mul]
Gene
MUL_1550  ilvA; threonine dehydratase IlvA [KO:K01754] [EC:4.3.1.19]
MUL_1968  leuC; 3-isopropylmalate dehydratase (large subunit) LeuC [KO:K01703] [EC:4.2.1.33 4.2.1.35]
MUL_1969  leuD; 3-isopropylmalate dehydratase (small subunit) LeuD [KO:K01704] [EC:4.2.1.33 4.2.1.35]
MUL_1953  leuB; 3-isopropylmalate dehydrogenase LeuB [KO:K00052] [EC:1.1.1.85]
MUL_4072  ilvX; acetohydroxyacid synthase IlvX [KO:K01652] [EC:2.2.1.6]
MUL_2433  ilvB1_1; acetolactate synthase (large subunit) IlvB1_1 [KO:K01652] [EC:2.2.1.6]
MUL_1947  ilvB1; acetolactate synthase (large subunit) IlvB1 [KO:K01652] [EC:2.2.1.6]
MUL_1348  ilvB1_2; acetolactate synthase (large subunit) IlvB1_2 [KO:K01652] [EC:2.2.1.6]
MUL_1948  ilvN; acetolactate synthase (small subunit) IlvN [KO:K01653] [EC:2.2.1.6]
MUL_1949  ilvC; ketol-acid reductoisomerase IlvC [KO:K00053] [EC:1.1.1.86]
MUL_1082  ilvD; dihydroxy-acid dehydratase IlvD [KO:K01687] [EC:4.2.1.9]
MUL_3570  ilvE; branched-chain amino acid transaminase IlvE [KO:K00826] [EC:2.6.1.42]
MUL_0573  aspC; aspartate aminotransferase AspC [KO:K14260] [EC:2.6.1.66 2.6.1.2]
MUL_4300  leuA; 2-isopropylmalate synthase LeuA [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
mul00260  Glycine, serine and threonine metabolism
mul00280  Valine, leucine and isoleucine degradation
mul00620  Pyruvate metabolism
KO pathway
ko00290   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG GENES (14)   
All databases (15)   

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