KEGG   PATHWAY: pfa03420
Entry
pfa03420                    Pathway                                
Name
Nucleotide excision repair - Plasmodium falciparum 3D7
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
pfa03420  Nucleotide excision repair
pfa03420

Other DBs
GO: 0006289
Organism
Plasmodium falciparum 3D7 [GN:pfa]
Gene
PF3D7_0514100  ATP-dependent DNA helicase UvrD [KO:K03657] [EC:5.6.2.4]
PF3D7_0319100  E3 ubiquitin-protein ligase RBX1, putative [KO:K03868] [EC:2.3.2.32]
PF3D7_1011700  DNA repair protein RAD23, putative [KO:K10839]
PF3D7_0318200  DNA-directed RNA polymerase II subunit RPB1 [KO:K03006] [EC:2.7.7.6]
PF3D7_0215700  DNA-directed RNA polymerase II subunit RPB2, putative [KO:K03010] [EC:2.7.7.6]
PF3D7_0923000  DNA-directed RNA polymerase II subunit RPB3, putative [KO:K03011]
PF3D7_0205500  DNA-directed RNA polymerase II 16 kDa subunit, putative [KO:K03012]
PF3D7_1364800  DNA-directed RNA polymerases I, II, and III subunit RPABC1, putative [KO:K03013]
PF3D7_0303300  DNA-directed RNA polymerases I, II, and III subunit RPABC2, putative [KO:K03014]
PF3D7_1027400  DNA-directed RNA polymerase II subunit RPB7, putative [KO:K03015]
PF3D7_1213700  DNA-directed RNA polymerases I, II, and III subunit RPABC3, putative [KO:K03016]
PF3D7_0110400  DNA-directed RNA polymerase II subunit RPB9, putative [KO:K03017]
PF3D7_0708100  DNA-directed RNA polymerases I, II, and III subunit RPABC5, putative [KO:K03007]
PF3D7_1342700  DNA-directed RNA polymerases I, II, and III subunit RPABC4, putative [KO:K03009]
PF3D7_1304900  DNA-directed RNA polymerase II subunit RPB11, putative [KO:K03008]
PF3D7_1014400  MO15-related protein kinase [KO:K02202] [EC:2.7.11.22 2.7.11.23]
PF3D7_0512300  CDK-activating kinase assembly factor MAT1 [KO:K10842]
PF3D7_1463700  cyclin 1 [KO:K06634]
PF3D7_1037600  TFIIH basal transcription factor complex helicase XPB subunit, putative [KO:K10843] [EC:5.6.2.4]
PF3D7_0934100  TFIIH basal transcription factor complex helicase XPD subunit [KO:K10844] [EC:5.6.2.3]
PF3D7_1441900  RNA polymerase II transcription factor B subunit 5, putative [KO:K10845]
PF3D7_1314900  general transcription factor IIH subunit 2 [KO:K03142]
PF3D7_1353500  RNA polymerase II transcription factor B subunit 4, putative [KO:K03143]
PF3D7_1244200  RNA polymerase II transcription factor B subunit 2, putative [KO:K03144]
PF3D7_0206000  DNA repair protein RAD2, putative [KO:K10846]
PF3D7_0409600  replication protein A1, large subunit [KO:K07466]
PF3D7_1442100  replication factor A protein 3, putative [KO:K10740]
PF3D7_1368800  DNA repair endonuclease XPF, putative [KO:K10848] [EC:3.1.-.-]
PF3D7_0203300  ERCC1 nucleotide excision repair protein, putative [KO:K10849]
PF3D7_1017000  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
PF3D7_0308000  DNA polymerase delta small subunit, putative [KO:K02328]
PF3D7_0630300  DNA polymerase epsilon catalytic subunit A, putative [KO:K02324] [EC:2.7.7.7]
PF3D7_1234300  DNA polymerase epsilon subunit B, putative [KO:K02325] [EC:2.7.7.7]
PF3D7_1361900  proliferating cell nuclear antigen 1 [KO:K04802]
PF3D7_1226600  proliferating cell nuclear antigen 2 [KO:K04802]
PF3D7_0219600  replication factor C subunit 1, putative [KO:K10754]
PF3D7_0218000  replication factor C subunit 2, putative [KO:K10755]
PF3D7_1241700  replication factor C subunit 4, putative [KO:K10755]
PF3D7_1463200  replication factor C subunit 3, putative [KO:K10756]
PF3D7_1111100  replication factor C subunit 5, putative [KO:K10756]
PF3D7_1304100  DNA ligase I [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
pfa03020  RNA polymerase
pfa04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (41)   
   KEGG GENES (41)   
All databases (42)   

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