KEGG   PATHWAY: pai03410
Entry
pai03410                    Pathway                                

Name
Base excision repair - Pyrobaculum aerophilum
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
Pathway map
pai03410  Base excision repair
pai03410

Other DBs
GO: 0006284 0006285 0006286 0006287 0006288
Organism
Pyrobaculum aerophilum [GN:pai]
Gene
PAE0880  DNA-(apurinic or apyrimidinic site) lyase (endonuclease III, PaNth) [KO:K10773] [EC:4.2.99.18]
PAE0651  uracil DNA glycosylase (Pa-UDGa) [KO:K21929] [EC:3.2.2.27]
PAE1327  uracil-DNA glycosylase (Pa-UDGb) [KO:K21929] [EC:3.2.2.27]
PAE3199  U/G & T/G mismatch specific glycosylase (Pa-MIG) [KO:K03575] [EC:3.2.2.31]
PAE3257  DNA-(apurinic or apyrimidinic site) lyase (endonuclease IV) [KO:K01151] [EC:3.1.21.2]
PAE2792  conserved hypothetical protein part 1, authentic frameshift [KO:K07462] [EC:3.1.-.-]
PAE3038  proliferating-cell nuclear antigen homolog (PCNA) [KO:K04802]
PAE0720  proliferating-cell nuclear antigen homolog (PCNA) [KO:K04802]
PAE0833  DNA ligase [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
PAE0698  DNA endonuclease rad2 homolog [KO:K04799] [EC:3.-.-.-]
Reference
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
DOI:10.1016/j.dnarep.2007.01.009
Reference
  Authors
Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
  Title
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
  Journal
J Bacteriol 193:4495-508 (2011)
DOI:10.1128/JB.00233-11
Reference
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
ko03410   

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