KEGG   PATHWAY: pfa03013
Entry
pfa03013                    Pathway                                
Name
Nucleocytoplasmic transport - Plasmodium falciparum 3D7
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
pfa03013  Nucleocytoplasmic transport
pfa03013

Other DBs
GO: 0050658
Organism
Plasmodium falciparum 3D7 [GN:pfa]
Gene
PF3D7_1459000  ATP-dependent RNA helicase DBP5 [KO:K18655] [EC:5.6.2.7]
PF3D7_0915100  SUMO-conjugating enzyme UBC9 [KO:K10577]
PF3D7_1230700  protein transport protein SEC13 [KO:K14004]
PF3D7_0405600  TMEM33 domain-containing protein, putative [KO:K20724]
PF3D7_0812400  karyopherin alpha [KO:K15042]
PF3D7_0815200  importin subunit beta, putative [KO:K14293]
PF3D7_0627700  transportin [KO:K18752]
PF3D7_0524000  karyopherin beta [KO:K20222]
PF3D7_0706000  importin-7, putative [KO:K20223]
PF3D7_0302900  exportin-1, putative [KO:K14290]
PF3D7_0932800  importin alpha re-exporter, putative [KO:K18423]
PF3D7_1315900  exportin-T, putative [KO:K14288]
PF3D7_0910100  exportin-7, putative [KO:K18460]
PF3D7_1117700  GTP-binding nuclear protein RAN/TC4 [KO:K07936]
PF3D7_1357000  elongation factor 1-alpha [KO:K03231]
PF3D7_1357100  elongation factor 1-alpha [KO:K03231]
PF3D7_0415500  nuclear cap-binding protein subunit 2, putative [KO:K12883]
PF3D7_0729300  60S ribosomal export protein NMD3, putative [KO:K07562]
PF3D7_1406000  RNA-binding protein 8A, putative [KO:K12876]
PF3D7_0725200  mago nashi protein homologue, putative [KO:K12877]
PF3D7_0422700  eukaryotic initiation factor 4A-III, putative [KO:K13025] [EC:5.6.2.7]
PF3D7_0615700  RNA and export factor binding protein, putative [KO:K12881]
PF3D7_1005500  regulator of nonsense transcripts 1, putative [KO:K14326] [EC:5.6.2.5 5.6.2.3]
PF3D7_0925800  armadillo repeat protein, putative [KO:K14327]
PF3D7_0209800  ATP-dependent RNA helicase UAP56 [KO:K12812] [EC:5.6.2.7]
PF3D7_1209000  mago-binding protein, putative [KO:K14294]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
pfa03015  mRNA surveillance pathway
KO pathway
ko03013   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG GENES (26)   
All databases (27)   

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