KEGG   PATHWAY: nca03440
Entry
nca03440                    Pathway                                
Name
Homologous recombination - Nocardioides sp. JS614
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
nca03440  Homologous recombination
nca03440

Other DBs
GO: 0000724
Organism
Nocardioides sp. JS614 [GN:nca]
Gene
Noca_4663  single-strand binding protein [KO:K03111]
Noca_1368  single-strand binding protein [KO:K03111]
Noca_2262  single-strand binding protein/Primosomal replication protein n [KO:K03111]
Noca_2477  single-strand binding protein/Primosomal replication protein n [KO:K03111]
Noca_0004  DNA replication and repair protein RecF [KO:K03629]
Noca_1930  DNA replication and repair protein RecO [KO:K03584]
Noca_0319  DNA replication and repair protein RecR [KO:K06187]
Noca_2341  RecA protein [KO:K03553]
Noca_3006  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Noca_2386  Holliday junction DNA helicase subunit RuvA [KO:K03550]
Noca_2387  Holliday junction DNA helicase subunit RuvB [KO:K03551] [EC:5.6.2.4]
Noca_2385  Holliday junction endonuclease RuvC [KO:K01159] [EC:3.1.21.10]
Noca_3285  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
Noca_0252  exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:3.1.11.5]
Noca_0251  DNA helicase/exodeoxyribonuclease V, gamma subunit [KO:K03583] [EC:3.1.11.5]
Noca_0253  DNA helicase/exodeoxyribonuclease V, alpha subunit [KO:K03581] [EC:3.1.11.5]
Noca_1102  ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member-like protein [KO:K03581] [EC:3.1.11.5]
Noca_1721  ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member-like protein [KO:K03581] [EC:3.1.11.5]
Noca_3050  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Noca_0002  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Noca_0317  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Noca_1888  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Noca_0387  DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
Noca_3128  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Noca_3810  Exonuclease, RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Noca_2440  primosomal protein N' (replication factor Y) (superfamily II helicase) [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG GENES (26)   
All databases (27)   

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