KEGG   PATHWAY: pbe04141
Entry
pbe04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Plasmodium berghei
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
pbe04141  Protein processing in endoplasmic reticulum
pbe04141

Other DBs
GO: 0030433 0034976
Organism
Plasmodium berghei [GN:pbe]
Gene
PBANKA_1359000  protein transport protein SEC61 subunit alpha, putative [KO:K10956]
PBANKA_0709000  protein transport protein SEC61 subunit beta, putative [KO:K09481]
PBANKA_0306900  Sec61-gamma subunit of protein translocation complex, putative [KO:K07342]
PBANKA_1302200  translocation protein SEC62, putative [KO:K12275]
PBANKA_1417300  translocation protein SEC63, putative [KO:K09540]
PBANKA_0210900  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2, putative [KO:K12668]
PBANKA_0820500  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1, putative [KO:K12670]
PBANKA_0931400  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3, putative [KO:K07151] [EC:2.4.99.18]
PBANKA_1357200  heat shock protein 110, putative [KO:K09486]
PBANKA_0818900  endoplasmic reticulum chaperone BiP, putative [KO:K09490] [EC:3.6.4.10]
PBANKA_1437300  endoplasmin, putative [KO:K09487]
PBANKA_0718800  small GTP-binding protein sar1, putative [KO:K07953] [EC:3.6.5.-]
PBANKA_1445400  protein transport protein SEC13 [KO:K14004]
PBANKA_0311000  protein transport protein SEC31, putative [KO:K14005]
PBANKA_0708000  protein transport protein SEC23, putative [KO:K14006]
PBANKA_1137200  protein transport protein Sec24A, putative [KO:K14007]
PBANKA_0702800  protein disulfide isomerase [KO:K09580] [EC:5.3.4.1]
PBANKA_0914300  protein disulfide isomerase related protein, putative [KO:K09584] [EC:5.3.4.1]
PBANKA_0924300  endoplasmic reticulum oxidoreductin, putative [KO:K10950] [EC:1.8.4.-]
PBANKA_0516300  DER1-like protein, putative [KO:K13989]
PBANKA_1331800  derlin-1, putative [KO:K13989]
PBANKA_1222400  ubiquitin regulatory protein, putative [KO:K14012]
PBANKA_1118600  cell division cycle protein 48 homologue, putative [KO:K13525]
PBANKA_1107300  nuclear protein localization protein 4, putative [KO:K14015]
PBANKA_0817500  ubiquitin fusion degradation protein 1, putative [KO:K14016]
PBANKA_1024700  ubiquitin fusion degradation protein 1, putative [KO:K14016]
PBANKA_1239600  ubiquitin fusion degradation protein 1, putative [KO:K14016]
PBANKA_0711900  heat shock protein 70 [KO:K03283]
PBANKA_0610900  HSP40, subfamily A, putative [KO:K09503]
PBANKA_0911800  DnaJ protein, putative [KO:K09518]
PBANKA_0805700  heat shock protein 90, putative [KO:K04079]
PBANKA_1008000  conserved protein, unknown function [KO:K09562]
PBANKA_0714300  small heat shock protein HSP20 [KO:K13993]
PBANKA_1403000  small heat shock protein, putative [KO:K13993]
PBANKA_1210100  DNA repair protein RAD23, putative [KO:K10839]
PBANKA_0934200  ubiquitin domain-containing protein DSK2, putative [KO:K04523]
PBANKA_0916400  ubiquitin-like protein, putative [KO:K04523]
PBANKA_1441600  ataxin-3, putative [KO:K11863] [EC:3.4.22.-]
PBANKA_0212100  eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
PBANKA_0821900  ubiquitin-conjugating enzyme E2, putative [KO:K10575] [EC:2.3.2.23]
PBANKA_1020900  ERAD-associated E3 ubiquitin-protein ligase HRD1, putative [KO:K10601] [EC:2.3.2.27]
PBANKA_0804900  E3 ubiquitin-protein ligase, putative [KO:K09561] [EC:2.3.2.27]
PBANKA_0602800  ubiquitin-conjugating enzyme E2, putative [KO:K06689] [EC:2.3.2.23]
PBANKA_0806200  E3 ubiquitin-protein ligase RBX1, putative [KO:K03868] [EC:2.3.2.32]
PBANKA_1426500  cullin-1, putative [KO:K03347]
PBANKA_1142900  suppressor of kinetochore protein 1, putative [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
pbe00510  N-Glycan biosynthesis
pbe03050  Proteasome
pbe03060  Protein export
KO pathway
ko04141   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (46)   
   KEGG GENES (46)   
All databases (47)   

Download RDF
DBGET integrated database retrieval system